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  4. Recombinant Mouse EF-hand domain-containing family member A1 (Efha1)

Recombinant Mouse EF-hand domain-containing family member A1 (Efha1)

  • 货号：
    CSB-YP804021MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP804021MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP804021MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP804021MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP804021MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Micu2
  • Uniprot No.：
  • 别名：
    Micu2; Efha1; Calcium uptake protein 2; mitochondrial; EF-hand domain-containing family member A1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-432
  • 氨基酸序列
    MAAAAGRSAW LAAWGGRLRR GLAAGRRAVP TRGPLAAAVA GVALAGAGAA WHHGRVKAAA REGSRTVSAQ KNYLGPIEKL SLRKQRFMQF SSLEHDGEYY MTPRDFLFSV MFEQVERKTL VKKLAKKDIE DVLSGIQTAR CGSTFFRDLG DKGVISYTEY LFLLTILTKP HSGFHVAFKM LDVDGNEMIE RKEFVKLQKI ISKQDGFKTV KTNETEYQDP TVKEPGVNTT LQVRFFGKRG EKKLHYKEFR RFMENLQTEV QEMEFLQFSK GLNFMRKEDF AEWLLFFTNT ENKDIYWRNV REKLSVGESI SLDEFKSFCH FTTHLEDFAI AMQMFSLAHR PVRLAEFKRA VKVATGQELS DNLLDTVFKI FDLDGDECLS HGEFLGVLKN RMHRGLWVSQ QQSVQEYWKC VKKESIKGVK EAWRQQAGKG PF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting Ca(2+), avoiding energy dissipation and cell-death triggering.
  • 基因功能参考文献：
    1. Micu2 role in regulating angiotensin II-mediated hypertensive responses that are critical in protecting the abdominal aorta from injury. PMID: 29073106
    2. a possible role for tissue-specific stoichiometry between the Ca(2+)-sensing regulators (MICUs) and pore unit (MCU) of the uniporter, was investigated. PMID: 28273446
  • 亚细胞定位：
    Mitochondrion intermembrane space.
  • 蛋白家族：
    MICU1 family, MICU2 subfamily
  • 组织特异性：
    Predominantly expressed in stomach, intestine, skeletal muscle, kidney, heart, testis, prostate and uterus.
  • 数据库链接：

    KEGG: mmu:68514

    STRING: 10090.ENSMUSP00000022543

    UniGene: Mm.26834