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  4. Recombinant Mouse ELL-associated factor 2 (Eaf2)

Recombinant Mouse ELL-associated factor 2 (Eaf2)

  • 中文名称：
    小鼠Eaf2重组蛋白
  • 货号：
    CSB-YP838711MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Eaf2重组蛋白
  • 货号：
    CSB-EP838711MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Eaf2重组蛋白
  • 货号：
    CSB-EP838711MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Eaf2重组蛋白
  • 货号：
    CSB-BP838711MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Eaf2重组蛋白
  • 货号：
    CSB-MP838711MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Eaf2
  • Uniprot No.：
  • 别名：
    Eaf2; Festa; TraitsELL-associated factor 2; Ehrlich S-II transcriptional activator factor; Testosterone-regulated apoptosis inducer and tumor suppressor protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-262
  • 氨基酸序列
    MSGPAGLAYL DRRERVLKLG ESFEKQPRCA FHTVRYDFKP ASIDTSCEGN LEVGKGEQVT ITLPNIEGST PPVTVFKGSK RPYLKECILI INHDTGECRL EKLSSNITVK KTRVEGSSRI QYRLEQQQQQ MWNLPRTSNL VQHSPSEEKM SPTSLMDDIE RELKAEASLM DQMSSCDSSS DSKSSSSSSS EDSSSDSEDD DQFSPLGPRK YSSEHPSMSA GPQYRTSEAD ATCHRLQDHS TLLMSTLRSD LQLSESESDS ED
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Acts as a transcriptional transactivator of TCEA1 elongation activity.
  • 基因功能参考文献：
    1. Data show that p53 and EAF2 knockout mice developed prostate cancer. PMID: 29029019
    2. The results showed that Eaf2 knockout can reduce UV-induced apoptosis in crystalline lenses and mitigate the formation of cataracts. PMID: 26328919
    3. These results demonstrate that EAF2-mediated apoptosis in GC B cells limits excessive humoral immune responses and is important for maintaining self-tolerance. PMID: 26935903
    4. these findings together demonstrated synergistic functional interactions and clinical relevance of concurrent EAF2 and Pten downregulation in prostate carcinogenesis. PMID: 23708662
    5. Mice deficient in EAF2 had an increased recovery rate and a decreased overall response to the effects of androgen deprivation. PMID: 24260246
    6. cooperation of VHL and EAF2 may be critical for angiogenic regulation of the liver and prostate, and concurrent loss of these two tumor suppressors may result in a pro-angiogenic phenotype. PMID: 21638067
    7. Inhibition of 5alpha-reductase during prostatic tumor regrowth enhances the expression of U19/Eaf2, an androgen-regulated tumor suppressor. PMID: 20564326
    8. Data show that the expression of TSP-1 is down-regulated in the prostate and liver of U19/EAF2 knockout mouse. PMID: 19826414
    9. Expression of Eaf2 is developmentally regulated. PMID: 14517999
    10. Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia PMID: 17873910
    11. Transcriptional activation mediated by FESTA/EAF2, a transcription factor that interacts with S-II, was decreased in RNA polymerase II deficient embryonic stem cells. PMID: 17892859
    12. Following UV irradiation, Eaf2 is relocalized to the nucleolus, suggesting a possible functional involvement of Eaf2 in DNA damage response. PMID: 18803460

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  • 亚细胞定位：
    Nucleus speckle.
  • 蛋白家族：
    EAF family
  • 组织特异性：
    Isoform 1 is expressed in ovary, uterus, mammary glands, brain, spleen, liver, lung, thymus, kidney, skeletal muscle, skin and testis. Isoform 2 is expressed in kidney.
  • 数据库链接：

    KEGG: mmu:106389

    STRING: 10090.ENSMUSP00000110477

    UniGene: Mm.432078