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  4. Recombinant Mouse ERO1-like protein beta (Ero1lb)

Recombinant Mouse ERO1-like protein beta (Ero1lb)

  • 中文名称：
    小鼠Ero1b重组蛋白
  • 货号：
    CSB-YP837127MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ero1b重组蛋白
  • 货号：
    CSB-EP837127MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ero1b重组蛋白
  • 货号：
    CSB-EP837127MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ero1b重组蛋白
  • 货号：
    CSB-BP837127MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ero1b重组蛋白
  • 货号：
    CSB-MP837127MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ero1b; Ero1lbERO1-like protein beta; ERO1-L-beta; EC 1.8.4.-; Endoplasmic reticulum oxidoreductase beta; Endoplasmic reticulum oxidoreductin-1-like protein B; Oxidoreductin-1-L-beta
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    34-467
  • 氨基酸序列
    QVTGVLD DCLCDIDSID KFNTYKIFPK IKKLQERDYF RYYKVNLKRP CPFWAEDGHC SIKDCHVEPC PESKIPVGIK AGRSNKYSQA ANSTKELDDC EQANKLGAIN STLSNESKEA FIDWARYDDS QDHFCELDDE RSPAAQYVDL LLNPERYTGY KGSSAWRVWN SIYEENCFKP RSVYRPLNPL APSRGEDDGE SFYTWLEGLC LEKRVFYKLI SGLHASINLH LCANYLLEET WGKPSWGPNI KEFRRRFDPV ETKGEGPRRL KNLYFLYLIE LRALSKVAPY FERSIVDLYT GNVEDDADTK TLLLSIFQDT KSFPMHFDEK SMFAGDKKGA KSLKEEFRLH FKNISRIMDC VGCDKCRLWG KLQTQGLGTA LKILFSEKEI QNLPENSPSK GFQLTRQEIV ALLNAFGRLS TSIRELQNFK ALLQHRR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2, PDIA3, PDIA4, PDIA6 and NXNDC12. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Involved in oxidative proinsulin folding in pancreatic cells, hence required for glucose homeostasis in vivo.
  • 基因功能参考文献：
    1. in diabetic model mice, ERO1beta expression is paradoxically decreased in beta cells despite the indications of increased ER stress PMID: 24469402
    2. Several lines of evidence suggest that ERO1lbeta is involved in maintaining insulin content of pancreatic beta cells and in regulating beta cell survival during ER oxidative stress. PMID: 21540283
    3. An unexpectedly selective function for ERO1-beta in oxidative protein folding in insulin-producing cells that is required for glucose homeostasis in vivo. PMID: 20308425
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
  • 蛋白家族：
    EROs family
  • 组织特异性：
    Predominantly expressed in stomach and pancreas (mostly in the islets of Langerhans) (at protein level).
  • 数据库链接：

    KEGG: mmu:67475

    STRING: 10090.ENSMUSP00000071864

    UniGene: Mm.358706