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  4. Recombinant Mouse ETS-related transcription factor Elf-5 (Elf5)

Recombinant Mouse ETS-related transcription factor Elf-5 (Elf5)

  • 中文名称：
    小鼠Elf5重组蛋白
  • 货号：
    CSB-YP851830MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Elf5重组蛋白
  • 货号：
    CSB-EP851830MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Elf5重组蛋白
  • 货号：
    CSB-EP851830MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Elf5重组蛋白
  • 货号：
    CSB-BP851830MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Elf5重组蛋白
  • 货号：
    CSB-MP851830MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Elf5
  • Uniprot No.：
  • 别名：
    Elf5ETS-related transcription factor Elf-5; E74-like factor 5
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-253
  • 氨基酸序列
    MLDSVTHSTF LPNASFCDPL MPWTDLFSNE DYYPAFEHQT ACDSYWTSVH PEYWTKRHVW EWLQFCCDQY KLDANCISFC HFNISGLQLC SMTQEEFIEA AGICGEYLYF ILQNIRSQGY SFFNDAEETK TGIKDYADSS CLKTSGIKSQ DCHSRTSLQS SHLWEFVRDL LLSPEENCGI LEWEDREQGI FRVVKSEALA KMWGQRKKND RMTYEKLSRA LRYYYKTGIL ERVDRRLVYK FGKNAHGWQE EKL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. Binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates the TK promoter.
  • 基因功能参考文献：
    1. Downregulation of ELF5 increases the expression of AR-response genes and the progression of prostate cancer. ELF5 interaction with AR is androgen dependent. PMID: 28287091
    2. Mechanistically, RL negatively regulates Stat5 phosphorylation and Elf5 expression at the onset of lactogenesis. Continuous RL exposure leads to the expansion of basal and bipotent cells in WT and MMTV-RANK acini. Overall, we demonstrate that enhanced Rank signaling impairs secretory differentiation during pregnancy by inhibition of the prolactin/p-Stat5 pathway. PMID: 26695351
    3. Elf5 at the center of a stoichiometry-sensitive transcriptional network, where it acts as a molecular switch governing the balance between TSC proliferation and differentiation PMID: 26584622
    4. Elf5 and Ets2 maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner PMID: 25446535
    5. Elf5 counteracts precocious trophoblast differentiation by maintaining Sox2 and 3 and inhibiting Hand1 expression. PMID: 24859262
    6. Blockade of RankL action prevented progesterone-induced side branching and the expansion of Elf5(+) mature luminal cells. PMID: 23462470
    7. Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. PMID: 23086238
    8. Studies suggest that Elf5 loss leads to hyperactivation of the Notch signaling pathway, which might constitute in part, the underlying molecular mechanism for the altered cell lineage decisions in Elf5-null mammary epithelial cells. PMID: 22523003
    9. Elf5 promoter methylation is regulated during mammary differentiation in vivo. PMID: 21823211
    10. identify novel transcriptional targets of Elf5 and show that Muc4 is a direct target of Elf5, further elucidating the mechanisms through which Elf5 regulates proliferation and differentiation in the mammary gland PMID: 20949099
    11. Elf5 is essential for developmental processes in the embryo and in the mammary gland during pregnancy PMID: 15650748
    12. demonstrated for the first time that Elf5 protein is localised to epithelium of exocrine glands including the kidney, mammary gland, stomach and the submandibular salivary gland PMID: 15655699
    13. Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning. PMID: 15829518
    14. KRF is a novel transcription factor that is restricted to nuclear extracts isolated from keratinocytes and that binds to unique DNA sequences, which do not resemble any known consensus binding motif for transcription factors.[KRF] PMID: 16229011
    15. Socs2 and Elf5 are key members of the set of prolactin-regulated genes that mediate prolactin-driven mammary development. PMID: 16469767
    16. Elf5 is an FGF-sensitive transcription factor in the lung with a dynamic pattern of expression, and FGF regulation of Elf5 by means of FGFR2b occurs through the PI3-Kinase/Akt pathway. PMID: 17394208
    17. analysis reveals previously undiscovered expression site for Elf5 in the differentiated cells of the inner root sheath of hair follicle PMID: 17938949
    18. Elf5 specifies the differentiation of CD61+ progenitors to establish the secretory alveolar lineage during pregnancy, providing a link between prolactin, transcriptional events, and alveolar development. PMID: 18316476
    19. These results suggest that precise levels of ELF5 regulate the specification and differentiation of epithelial cells in the lung. PMID: 18544451
    20. Epigenetic restriction of embryonic cell lineage by methylation of Elf5 is reported. PMID: 18836439
    21. propose a model for Elf5-mediated alveolar development, in which Elf5 regulates the expression of key mediators of the PrlR/Jak2/Stat5 signaling pathway PMID: 19269284

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ETS family
  • 组织特异性：
    Expressed in lung, kidney, stomach, brain, ovaries, tongue, bladder and mammary glands.
  • 数据库链接：

    KEGG: mmu:13711

    STRING: 10090.ENSMUSP00000028609

    UniGene: Mm.20888