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  4. Recombinant Mouse Early growth response protein 1 (Egr1), partial

Recombinant Mouse Early growth response protein 1 (Egr1), partial

  • 货号：
    CSB-YP007484MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP007484MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP007484MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP007484MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP007484MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Egr1; Egr-1; Krox-24Early growth response protein 1; EGR-1; Nerve growth factor-induced protein A; NGFI-A; Transcription factor Zif268; Zinc finger protein Krox-24
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 表达区域：
    333-421aa
  • 氨基酸序列
    ERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDICGRKFARSDERKRHTKIHLRQKD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary. Regulates the amplitude of the expression rhythms of clock genes: ARNTL/BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene ARNTL/BMAL1 in the suprachiasmatic nucleus (SCN).
  • 基因功能参考文献：
    1. Tet1 overexpression affected adult neurogenesis with oligodendrocyte differentiation in the hippocampal dentate gyrus of Tet1-TG mice. In addition, Tet1 overexpression induced the elevated expression of immediate early genes, such as Egr1, c-fos, Arc, and Bdnf, followed by the activation of intracellular calcium signals in prefrontal and hippocampal neurons. PMID: 28899881
    2. Our study provides strong evidence that Egr1 is a transcriptional activator of NOX4 in oxidative stress of DKD. Egr1 contributes to diabetic kidney disease by enhancing EMT, in part by targeting NOX4. PMID: 29854821
    3. these results revealed that EGR-1 appears to facilitate VACV replication in starved fibroblasts by affecting viral particles infectivity. PMID: 29561772
    4. EGR1-deficient mice displayed a reduced locomotor activity and altered temperature regulation. EGR1-deficient mice displayed disrupted activity rhythm with no measurable endogenous period length. The daily rhythm of BMAL1 mRNA was completely abolished in the EGR1-deficient mice. PMID: 29138967
    5. Egr1(-/-) mice on the C57BL/6 background have normal eyelid development, but back-crossing to BALB/c background for four or five generations resulted in defective eyelid development by day E15.5. PMID: 28778995
    6. Data (including date from studies in knockout mice) suggest that EGR1 is essential in response of airway epithelium to urban pollution/particulate matter (PM); particulate matter induces rapid up-regulation of expression of EGR1 in human bronchial epithelial cells and of Egr1 in mouse lungs. Egr1 knockout mice exhibit significantly reduced airway inflammation and mucus hyper-production in response to PM exposure in vivo. PMID: 29787794
    7. Egr-1 deficiency attenuates NF-kappaB and TGFbeta-mediated renal inflammation/fibrosis. PMID: 26960759
    8. miR-301b promotes the proliferation, migration, and aggressiveness of human bladder cancer cells by inhibiting the expression of EGR1 PMID: 28521108
    9. Egr-1 upregulation is characteristic of the cardiovascular disease pathogenesis. (Review) PMID: 27251707
    10. Low EGR1 expression is associated with cardiac ischemia and systolic dysfunction. PMID: 28771625
    11. Herein, we report that silencing of Egr-1 in the hippocampus by shRNA reduces tau phosphorylation, lowers amyloid-beta (Abeta) pathology, and improves cognition in the 3xTg-Alzheimer disease mouse model. PMID: 28641077
    12. Egr-1 is a novel regulator of drebrin expression, which is linked to changes in dendritic spine density PMID: 28369888
    13. In the present study, we have investigated the contribution of element C to Krox20 expression, as it was the only characterized initiator element with an activity in r3. Using a conditional knock-out mutation of element C, we show that, unexpectedly, this element is not necessary for Krox20 initial expression in r3. PMID: 28749941
    14. Egr1 expression is sensitive to mechanical signals in tendon cells. PMID: 27820865
    15. age-related up-regulation of EGR1 promotes granulosa cell apoptosis in follicle atresia during ovarian aging. PMID: 27436181
    16. data indicate that Egr-1 promotes Abeta synthesis via transcriptional activation of BACE-1 and suggest that Egr-1 plays role in activation of BACE-1 and acceleration of Abeta synthesis in AD brain. PMID: 27576688
    17. EGR1, an early growth response factor, is a critical transcription factor that regulates the hepatic clock circuit. PMID: 26471974
    18. EGR1(-/-) mouse embryonic fibroblasts demonstrated lower susceptibility to Venezuelan equine encephalitis virus-induced cell death than isogenic wild-type fibroblasts, indicating that EGR1 modulates proapoptotic pathways following virus infection. PMID: 26792742
    19. The levels of B23 expression are directly regulated by EGR1. PMID: 26577150
    20. our data demonstrate that the effect of FGF23 on Pi homeostasis is mediated, at least in part, by activation of egr-1. PMID: 26588476
    21. associated with this behavior, that is, an increase in the expression of the immediate early gene Early Growth Response protein 1 (EGR1, Zif268) PMID: 26221832
    22. ERG1 overexpression led to the development of highly aggressive B-cell malignancies. PMID: 25906746
    23. EGR-1-induced GGPPS plays a vital role in the liver regeneration through the RAS/MAPK signaling. PMID: 25882493
    24. Egr1 plays an important role in ischemia-reperfusion injury in lung transplants by regulating polymorphonuclear neutrophil infiltration. PMID: 26079744
    25. Deficiency of Egr1 in the haematopoietic compartment of mice completely abolished the incidence of CaCl2-induced aneurysm formation. PMID: 26113112
    26. present results support the involvement of nuclear factor kappa B activity-dependent Zif268 expression in the hippocampus during recognition memory consolidation. PMID: 25576790
    27. This study demonstrates that Ang II can induce the expression of Egr-1 via AT1R/JNK and ERK signaling pathways. PMID: 25591955
    28. 4E-BP1/2-null cells express less ATGL and accumulate more fat than control cells, while knock down of Egr1 in 4E-BP1/2-null cells increases ATGL expression and decreases fat storage. PMID: 25814662
    29. This study demonstrated that Early growth response 1 (Egr-1) directly regulates GABAA receptor alpha2, alpha4, and theta; subunits in the hippocampus. PMID: 25708312
    30. study suggests that early growth response 1(Egr1) decreases /signal transducer and activator of transcription 3(STAT3) expression via microRNA-106a in ovariectomized mice with cognitive impairment PMID: 24686449
    31. Activation of the Egr1 gene involves sliding and/or eviction of nucleosomes around the transcription start site and nucleosome-specific, time-dependent changes in histone modifications. PMID: 25378406
    32. Egr-1 acts as immediate glucose biological sensor in cMSCs after a short period of stimuli, likely inducing epigenetic modifications. PMID: 24967343
    33. These findings suggest that dysfunctions of Egr-1 and neuro-signaling systems are involved in social isolation-induced deficits of fear memory consolidation in mice. PMID: 24647971
    34. These results confirm the presence of EGR1 in the nucleolus and point to a role for EGR1 in the control of nucleolar metabolism. PMID: 24787739
    35. study presents for the first time that estrogen regulates Egr1 expression through LIF-STAT3 signaling pathway in mouse uterus, and Egr1 functions as a critical mediator of stromal cell decidualization by regulating Wnt4 PMID: 25012664
    36. EGR1 gene knockout in mice impairs extinction of learned contextual fear memory . PMID: 24552706
    37. Zif268 participates in the processes underlying performance and motivation to execute food-conditioned instrumental task. PMID: 24465372
    38. EGR-1 plays a role in the interplay of acetylcholine and serotonin in the regulation of neurite extension during development PMID: 24158140
    39. The results of this study suggest that EGR1 regulates the expression of genes involved in CME, vesicular transport and synaptic transmission that may be critical for AD pathogenesis. PMID: 24269917
    40. Zif268/Egr1 gain of function facilitates hippocampal synaptic plasticity and long-term spatial recognition memory. PMID: 24298160
    41. Egr-1 may promote endothelial cell proliferation and result in vein graft restenosis by upregulating the expression of ICAM-1. PMID: 24386503
    42. The amount of Ncx1 protein was increased in Egr-1(-/-) hearts. PMID: 24289086
    43. Cav3.2 is induced early by Egr1 during cardiac hypertrophy and Cav3.2 is an important mediator of Egr1 in regulating cardiac hypertrophy. PMID: 23929524
    44. loss of Tp53 activity in cooperation with Egr1 and Apc haploinsufficiency creates an environment that is permissive for malignant transformation and the development of AML. PMID: 24381225
    45. Genetic and pharmacological characterization of the role of ERK1/2 and Zif268 in contextual fear memory processing. PMID: 23977192
    46. These studies demonstrated sustained activation of Egr-1 with subsequent induction of its downstream target genes in diabetic mouse aortas and in high glucose-treated primary murine aortic endothelial cells expressing human aldose reductase. PMID: 24186862
    47. COUP-TFI regulates tyrosine hydroxylase expression in olfactory bulb cells through an activity-dependent mechanism involving ZIF268 induction PMID: 24227652
    48. in vivo biochemical or genetic inhibition of NFATc2 activity in megakaryocyte diminishes platelet CD40L implicates the NFATc2/EGR-1 axis as a key regulatory pathway of inflammatory and immunomodulatory activity in platelets PMID: 24106272
    49. s conclude that decreased Egr1 expression is a very early transcriptional effect of YopM and speculate that a pathway may exist from RSK1 through Egr1. PMID: 23248776
    50. Feeding animals a high-fat diet increases the activity of mTORC1 and the expression of Egr1 while decreasing ATGL levels in epididymal fat. PMID: 23858058

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    EGR C2H2-type zinc-finger protein family
  • 组织特异性：
    Detected in lung vasculature and in mononuclear phagocytes. Detected in liver (at protein level). Detected in lung vasculature and in mononuclear phagocytes. Expressed in the liver in a circadian manner.
  • 数据库链接：

    KEGG: mmu:13653

    STRING: 10090.ENSMUSP00000069616

    UniGene: Mm.181959