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  4. Recombinant Mouse Ectonucleoside triphosphate diphosphohydrolase 1 (Entpd1), partial

Recombinant Mouse Ectonucleoside triphosphate diphosphohydrolase 1 (Entpd1), partial

  • 中文名称：
    小鼠Entpd1重组蛋白
  • 货号：
    CSB-YP007690MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Entpd1重组蛋白
  • 货号：
    CSB-EP007690MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Entpd1重组蛋白
  • 货号：
    CSB-EP007690MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Entpd1重组蛋白
  • 货号：
    CSB-BP007690MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Entpd1重组蛋白
  • 货号：
    CSB-MP007690MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Entpd1; Cd39Ectonucleoside triphosphate diphosphohydrolase 1; NTPDase 1; EC 3.6.1.5; Ecto-ATP diphosphohydrolase 1; Ecto-ATPDase 1; Ecto-ATPase 1; Ecto-apyrase; Lymphoid cell activation antigen; CD antigen CD39
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
  • 基因功能参考文献：
    1. CD39 is highly expressed by CD8+ tumor-infiltrating T lymphocytes. PMID: 29066514
    2. Furthermore, our results suggest a crucial role for the enzyme CD39 in limiting P2X7 receptor proinflammatory responses since CD39(-/-) septic mice exhibited higher levels of IL-1beta in the brain. PMID: 27730511
    3. CD39 expression in macrophages limits P2X7-mediated pro-inflammatory responses, scavenging extracellular ATP and ultimately generating adenosine. CD39 genetic deletion exacerbates sepsis-induced experimental liver injury. PMID: 28554875
    4. complete deletion of Cd39 paradoxically attenuates development of atherosclerosis in hyperlipidemic mice PMID: 28487312
    5. Deletion of CD39 and CD73 or both caused an inhibition of the microglia ramified phenotype in the brain with a reduction in the length of processes, branching frequency and number of intersections with Sholl spheres. In vitro, unlike wild-type microglia, cd39-/- and cd73-/- microglial cells were less complex and did not respond to ATP with the transformation into a more ramified phenotype. PMID: 28376099
    6. CD39 expression by Th17 cells allows the depletion of ATP and is crucial for IL-10 production and survival during the resolution of intestinal inflammation. PMID: 27322617
    7. Cardiac-specific expression of CD39 reduces myocardial dysfunction and infarct size following ischemia-reperfusion injury PMID: 27756600
    8. Data indicate that adenosine and CGS21680 upregulate CD39 and CD73 via E2F-1 and CREB. PMID: 27430240
    9. Acute cigarette smoke exposure induced CD39 upregulation in murine lungs and BALF cells. CD39 inhibition and deficiency led to augmented lung inflammation. PMID: 26541524
    10. CD39 role in neuroinflammation: CD39 defines regulatory phenotypes in CD4-positive T cells. PMID: 25043484
    11. data suggest that CD39 expression in liver allografts modulates tissue injury PMID: 25661084
    12. these data establish CD39 as a regionalized regulator of atherogenesis that is driven by shear stress. PMID: 26121751
    13. The Na-K-2Cl cotransporter was downregulated by high-sodium diet in wild-type mice, but it increased in transgenic mice overexpressing human CD39 PMID: 25877509
    14. Activated regulatory T-cells attenuate myocardial ischaemia/reperfusion injury through a CD39-dependent mechanism. PMID: 25558978
    15. by regulating ATP availability at the cardiac mast cell surface surface, CD39 modulates local renin release and thus, renin-angiotensin system activation, ultimately exerting a cardioprotective effect PMID: 25318477
    16. Knockout of CD39 increased mortality in polymicrobial sepsis induced by cecal ligation and puncture. CD39 decreased inflammation, organ damage, immune cell apoptosis, and bacterial load. CD39 expression in myeloid cells decreased inflammation in sepsis. PMID: 25318479
    17. In mast cells CD39 sets an activation threshold for the P2X7-dependent inflammatory cell death and concomitant IL-1beta release. PMID: 25184735
    18. NTPDase1 controls male fertility via the regulation of P2X1 activation. PMID: 25160621
    19. that extracellular adenosine, generated in tandem by ecto-enzymes CD39 and CD73, promotes dermal fibrogenesis. PMID: 24266925
    20. marker of regulatory gammadelta T cells PMID: 23870672
    21. Taken together, these data show that CD39 plays a prominent role in controlling ATP levels and thereby microglial phagocytosis. PMID: 23208703
    22. Data indicate that extracellular ATP (eATP) is rapidly hydrolyzed by the macrophage ectoenzyme CD39. PMID: 23908469
    23. conclude that gestational hypertension can be induced in mice following transfer of maternally derived Th1-polarized cells and that overexpression of CD39 is protective PMID: 23600369
    24. Cd39-deficient DCs exhibit limited capacity to induce Th2 immunity in a DC-driven model of AAI in vivo. PMID: 23452076
    25. CD39KO mice developed diabetes more rapidly and with higher frequency than WT mice. In contrast, CD39TG mice were protected. CD39 overexpression conferred protection through the activation of adenosine 2A receptor and adenosine 2B receptor. PMID: 23364452
    26. Deletion of Cd39 and resulting changes in disordered purinergic signaling perturb hepatocellular metabolic/proliferative responses, paradoxically resulting in malignant transformation. PMID: 22859060
    27. identified hitherto unrecognized soluble forms of AK1 and NTPDase1/CD39 that contribute in the active cycling between the principal platelet-recruiting agent ADP and other circulating nucleotides PMID: 22637533
    28. CD39 apyrase-expressing CD4+ T cells stimulated by Salmonella vector-expressing E coli colonization factor antigen I (CFA/I) are composed of TGF-beta-producing Foxp3- CD39+CD4+ T cells and support the stimulation of IL-10-producing Foxp3+ CD39+CD4+ T cells. PMID: 21967895
    29. Study suggests that extracellular ATP formed during I/R is preferentially degraded by CD39 present on myeloid cells, while the formation of immunosuppressive adenosine is mainly catalysed by CD73 present on granulocytes and lymphoid cells. PMID: 22514659
    30. Stat3 supported whereas Gfi-1 repressed CD39 and CD73 expression by binding to their promoters. PMID: 22406269
    31. Data indicate that untreated murine adenosine deaminase ADA(-/-) Tregs show alterations in the plasma membrane CD39/CD73. ectonucleotidase machinery and limited suppressive activity via extracellular adenosine. PMID: 22184407
    32. CD39/CD73 coexpression is a novel important component of the immunoregulatory functions of murine Multipotent mesenchymal stromal cells. PMID: 21176405
    33. Impaired adaptive cellular immune reactivity in the CD39-null environment appears protective in hapten-mediated Th1-type colitis. PMID: 20936356
    34. CD39 expression on CD4+Foxp3+ Tregs inhibits natural killer cell activity and is permissive for hepatic metastatic growth. PMID: 20546740
    35. CD39 is the dominant ectonucleotidase in peritoneal macrophages. It regulates P2X7-associated IL-1beta release independently of, and prior to, cytokine maturation by caspase-1. It inhibits IL-1beta release in the air pouch inflammatory model. PMID: 20201036
    36. CD39 deficiency and changes in P2 receptor activation abrogate secretion of interferon gamma by NK cells in response to inflammatory mediators, thereby limiting tissue damage mediated by these innate immune cells during ischemia reperfusion injury PMID: 20146261
    37. Our data suggest a Sp1-dependent regulatory pathway for CD39 during hepatic ischemic preconditioning. PMID: 20207994
    38. NTPDase1 is the major enzyme regulating nucleotide metabolism at the surface of VSMCs and thus contributes to the local regulation of vascular tone by nucleotides. PMID: 19640930
    39. catalytic properties and vascular topography have implications for thromboregulation PMID: 11929769
    40. Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain. PMID: 11956240
    41. CD39 activity modulates platelet activation and vascular leak during intestinal ischemia reperfusion injury in vivo PMID: 14983235
    42. NTPDases may modulate regulatory effects of ATP and degradation products within the vasculature and other sites and thereby potentially influence physiological as well as multiple pathological events in the kidney. PMID: 15632415
    43. ENTPD1 is a vascular protective factor in diabetic nephropathy that modulates glomerular inflammation and thromboregulation. PMID: 17473221
    44. CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation. PMID: 17502665
    45. Pulmonary CD39 and CD73 are induced by mechanical ventilation. PMID: 17548651
    46. by reducing presynaptic facilitatory effects of neurotransmitter ATP, CD39 attenuates norepinephrine release and its dysfunctional consequences. PMID: 17565006
    47. Theses data indicate novel links between CD39/ENTPD1, extracellular nucleotide-mediated signaling, and vascular endothelial cell integrin function that impact on angiogenesis and tumor growth. PMID: 17823293
    48. robust and selective induction of E-NTPDase 1 (CD39) transcript and protein after myocardial ischemia preconditioning PMID: 17909107
    49. The ectonucleotidase cd39/ENTPDase1 modulates purinergic-mediated microglial migration. PMID: 18098126
    50. Knockout mice demonstrate a reduction in tubuloglomerular feedback (TGF) responses, as determined by proximal tubular stop flow pressure measurements. PMID: 18256308

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    GDA1/CD39 NTPase family
  • 数据库链接：

    KEGG: mmu:12495

    STRING: 10090.ENSMUSP00000107850

    UniGene: Mm.2824