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  4. Recombinant Mouse Endonuclease 8-like 2 (Neil2)

Recombinant Mouse Endonuclease 8-like 2 (Neil2)

  • 货号：
    CSB-YP744172MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP744172MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP744172MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP744172MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP744172MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Neil2; Gm1212; Endonuclease 8-like 2; EC 3.2.2.-; EC 4.2.99.18; DNA glycosylase/AP lyase Neil2; DNA-(apurinic or apyrimidinic site) lyase Neil2; Endonuclease VIII-like 2; Nei homolog 2; NEH2; Nei-like protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-329
  • 氨基酸序列
    PEGPSVRKF HHLVSPFVGQ KVVKTGGSSK KLHPAAFQSL WLQDAQVHGK KLFLRFDPDE EMEPLNSSPQ PIQGMWQKEA VDRELALGPS AQEPSAGPSG SGEPVPSRSA ETYNLGKIPS ADAQRWLEVR FGLFGSIWVN DFSRAKKANK KGDWRDPVPR LVLHFSGGGF LVFYNCQMSW SPPPVIEPTC DILSEKFHRG QALEALSQAQ PVCYTLLDQR YFSGLGNIIK NEALYRARIH PLSLGSCLSS SSREALVDHV VEFSKDWLRD KFQGKERHTQ IYQKEQCPSG HQVMKETFGP PDGLQRLTWW CPQCQPQLSS KGPQNLPSS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  • 基因功能参考文献：
    1. NEIL2 plays an important role in long term genomic maintenance PMID: 26245904
    2. the beta2/beta3 loop where Lys50 is located in NEIL2 is important for DNA binding, presumably lies next to a phosphate-binding site, and may represent a target for regulation of the enzyme activity. PMID: 20175991
    3. Recombinant human DNA Polymerase beta and recombinant mpise NEIL2 associated with microtubules in situ and in vivo. PMID: 15725623
    4. Keap1 recruits NEH2 through binding to ETGE and DLG motifs. PMID: 16581765
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    FPG family
  • 数据库链接：

    KEGG: mmu:382913

    STRING: 10090.ENSMUSP00000045200

    UniGene: Mm.239490