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  4. Recombinant Mouse Epoxide hydrolase 1 (Ephx1), partial

Recombinant Mouse Epoxide hydrolase 1 (Ephx1), partial

  • 中文名称：
    小鼠Ephx1重组蛋白
  • 货号：
    CSB-YP880487MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ephx1重组蛋白
  • 货号：
    CSB-EP880487MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ephx1重组蛋白
  • 货号：
    CSB-EP880487MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ephx1重组蛋白
  • 货号：
    CSB-BP880487MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ephx1重组蛋白
  • 货号：
    CSB-MP880487MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ephx1
  • Uniprot No.：
  • 别名：
    Ephx1; Epoxide hydrolase 1; EC 3.3.2.9; Epoxide hydratase; Microsomal epoxide hydrolase; mEH
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol.
  • 基因功能参考文献：
    1. High epoxide hydrolase expression is associated with colonic inflammation. PMID: 29717038
    2. MEH appears to play a leading role in the hydrolysis of 8,9-epoxyeicosatrienoic acid and also contributes to the hydrolysis of other fatty acid epoxides. PMID: 28975360
    3. These findings show the critical role of soluble epoxide hydrolase S-nitrosation in cardiac ischemia-reperfusion injury. PMID: 28736260
    4. Data, including data from mutant strain of mice, suggest critical role of Ephx1 in regulation of vasodynamics (specifically regulation of cerebral blood flow) and suggest that deregulation of endogenous signaling pathways (such as eicosanoid metabolism) is undesirable gain of function associated with E404D variant of Ephx1. PMID: 26838043
    5. Expression of HBSP significantly increased the formation of BPDE-DNA adduct in benzo[alpha]pyrene-treated Huh-7 hepatoma cells, and this enhancement was blocked by knockdown of microsomal epoxide hydrolase PMID: 24758376
    6. sEH gene deletion is protective against ischemic stroke by a vascular mechanism linked to reduced hydration of circulating EETs PMID: 18369166
    7. EPHX1 in oviductal cells may enhance the development of cocultured embryos by protecting them from oxidative stress. PMID: 19321813
    8. The results suggest that epoxide intermediates mediate methamphetamine drug dependence and that astrocytic reactions of microsomal epoxide hydrolase protein are important in the endogenous modulation in response to methamphetamine drug dependence. PMID: 19598248

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  • 亚细胞定位：
    Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.
  • 蛋白家族：
    Peptidase S33 family
  • 数据库链接：

    KEGG: mmu:13849

    STRING: 10090.ENSMUSP00000047551

    UniGene: Mm.9075