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  4. Recombinant Mouse Erythropoietin receptor (Epor), partial

Recombinant Mouse Erythropoietin receptor (Epor), partial

  • 货号：
    CSB-YP007744MO1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP007744MO1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-MP007744MO1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Epor; Erythropoietin receptor; EPO-R
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.
  • 基因功能参考文献：
    1. these results have revealed that phosphorylation of Tyr-343, Tyr-460, and Tyr-464 in EpoR underlies JAK2 V617F mutant-induced tumorigenesis. PMID: 27998978
    2. A solution NMR study of the mouse erythropoietin receptor (mEpoR) comprising the transmembrane domain and the juxtamembrane regions reconstituted in dodecylphosphocholine (DPC) micelles. PMID: 26316120
    3. loss of function results in defective macrophage clearance of apoptotic cells in vivo PMID: 26872696
    4. These data indicate that EpoR signaling is associated with cardiac remodeling following chronic iron deficiency. PMID: 25715089
    5. We propose that the CID-dependent dimerization system combined with the EpoR intracellular domain and the Gata1 gene regulatory region generates a novel peroral strategy for the treatment of anemia. PMID: 25790231
    6. transmembrane domain and the juxtamembrane region of the erythropoietin receptor in micelles PMID: 25418301
    7. EpoR and its activity are downstream effectors of Klotho enabling it to function as a cytoprotective protein against oxidative injury. PMID: 23636173
    8. Expression of EPOR in rod photoreceptors, Muller cells, and amacrine, horizontal, and ganglion cells of the peripheral retina is not required for the maturation, function, and survival of these cells in aging tissue. PMID: 24644405
    9. Data from knockout mice suggest that adipose tissue-specific disruption of EPO receptor does not alter adipose tissue expansion, adipocyte morphology, insulin resistance, inflammation, or angiogenesis. PMID: 23885016
    10. the EPO-EPOR system may play a role in glucose metabolism within adipocytes. PMID: 23313788
    11. EPOR regulates transcriptome for primary progenitors, including Tnfr-sf13c as a novel mediator of EPO-dependent erythroblast formation. PMID: 22808010
    12. expression of EPOR decreased with the development of renal cortex PMID: 22844537
    13. enhanced activation of signaling pathways downstream of the EPO-receptor, indicate that SH2B1 is a negative regulator of EPO signaling. PMID: 22669948
    14. EPO/EPOR signaling from astrocyte to oligodendrocyte progenitor cells (OPC) prevents OPC damage under hypoxic/reoxygenation conditions. PMID: 21833990
    15. Postmortem neural precursor cells differentiate mostly in self-renewable neurons, show activation, and express both erythropoietin (EPO) and its receptor (EPO-R). PMID: 21324364
    16. expressed in both non-wounded and wounded skin tissue as well as in fibroblasts and keratinocytes PMID: 21894148
    17. Gata4 or Sp1 may limit the accessibility of the EpoR for binding of erythropoiesis-stimulating agents. PMID: 21029371
    18. Mice with transgenic expression of a constitutively active erythropoietin receptor isoform in pyramidal neurons of cortex and hippocampus exhibit enhancement of spatial learning, cognitive flexibility, social memory, and attentional capacities. PMID: 21527022
    19. The Epo/EpoR complex plays a critical role in the adhesion and migration of rat fibroblasts, and its functional inactivation is associated with PLC-gammal-dependent reduction of cell-matrix adhesion and this also affects cell migration. PMID: 21360263
    20. genetic ablation promotes Salmonella elimination PMID: 21256055
    21. These data provide evidence of a role for nitric oxide in erythropoietin activity in brain and suggest links between NO production, EpoR expression, and Epo signaling in neuroprotection. PMID: 20806411
    22. The phosphorylation of EpoR at Y479 is required for oncogenic signaling of JAK2 V617F mutant and that targeted disruption of this pathway has therapeutic utility. PMID: 21255641
    23. ubiquitination of the EpoR critically controls both receptor down-regulation and downstream signaling. PMID: 21183685
    24. Darbepoetin stimulates multiple cardioprotective mechanisms in infarcted myocardium to improve cardiac function independent of erythropoietin receptor-common beta-chain heteroreceptor. PMID: 20649603
    25. regional specific up-regulation of EPOR at an early stage after MPTP stimulus may represent a pro-survival mechanism against neurotoxin injury in Parkinsonian model PMID: 19537929
    26. rapid ligand depletion & replenishment of cell surface receptor are characteristic of EpoR; Epo-EpoR complexes & EpoR activation integrated over time correspond linearly to ligand input; relation depends on EpoR turnover PMID: 20488988
    27. the presence of EpoR is required to activate oncogenic signaling via the JAK2 mutant and STAT5, its interacting ability is a target for the treatment of these hematopoietic diseases. PMID: 20028972
    28. N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor PMID: 11779507
    29. Epo receptor cytoplasmic domain conformation is essential for the initiation of signal transduction PMID: 11997394
    30. developmental defect of PrlR(-/-) mammary epithelium is rescued by an exogenously expressed chimeric receptor (prl-EpoR) containing the PrlR extracellular domain joined to the EpoR transmembrane and intracellular domains PMID: 12381781
    31. demonstration of an essential role for Src pathway in regulating growth, proliferation, and cooperation with Epo-Receptor downstream from Kit PMID: 12486028
    32. C-hexosylation of the WSAWS motif did not play a role in the correct intracellular transport of sEPOR PMID: 12859190
    33. the function of JAK2-coupled but phosphotyrosine-null Epo form appears to be attenuated in several contexts and to be assisted in vivo by compensatory mechanisms. PMID: 12869513
    34. the Epo receptor Tyr-343 Stat5 pathway has a role in proliferative co-signaling with kit PMID: 12909618
    35. EpoR can be activated to different extents by homodimeric gp55 proteins, depending on the conformation of the gp55 protein dimer in the TM region PMID: 12930840
    36. erythropoietin receptor transmembrane segments self-interaction depends on a membrane-spanning leucine zipper PMID: 14602718
    37. Data suggest that the activity of the erythropoietin receptor is determined by the helical periodicity or orientation of the transmembrane and cytosolic domains. PMID: 14636581
    38. results elucidate a previously unrecognized hematopoietic cell survival pathway elicited by the EPOR, that requires Stat5 and is serum independent. PMID: 14662339
    39. a functional EPO-R may be necessary and sufficient for TPO to exert its mitogenic effects on erythroid cells. PMID: 15102474
    40. Knockout mice exhibit normal erythrocyte maturation, so receptor is not resquired for erythropoiesis PMID: 15456912
    41. the TM-JM junction of EpoR forms an N-terminal helix cap required for function PMID: 15657048
    42. Friend virus activates both sf-STK and the EPOR to cause deregulated erythroid proliferation and differentiation. PMID: 16174761
    43. In knockout mice, epoietein induced reticulocyte and erythroblast maturation were attenuated. PMID: 16332976
    44. analysis of gene expression induced by erythropoietin receptor structural variants PMID: 16380376
    45. model of the active and inactive conformations of the Epo receptor PMID: 16414957
    46. The classical EPOR is essential for EPO action during embryonic neurogenes & is important for adult neurogenesis and for migration of regenerating neurons during post-injury recovery. PMID: 16436614
    47. Stress erythropoiesis during anemia is rescued to wild type levels upon the selective restoration of an EpoR-phosphotyrosine-Stat5-binding site signaling axis. PMID: 16511603
    48. The vascular EpoR system plays an important role in angiogenesis in response to hindlimb ischemia through upregulation of the vascular endothelial growth factor/VEGF receptor system. PMID: 17293480
    49. In mice expressing an EpoR allele, compromised erythropoietin-induced podocalyxin expression correlated with enucleated red cells in bone marrow. PMID: 17403918
    50. Hypoxic downregulation of sEpoR is required for adequate ventilatory acclimatization to hypoxia. PMID: 17584830

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  • 亚细胞定位：
    [Isoform EPOR-F]: Cell membrane; Single-pass type I membrane protein.; [Isoform EPOR-S]: Secreted.
  • 蛋白家族：
    Type I cytokine receptor family, Type 1 subfamily
  • 组织特异性：
    Expressed in relatively mature erythroid progenitor cells and in EPO-responsive erythroleukemia cells.
  • 数据库链接：

    KEGG: mmu:13857

    STRING: 10090.ENSMUSP00000006397

    UniGene: Mm.2653