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  4. Recombinant Mouse F-box/LRR-repeat protein 21 (Fbxl21)

Recombinant Mouse F-box/LRR-repeat protein 21 (Fbxl21)

  • 货号：
    CSB-YP803845MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP803845MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP803845MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP803845MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP803845MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fbxl21
  • Uniprot No.：
  • 别名：
    Fbxl21; Fbl21; Fbxl3bF-box/LRR-repeat protein 21; F-box and leucine-rich repeat protein 21; F-box and leucine-rich repeat protein 3B; F-box/LRR-repeat protein 3B
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-434
  • 氨基酸序列
    MKRNNFSAVN KVVQSSPVVK QPKRGLCSSL RQTHALSVLL DWGTLPHHVI LQIFQYLPLI DRARASSVCR RWNEVFHIPD LWRKFEFELN QSATSYFKST HPDLIQQIIK KHAAHLQYVS FKVDSSTESA EAACDILSQL VNCSIQTLGL ISTAKPSFMN VPKSHFVSAL TVVFVNSKSL SSIKIEDTPV DDPSLKILVA NNSDTLRLLK MSSCPHVSSD GILCVADHCQ GLRELALNYY ILSDEILLAL SSETHVNLEH LRIDVVSENP GQIKFHSIKK RSWDALIKHS PRVNVVMYFF LYEEEFEAFF KEETPVTHLY FGRSVSRAIL GRIGLNCPRL IELVVCANGL LPLDSELIRI AKHCKNLTSL GLSECEVSCS AFVEFVRLCG RRLTQLSIME EVLVPDDRYT PDEVHTEVSK HLGRVWFPDV MPIW
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities.
  • 基因功能参考文献：
    1. FBXL21 plays a dual role: protecting CRY from FBXL3 degradation in the nucleus and promoting CRY degradation within the cytoplasm. PMID: 23452855
    2. Study shows that FBXL21 ubiquitinates CRY1 and CRY2 and that, surprisingly, FBXL21 stabilizes CRYs. FBXL21 localizes predominantly in the cytosol, whereas FBXL3 is present in the nucleus. PMID: 23452856
  • 亚细胞定位：
    Cytoplasm, cytosol. Nucleus. Note=Mainly localizes in the cytosol. Present at low level in the nucleus.
  • 组织特异性：
    Expressed in the hypothalamus, especially in the suprachiasmatic nucleus (SCN). Expression is driven by the core-clock. There is a pronounced diurnal and circadian expression rhythms rising rapidly at the start of the day and declining at the onset of the
  • 数据库链接：

    KEGG: mmu:213311

    STRING: 10090.ENSMUSP00000035248

    UniGene: Mm.233904