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  4. Recombinant Mouse Fanconi anemia group G protein homolog (Fancg)

Recombinant Mouse Fanconi anemia group G protein homolog (Fancg)

  • 中文名称：
    小鼠Fancg重组蛋白
  • 货号：
    CSB-YP887654MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Fancg重组蛋白
  • 货号：
    CSB-EP887654MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Fancg重组蛋白
  • 货号：
    CSB-EP887654MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Fancg重组蛋白
  • 货号：
    CSB-BP887654MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Fancg重组蛋白
  • 货号：
    CSB-MP887654MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fancg
  • Uniprot No.：
  • 别名：
    FancgFanconi anemia group G protein homolog; Protein FACG
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-623
  • 氨基酸序列
    MSSQVIPALP KTFSSSLDLW REKNDQLVRQ AKQLTRDSRP SLRRQQSAQD TLEGLRELLL TLQGLPAAVP ALPLELTVLC NCIILRASLV QAFTEDLTQD LQRGLERVLE AQHHLEPKSQ QGLKELWHSV LSASSLPPEL LPALHCLASL QAVFWMSTDH LEDLTLLLQT LNGSQTQSSE DLLLLLKSWS PPAEESPAPL ILQDAESLRD VLLTAFACRQ GFQELITGSL PHAQSNLHEA ASGLCPPSVL VQVYTALGAC LRKMGNPQRA LLYLTEALKV GTTCALPLLE ASRVYRQLGD RAAELESLEL LVEALSATHS SETFKSLIEV ELLLPQPDPA SPLHCGTQSQ AKHLLASRCL QTGRAEDAAE HYLDLLAMLL GGSETRFSPP TSSLGPCIPE LCLEAAAALI QAGRALDALT VCEELLNRTS SLLPKMSSLW ENARKRAKEL PCCPVWVSAT HLLQGQAWSQ LKAQKEALSE FSQCLELLFR TLPEDKEQGS DCEQKCRSDV ALKQLRVAAL ISRGLEWVAS GQDTKALSDF LLSVQICPGN RDGSFYLLQT LKRLDRKNEA SAFWREAHSQ LPLEDAAGSL PLYLETCLSW IHPPNREAFL EEFGTSVLES CVL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.
  • 基因功能参考文献：
    1. Hematopoietic stem cells of Fancg-/- mice Impaired functionality and homing. PMID: 21968513
    2. null mutations in Fanca or Fancg are fully epistatic PMID: 22036606
    3. the FA pathway (FancG) is not involved in regulating the outcome of SHM in mammals and it appears dispensable for class switch recombination PMID: 21209924
    4. Data show that Fancd2(-/-) mice displayed a higher magnitude of chromosomal breakage and micronucleus formation than the wild-type or Fancg(-/-) mice. PMID: 21118969
    5. Double-mutant Fancc(-/-);Fancg(-/-) mice develop spontaneous hematologic sequelae including bone marrow failure, acute myeloid leukemia, myelodysplasia and complex random chromosomal abnormalities that the single-mutant mice do not. PMID: 20606166
    6. Mice deficient in Fancg were not anemic, but showed hypogonadism, impaired fertility, and hypersensitivity to mitomycin C PMID: 11823446
    7. Characterization and expression of the murine Fanconi anaemia gene product PMID: 11918676
    8. FANCG is required for efficient homologous recombination-mediated repair of at least some types of DNA double-strand breaks PMID: 12861027
    9. Fancg deeficient mouse cells display normal telomere length, normal telomerase activity, and normal chromosome end-capping PMID: 15319283
    10. a deletion mutation in the FANCG gene (c.637_643delTACCGCC) was present in 82% of Fanconi anemia patients in the black populations of Southern Africa PMID: 15657175
    11. Ataxia telangiectasia mutated and Fanconi anemia genes function in parallel and compensatory roles to maintain genomic integrity and cell viability. PMID: 17431503
    12. Fancg knockout mice presented with microcephalies and a decreased neuronal production in developing cortex and adult brain, demonstrating a critical role for Fanconi pathway in neural stem and progenitor cells during developmental and adult neurogenesis. PMID: 18239686
    13. loss of the murine homologue of FANCG (Fancg) results in a defect in mesenchymal stem/progenitor cells proliferation and in their ability to support the adhesion and engraftment of murine syngeneic hematopoietic stem/progenitor cells in vitro or in vivo PMID: 19129541

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Highest expression levels in spleen, thymus and testis.
  • 数据库链接：

    KEGG: mmu:60534

    STRING: 10090.ENSMUSP00000030165

    UniGene: Mm.23122