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  4. Recombinant Mouse Fascin-2 (Fscn2)

Recombinant Mouse Fascin-2 (Fscn2)

  • 货号：
    CSB-YP656976MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP656976MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP656976MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP656976MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP656976MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fscn2
  • Uniprot No.：
  • 别名：
    Fscn2Fascin-2; Retinal fascin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-492
  • 氨基酸序列
    MPTNGLHQVL KIQFGLVNDA DRYLTAESFG FKVNASAASL KRKQIWVLEP DPGQGTAVLF RSSHLGRYLS AEEDGRVACE MDQPGRDCRF LVLPQPDGRW VLQSEPHGRF FGGIEDRLSC FATAISPAEL WTVHLAIHPQ AHLLSVSRRR YVHLCLQEDE MAADGDMPWG VDALVTLIFQ SRRYCLKSYD SRYLRSDGRL VWEPEAHACY TLEFKAGKLA FKDCDGRYLA PVGPAGTLKA GRNTRPSKDE LFDLEQSHPQ VVLVAANRRY ISVRQGINVS ANQDEELGHE TFLMQIDQET KKCTFYSSTG GYWTLVTHGG IQATATQVSA NTMFEIEWHG RRVALKASNG RFVCMKKNGQ LAAISDFVGE DELFTLKLIN RPLLVLRGLD GFVCHRRGSN QLDTNRSTYD VFHLSFRDGA YQIRGRGGGF WYTGSHGSVC SDGDLAEDFL FEFRERGRLA IRALSGKYLR GGASGLLRAD ADLPVGEALW EY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis. Important for maintaining functional hair-cell bundles in the inner ear. May stiffen the longer stereocilia of hair-cell bundles in the inner ear enabling better force transmission to tip links.
  • 基因功能参考文献：
    1. The results show that cross-talk through CD40-CD40L signaling drives elevated fascin expression in DCs to support acquisition of full T-cell responses. PMID: 28369442
    2. A quantitative trait locus on chromosome 5 modifies hearing loss associated with the fascin-2 variant of DBA/2J mice. PMID: 26092689
    3. The results of this study demonistrated that fascin-2 crosslinks function to slow actin depolymerization at stereocilia tips to maintain stereocilia length. PMID: 23658152
    4. Mutation in the Fscn2 gene underlies the early onset progressive hearing loss of DBA/2J mice attributed to the ahl8 locus. PMID: 20660251
  • 相关疾病：
    Defects in Fscn2 lead to hair-cell degeneration in the inner ear and are a key contributor to the early-onset, age-related hearing loss (prebycusis) phenotype when in combination with waltzer cadherin 23 mutant.
  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell projection, stereocilium. Note=Found mostly in longer hair-cell stereocilia and, in all stereocilia, present in gradient with the highest concentration at stereocilia tips.
  • 蛋白家族：
    Fascin family
  • 组织特异性：
    Expressed in the inner ear. Abundant in the utricle.
  • 数据库链接：

    KEGG: mmu:238021

    STRING: 10090.ENSMUSP00000026445

    UniGene: Mm.481403