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  4. Recombinant Mouse Fibroblast growth factor 13 (Fgf13)

Recombinant Mouse Fibroblast growth factor 13 (Fgf13)

  • 中文名称：
    小鼠Fgf13重组蛋白
  • 货号：
    CSB-YP008619MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Fgf13重组蛋白
  • 货号：
    CSB-EP008619MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Fgf13重组蛋白
  • 货号：
    CSB-EP008619MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Fgf13重组蛋白
  • 货号：
    CSB-BP008619MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Fgf13重组蛋白
  • 货号：
    CSB-MP008619MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fgf13
  • Uniprot No.：
  • 别名：
    Fgf13; Fhf2Fibroblast growth factor 13; FGF-13; Fibroblast growth factor homologous factor 2; FHF-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-245
  • 氨基酸序列
    MAAAIASSLI RQKRQARERE KSNACKCVSS PSKGKTSCDK NKLNVFSRVK LFGSKKRRRR RPEPQLKGIV TKLYSRQGYH LQLQADGTID GTKDEDSTYT LFNLIPVGLR VVAIQGVQTK LYLAMNSEGY LYTSEHFTPE CKFKESVFEN YYVTYSSMIY RQQQSGRGWY LGLNKEGEIM KGNHVKKNKP AAHFLPKPLK VAMYKEPSLH DLTEFSRSGS GTPTKSRSVS GVLNGGKSMS HNEST
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. May regulate voltage-gated sodium channels transport and function. May also play a role in MAPK signaling. Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons.; seems not to be involved in neuroblast polarization and migration but regulates axon branching.
  • 基因功能参考文献：
    1. Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors PMID: 27916441
    2. FHF2 has an essential role in dictating myocardial excitability and conduction that safeguards against temperature-sensitive conduction failure PMID: 27701382
    3. regulator of caveolae-mediated mechanoprotection and adaptive hypertrophic signaling in cardiomyocytes PMID: 28461495
    4. identified two novel native phosphorylation sites in the C terminus of NaV1.5 that impair FGF13-dependent regulation of channel inactivation and may contribute to CaMKIIdeltac-dependent arrhythmogenic disorders in failing hearts. PMID: 28882890
    5. the FGF13/Nav1.7 complex is essential for sustaining the transmission of noxious heat signals PMID: 28162808
    6. These results implicate that FGF13 is a critical cardiac Na(+) channel modulator and Fgf13 knockout mice have increased arrhythmia susceptibility in the setting of Na(+) channel blockade. PMID: 28119060
    7. FGF13 down-regulated Spry1 protein expression, activating the ERK1/2 pathway by phosphorylation and leading to C2C12 cell differentiation inhibition. PMID: 26230950
    8. Fibroblast growth factor homologous factors (FGF11-14) modulate cardiac calcium channels. PMID: 23804213
    9. FGF13 has a role in hair follicle growth and in the hair cycle PMID: 23603273
    10. Genetic deletion of FGF13 in mice results in neuronal migration defects in both the neocortex and the hippocampus. FGF13-deficient mice also exhibit weakened learning and memory. PMID: 22726441
    11. Fibroblast growth factor homologous factor 13 regulates Na(V)1.5 sodium channels and conduction velocity in murine hearts. PMID: 21817159
    12. FGF-13 may play a role in regulating the function of cells in the bulge region and basal layer of the epidermis. PMID: 15140207

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  • 亚细胞定位：
    Cell projection, filopodium. Cell projection, growth cone. Cell projection, dendrite. Nucleus. Cytoplasm. Note=Not secreted. Localizes to the lateral membrane and intercalated disks of myocytes.; [Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm.
  • 蛋白家族：
    Heparin-binding growth factors family
  • 组织特异性：
    Detected in brain, eye and heart. In brain, the different isoforms display different patterns of expression. Expressed in brain and heart (at protein level). Isoform 3 is highly expressed in cardiac myocytes while isoform 1 is the most abundant in brain.
  • 数据库链接：

    KEGG: mmu:14168

    STRING: 10090.ENSMUSP00000033473

    UniGene: Mm.7995