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  4. Recombinant Mouse Fibroblast growth factor receptor 1 (Fgfr1), partial

Recombinant Mouse Fibroblast growth factor receptor 1 (Fgfr1), partial

  • 货号：
    CSB-YP008642MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP008642MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP008642MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP008642MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP008642MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Fgfr1; FlgFibroblast growth factor receptor 1; FGFR-1; bFGF-R-1; EC 2.7.10.1; Basic fibroblast growth factor receptor 1; MFR; Proto-oncogene c-Fgr; CD antigen CD331
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
  • 基因功能参考文献：
    1. Oligodendroglial FGFR1 deficient mice (-/-) showed a significantly ameliorated disease course in MOG35-55 -induced experimental autoimmune encephalomyelitis. Less myelin and axonal loss, and reduced lymphocyte and macrophage/microglia infiltration were found in Fgfr1(-/-) mice. Reduction in disease severity in Fgfr1(ind-/-) mice was accompanied by ERK/AKT phosphorylation, and increased expression of BDNF and TrkB. PMID: 28117910
    2. the close proximity between AcSDKP and FGFR1 was essential for the suppression of TGFbeta/smad signaling and EndMT associated with MAP4K4 phosphorylation (P-MAP4K4) in endothelial cells. PMID: 28771231
    3. FGFR1 is a driver oncogene in de novo, FGFR1-overexpressing acute myeloid leukemia PMID: 27391347
    4. Visceral adipose tissue-derived factors stimulate cell transformation through FGFR-1. PMID: 28783178
    5. MAPK cascades participate in osteogenesis, but only the ERK signaling pathway responds to FGFR1. PMID: 28537241
    6. It is well accepted that myelin is a biologically active membrane in active communication with the axons. However, the axonal signals, the receptors on myelin, and the integration of intracellular signaling pathways emanating downstream from these receptors that drive the growth of the myelin sheath remain poorly understood in the CNS. This study brings up the intriguing possibility that FGF receptor 2, in the oligodendr PMID: 28193689
    7. These new findings reveal that the FGF21-betaKlotho-FGFR1 signaling axis plays roles in maintaining phospholipid homeostasis and the dynamic functions of the lipid droplet, whereas protecting against ER stress, and suggest a potential link of phospholipid biosynthesis, lipid droplet dynamics, ER stress, and energy homeostasis in adipose tissue coordinated by this signaling axis. PMID: 27690692
    8. FGFR1OP2-FGFR1 fusion in hematopoietic stem cells induced myeloid leukemia and T-cell lymphoma in a mouse model. PMID: 26589915
    9. MiR-214 was up-regulated in mesenchymal stem cells of osteoporotic mice and down-regulated during osteoblast differentiation of mesenchymal stem cells. FGFR1 is a direct target of miR-214. PMID: 26872365
    10. demonstrated that Id1 and E2-2 are critical regulators of EPCs function in vitro. Id1 interacts with E2-2 and relieves the E2-2-mediated repression of FGFR1 and VEGFR2 expression to modulate EPCs functions PMID: 26476925
    11. FGF receptor 1-mediated anosmin-1 activity plays a crucial role in the continuous remodelling of the adult olfactory bulb. PMID: 25300351
    12. Fgfr1 and Fgfr2 in the palatal and mandibular mesenchyme have roles in regulating shelf medial wall protrusion and growth of the mandible to coordinate the craniofacial tissue movements that are required for palatal shelf elevation PMID: 26250517
    13. Data suggest that signal transduction via Fgf23/Fgfr1 and calcitriol/calcitriol receptor have opposite roles in innate immunity; Fgf23 suppresses arginase-1 expression in macrophages; calcitriol stimulates arginase-1 expression in macrophages. PMID: 26762170
    14. FGFR1 has dual functions to directly regulate proximal and distal tubule phosphate and calcium reabsorption, indicating a physiological role of FGFR1 signaling in both phosphate and calcium homeostasis. PMID: 26839958
    15. Data demonstrate an essential role for FGFR1 and FGFR2 in endothelial cells for cardiac functional recovery and vascular remodeling following in vivo cardiac ischemia-reperfusion injury, without affecting the cardiac hypertrophic response. PMID: 26747503
    16. Activation of FGFR1 is essential for the high levels of FGF23 in acute and chronic experimental uremia. PMID: 26311115
    17. The results of this study concluded that since the OPC response was not altered in Fgfr1/Fgfr2 dKO mice either after initial demyelination or after chronic demyelination. PMID: 25913734
    18. a transplantable Wnt1/inducible fibroblast Arowth factor receptor (FGFR) 1 mouse mammary tumor model. PMID: 26581390
    19. Conditional knockout of Fgfr1 revealed stage- and tissue-specficic roles of FGF signaling in multiple processes of external genitalia development among the 3 tissue layers at each developmental stage. PMID: 25820239
    20. Nuclear FGFR1 targets the consensus sequences of transcription factors known to engage CREB-binding protein, a common coregulator of transcription and established binding partner of nuclear FGFR1. PMID: 25923916
    21. FGFR1 signaling in hypertrophic chondrocytes is attenuated by the Ras-GAP neurofibromin during endochondral bone formation PMID: 25616962
    22. Frs2 binding to Fgfr1 has the most pleiotropic functions in development but also that the receptor uses multiple proteins additively in vivo PMID: 26341559
    23. ctivation of autocrine/paracrine FGF pathways is involved in the pathogenesis of Hyp through FGFR1-dependent regulation of FGF23 by both transcriptional and post-transcriptional mechanisms. PMID: 25089825
    24. miR-34a negatively modulated anesthesia-induced hippocampal neurotoxicity via FGFR1. PMID: 25400756
    25. Endothelial cell-specific deletion of Fgfr1 enhanced endothelial-to-mesenchymal transition in knockout mice. FGFR1 is the key regulator of TGFbeta signaling and EndMT development. PMID: 25249657
    26. Fgfr1 and Fgfr2 have synergistic roles in maintaining nephron progenitors. PMID: 25641696
    27. This study suggests that targeted deletion of Fgfr1 in osteoblasts enhances mobilization of endothelial progenitor cells into peripheral blood through up-regulating SDF-1alpha secretion from osteoblasts. PMID: 25285038
    28. Fgfr1 inactivation in the mouse telencephalon results in impaired maturation of interneurons expressing parvalbumin. PMID: 25116473
    29. FGFR overexpression results in HCM with a dynamic outflow tract obstruction, and may serve as a unique model of HCM. PMID: 24349409
    30. Data suggest that fibroblast growth factor receptor type 1 (FGFR1) isoform expression can be used as a predictive biomarker for therapeutic application of its kinase inhibitors. PMID: 24618085
    31. This data shows that primitive endoderm cells of the outer layer of embryoid bodies gradually polarise, and formation of a polarised primitive endoderm layer requires the Fgf receptor/Erk signalling pathway. PMID: 24752320
    32. Canonical Wnt-, Hh-, and Fgfr1/Fgfr2-signalling are dispensable for epicardial development, but Pdgfra-signalling is crucial for the differentiation of cardiac fibroblasts from epicardium-derived cells. PMID: 24000064
    33. Analysis of a mutant Fgfr1 allele, unable to bind to the adaptor protein, Frs2/3, indicates that Sox2 maintenance can be regulated by MAP kinase. PMID: 24465223
    34. Evidence that the novel receptor FGFRL1 signals indirectly via FGFR1. PMID: 24026051
    35. Data indicatethat deleting Fgfr1 in neural crest cells caused defects in both palate shelf epithelium and mesenchyme and led to cleft palate. PMID: 23754280
    36. CNTRL and FGFR1 have roles in myeloid and lymphoid malignancies in both human and mouse models PMID: 23777766
    37. work reveals the central role of FGFR1 in the regulation of FGF23 production and signal transduction, and has implications in the pathogenesis of FGF23-related hypophosphatemic disorders PMID: 23451204
    38. FGF receptors 1 and 2 are key regulators of keratinocyte migration in vitro and in wounded skin. PMID: 22992463
    39. Data indicate that mice carrying the fgfr1 null allele survived significantly longer than those without fgfr1 deletion. PMID: 23576558
    40. Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein kinase C(epsilon) regulates Ras/mitogen-activated protein kinase signaling and neuronal differentiation. PMID: 23564461
    41. fibroblast growth factor receptor (FGFR)1 and FGFR2 are found in a variety of embryonic olfactory cells, including olfactory ensheathing cells and their precursors, and neuronal nestin+ and Mash1+ progenitors PMID: 23137310
    42. a significant reduction in outgrowth potential was observed upon the deletion of both FGFR1 and FGFR2, documenting the requirement for functional FGFR signaling in mammary stem cells during development. PMID: 23097355
    43. our results demonstrate that FGFR1 is crucial for S115 breast cancer cell proliferation and tumor growth and angiogenesis, whereas FGFR2 and FGFR3 are less critical for the growth of these cells PMID: 23185502
    44. Phosphate-independent effects of high-molecular weight (HMW) isoforms in vitro may be directly mediated in part via FGF23 and HMW isoforms signal via FGF23/FGFR/MAPK to inhibit bone formation in vitro. PMID: 22836867
    45. transgenic mice with reduced FGF signaling have not only suboptimal reproductive physiology, but also suboptimal maternal behavior. PMID: 22950531
    46. Disruption of FGFR-1 in adult mouse articular chondrocytes inhibits the progression of cartilage degeneration. PMID: 22833219
    47. Disrupted cerebellar size and laminar architecture resulting from loss of FGFR1 signaling impair motor learning and coordination in FGFR double knockout mice. PMID: 22578469
    48. These data confirm that both FGF and VEGF signaling are necessary for the maintenance of vascular morphogenesis PMID: 22761819
    49. Ascorbic acid rescues cardiomyocyte development in Fgfr1(-/-) murine embryonic stem cells. PMID: 22735182
    50. Data indicate that FGF receptor 1 (FGFR1) conditional knockout mice showed defects in both proliferation and subsequent mobilization of hematopoietic stem and progenitor cell (HSPC). PMID: 22802336

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.; [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 5]: Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    KEGG: mmu:14182

    STRING: 10090.ENSMUSP00000081041

    UniGene: Mm.265716