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  4. Recombinant Mouse Fibroblast growth factor receptor substrate 2 (Frs2)

Recombinant Mouse Fibroblast growth factor receptor substrate 2 (Frs2)

  • 货号：
    CSB-YP009004MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP009004MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP009004MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP009004MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP009004MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Frs2; Frs2aFibroblast growth factor receptor substrate 2; FGFR substrate 2; FGFR-signaling adaptor SNT; FRS2-alpha; Suc1-associated neurotrophic factor target 1; SNT-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-508
  • 氨基酸序列
    GSCCSCPDK DTVPDNHRNK FKVINVDDDG NELGSGVMEL TDTELILYTR KRDSVKWHYL CLRRYGYDSN LFSFESGRRC QTGQGIFAFK CARAEELFNM LQEIMQNNSI NVVEEPVVER SSHQTELEVP RTPRTPTTPG LGAQNLPNGY PRYPSFGDAS SHPSSRHPSV GSARLPSVGE ESTHPLLVAE EQVHTYVNTT GVQEERKNRA SVHVPPEARV SNAESNTPKE EPSNPEDRDP QVLLKPEGVR FVLGPTPVQK QLMEKEKLEQ LGKDPVSGSG AGNTEWDTGY DSDERRDVPP VNKLVYENIN GLSIPSASGV RRGRLTSTST SDTQNINNSA QRRPALLNYE NLPSLPPVWE ARKLSRDEDD NLGPKTPSLN GYHNNLDPMH NYVNTENVTV PASAHKIDYS KRRDCTPTVF NFDIRRPSLE HRQLNYIQVD LEGGSDSDNP QTPKTPTTPL PQTPTRRTEL YAVIDIERTA AMSNLQKALP RDDGTSRKTR HNSTDLPM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
  • 基因功能参考文献：
    1. FRS2alpha-mediated pathways are essential for the FGF15/FGF19-FGFR4 signaling axis to control bile acid homeostasis. PMID: 25056539
    2. controlsConclusionFrs2alpha(ST-/-) embryos have aberrant ureteric induction sites, improper ureteral insertion, shortened intravesicular lengths, and VUR PMID: 29135976
    3. Embryonic day 18.5 Six2Frs2alphaKO kidneys were hypoplastic and not cystic, postnatal day (P) 7 mutants had proximal tubular-derived cysts that nearly replaced the renal parenchyma by P21. Mutants had high proximal tubular proliferation rates and interstitial fibrosis, similar to known polycystic kidney disease models. PMID: 27853247
    4. Fgfr signaling in nephron progenitors appears to be mediated predominantly by Frs2alpha. PMID: 25641696
    5. Analysis of a mutant Fgfr1 allele, unable to bind to the adaptor protein, Frs2/3, indicates that Sox2 maintenance can be regulated by MAP kinase. PMID: 24465223
    6. data from two models showed that FRS2 played different roles in the regulation of two activity levels of the ERK pathway components in the epididymis. PMID: 23782834
    7. Genetic evidence further supports that the formation of an Frs2alpha-Shp2 complex and its recruitment to FGF receptors are crucial for downstream ERK signaling in this process. PMID: 23720040
    8. Frs2alpha enhances fibroblast growth factor-mediated survival and differentiation in lens development. PMID: 23136392
    9. a novel signaling network containing FRS2, CAP and flotillin-1 PMID: 22235335
    10. FRS2alpha-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity. PMID: 22207710
    11. The FGF signaling axis activates mTOR via the FGF receptor substrate 2alpha (FRS2alpha)-mediated PI3K/Akt pathway, and suppresses autophagy activity in MEFs. PMID: 21927580
    12. although Fgfr2 and Frs2alpha have crucial roles in the ureteric lineage, they appear to act separately and additively. PMID: 21350013
    13. Msx2 and Runx2 likely function together to induce PC-1 gene expression in osteoblastic cells and FGF signaling stimulates Msx2 transcriptional activity through the Frs2 mediated MAPK signaling pathway PMID: 20803545
    14. FRS2alpha fine-tunes the FGF2-signaling to control self-renewal and proliferation of neural stem cells through Hes1. PMID: 20652960
    15. Data show that PEA-15 prevents ERK1/2 localization to the plasma membrane, thereby inhibiting ERK1/2-dependent threonine phosphorylation of FRS2alpha to promote activation of the ERK1/2 MAP kinase pathway. PMID: 20032303
    16. Trophoblast stem cell FRS2alpha mediates activation of the ERK pathway to enhance Cdx2 expression in response to FGF4. Cdx2 in turn binds to an FGF4-responsive enhancer element of the promoter region of Bmp4, leading to production and secretion of Bmp4. PMID: 19890878
    17. Frs2alpha and Frs2beta have distinct spatio-temporal expression patterns in mouse embryos PMID: 15094036
    18. FGFR kinase regulates the cell cycle through phosphorylation-dependent release of Cks1 from FGFR substrate 2 PMID: 15513912
    19. FRS2-dependent SRC activation is required for FGFR-induced phosphorylation of Sprouty and suppression of ERK activity PMID: 15564375
    20. explore the role of signaling pathways downstream of FRS2alpha in eye development by analyzing the phenotypes of mice that carry point mutations in either the Grb2-or the Shp2-binding sites of FRS2alpha PMID: 15569927
    21. experiments underscore the critical role of FRS2alpha in mediating multiple processes during embryonic development and reveal a potential new link between FGF and Bmp4 signaling pathways in early embryogenesis PMID: 15870281
    22. Shp2-binding sites on FRS2alpha play an important role in neural progenitor cells (NSPC) proliferation but are dispensable for NSPC self-renewing capacity after FGF2 stimulation PMID: 16239343
    23. Generation of an Frs2alpha conditional null allele. PMID: 17868091
    24. Results suggest that although the tyrosine autophosphorylation sites of FGFR1 did not constitute the binding sites for FRS2alpha, phosphorylation of these residues was essential for optimal interaction with FRS2alpha. PMID: 17901128
    25. The number of carotid sinus nerve fibers that reached the carotid bifurcation region was markedly decreased, and baroreceptor fiberswere absent from the basal part of the internal carotid artery in FRS2 alpha(2F/2F) mutant mice. PMID: 18177855
    26. FRS2alpha is uniformly expressed in the epithelial cells of developing prostates, whereas it is expressed only in basal cells of the mature prostate epithelium. PMID: 18184727
    27. an important function for FRS2 is to concentrate RET in membrane foci, leading to an engagement of specific signaling complexes localized in these membrane domains PMID: 18189271
    28. FRS2alpha (FRS2), an adaptor protein that links FGF receptor kinases to multiple signaling pathways, mediates crucial aspects of fibroblast growth factor-dependent outflow tract development in mouse. PMID: 18832393
    29. role in development and growth of neural progenitor cells PMID: 19149625
    30. separation, migration, and survival of the pharyngeal organs were impaired in the FRS2alpha(2F/2F) mutants PMID: 19235715
    31. the renal hypoplasia observed in Frs2alpha(UB-/-) mice is likely secondary to decreased Ret and Wnt11 expression PMID: 19741018

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  • 亚细胞定位：
    Membrane; Lipid-anchor.
  • 组织特异性：
    Ubiquitous. Expression is highest in brain, kidney, lung and testis.
  • 数据库链接：

    KEGG: mmu:327826

    STRING: 10090.ENSMUSP00000020381

    UniGene: Mm.135965