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  4. Recombinant Mouse Fibroblast growth factor receptor substrate 3 (Frs3)

Recombinant Mouse Fibroblast growth factor receptor substrate 3 (Frs3)

  • 货号：
    CSB-YP009005MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP009005MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP009005MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP009005MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP009005MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Frs3
  • Uniprot No.：
  • 别名：
    Frs3; Frs2b; Fibroblast growth factor receptor substrate 3; FGFR substrate 3; FRS2-beta
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-492
  • 氨基酸序列
    GSCWSCLDR DSVPHNHPTK FKVTNVDDEG VELGSGVMEL TQSELVLHLH QREAVRWPYL CLRRYGYDSN LFSFESGRRC QTGQGIFAFK CSRAEDIFNL LQDLMQCNSI NVTEEPVIIT RSSHPPELDL PRGPPQPAGY TVSGFSNGFP GCPGEGPRFS SAPRRPSTSS LRHPSPGEES THTLIASEEQ SHTYVNTPTG DEDGRSRHCL QPLPEGRVPL PAQTQGSDQR DPQVLLQPGQ VKFVLGPTPA RRQVMKCQSL CPGMQDPPHH NNNEGPSECP AQPKCTYENV SGGLQQGAGW RLSPEERGWS GLAHRRAALL HYENLPPLPP VWESQGQQPG GEAGDDGDSR DGLTPSSNGF PDGEEDETPL QKPTSTRASA RSHSGFPVPL TRRRGSPRVF NFDFRRQGPE PPRQLNYIQV ELKGWGTARP KGPQNPSVSG APGPTPHPVR SSDSYAVIDL KKTAAMSDLQ RALPRDDGAV RKTRHNSTDL PL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.
  • 基因功能参考文献：
    1. Analysis of a mutant Fgfr1 allele, unable to bind to the adaptor protein, Frs2/3, indicates that Sox2 maintenance can be PMID: 24465223
    2. data indicate that the fibroblast growth factor receptor substrate 2 and fibroblast growth factor receptor substrate 3 adapters may have a role in thyroid carcinogenesis triggered by TRK oncogenes PMID: 12586769
    3. Some essential functions of Fgfr1 are mediated by Frs-independent signaling. PMID: 16421190
    4. ULK2, by interaction with FRS2/3 and inhibition of SynGAP, functions to negatively regulate tyrosyl phosphorylation of signaling proteins downstream of FGFR1. PMID: 16887332
    5. SNT family proteins may play significant roles in cellular transformation triggered by NPM-ALK. PMID: 17086210
    6. The results showed that the interaction of full-length FRS2beta with FGFR1 was not enhanced by activation of the receptor kinase. PMID: 17901128
    7. Prominent expression of Frs2beta protein in neural cells and its association with intracellular vesicles is reported. PMID: 19187780

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  • 亚细胞定位：
    Membrane; Lipid-anchor.
  • 数据库链接：

    KEGG: mmu:107971

    STRING: 10090.ENSMUSP00000108921

    UniGene: Mm.392206