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  4. Recombinant Mouse Fidgetin (Fign)

Recombinant Mouse Fidgetin (Fign)

  • 货号：
    CSB-YP008676MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP008676MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP008676MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP008676MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP008676MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fign
  • Uniprot No.：
  • 别名：
    FignFidgetin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-759
  • 氨基酸序列
    MISSTSVYGL KMQWTPEHAQ WPEQHFDITS TTRSPAHKVE AYRGHLQRTY QYAWANDDIS ALTASNLLKK YAEKYSGILE GPVDRPVLSN YSDTPSGLVN GRKNDSEPWQ PSLNSEAVYP MNCVPDVITA SKAGVSSALP PVDVSASIGS SPGVASNLTE PSYSSSTCGS HTVPSLHAGL PSQEYAPGYN GSYLHSTYSS QATPALPSPH PSPLHSSGLL QPPPPPPPPP ALVPGYNGTS NLSSYSYPSA SYPPQTAVGS GYSPGGAPPP PSAYLPSGIP APTPLPPTTV PGYTYQGHGL TPIAPSALTN NSASSLKRKA FYMAGQGDMD SSYGNYSYGQ QRSTQSPMYR MPDNSISNSN RGNGFDRNAE TSSLAFKPTK QLMPSEQQRK FSSQSSRALT PPSYSTAKNS LGSRSSESFG KYTSPVMSEH GDDHRQLLAH PIQGPGLRAA TSSNHSVDEQ LKNTDTHLID LVTNEIITQG PPVDWSDIAG LDLVKAVIKE EVLWPVLRSD AFSGLTALPR SILLFGPRGT GKTLLGRCIA SQLGATFFKI AGSGLVAKWI GEAEKIIHAS FLVARCRQPS VIFVSDIDML LSSQVSEEHS PVSRMRTEFL MQLDTVLTSA EDQIVVICAT SKPEEIDESL RRYFMKRLLI PLPDSTARHQ IIVQLLTQHN YCLNDKEFAL LVQRTEGFSG LDVAHLCQEA AVGPLHAMPA TDLSAIMPSQ LRPVTYQDFE NAFCKIQPSI SQKELDMYVE WNKMFGCSQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, suppressing microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome.
  • 基因功能参考文献：
    1. Functional characterization of fidgetin. PMID: 15707573
    2. fidgetin co-localized with endogenous AKAP95 in the nuclear matrix; AKAP95 mutant mice are surprisingly viable with no overt phenotype;mice carrying both Akap95 and fidget mutations die soon after birth due to cleft palate PMID: 16751186
  • 相关疾病：
    Defects in Fign are characterized by a side-to-side head-shaking and circling behavior, due to reduced or absent semicircular canals. Diseased mice also have small eyes, associated with cell-cycle delay and insufficient growth of the retinal neural epithelium, and lower penetrance skeletal abnormalities, including pelvic girdle dysgenesis, skull bone fusions and polydactyly.
  • 亚细胞定位：
    Nucleus matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    AAA ATPase family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    KEGG: mmu:60344

    STRING: 10090.ENSMUSP00000122855

    UniGene: Mm.130769