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Recombinant Mouse Filensin (Bfsp1)

  • 中文名称：
    Recombinant Mouse Filensin(Bfsp1),Yeast
  • 货号：
    CSB-YP002680MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Filensin(Bfsp1),Yeast
  • 货号：
    CSB-EP002680MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Filensin(Bfsp1),Yeast
  • 货号：
    CSB-EP002680MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Filensin(Bfsp1),Yeast
  • 货号：
    CSB-BP002680MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Filensin(Bfsp1),Yeast
  • 货号：
    CSB-MP002680MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Bfsp1
  • Uniprot No.：
  • 别名：
    Bfsp1; Filensin; Beaded filament structural protein 1; Lens fiber cell beaded-filament structural protein CP 95; CP95) [Cleaved into: Filensin C-terminal fragment; Filensin N-terminal fragment]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-669
  • 氨基酸序列
    MYRRSYVFQA RQERYERAQP AGPAAQPGGT APGLAALQAL GERVAVQVQR ARALQQRHAG LRRQLDAFQR LGEQPGPEDA LARHVEANLQ RARDLTAEHA RLERQEAEAQ RALDEFRSKY ENECECQLVL KEMLERLNKE ADEALLRNLH LQLEAQFLQA DISVAKDRYK KNLLEIQTYI TVLQQIVQTA PQVSLVTGMR ESGLLMQEKL FTEREVAALQ NQLEEGREAV THLQAQKAEL QAQTTALEQA IKHAHECYDE ELQLYNEQIE NLRKEIEEAE RSLERSSYDC RQLAVAQQTL RNELDRYHRI IEIEGSRLSS VFIETPISLI TPSHGAPLSL GSSVKDLARA VQDITAAKPR QKALPKSLPK RKEIIAQDKV EETLEDAPLK PPQEPKALQV ERKAEGGSQP GAGGGHGVSP TQEGGPEDVP DGGQISKAFG KLCKVVKERV SGHKEPEPEP PTDLFTKGRH VLVTGESSFV DPEFYSSSIP ARGGVVISIE EDSMHHDGHV EPSPGQPMPP VENGQGVPQG REGDHSNHQQ GTDKNGLRAK EPKDLEEKDD DGKKEAEGSR RPCPVIIPGP DEPSTSHSQT SGSNQGGPVG PASKSSSLLA KGPSKALSIK KVEVVESIEK ISTESIQTYE ETSVIVETLI GKSKGNKKLG EKSLPDTRA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. Involved in altering the calcium regulation of MIP water permeability.
  • 基因功能参考文献：
    1. CP49 and filensin have been considered robust markers for mouse lens fiber cell differentiation. The data reported here, however, document both proteins in the mouse lens epithelium, but only after 5 weeks of age, when lens epithelial growth and mitotic activity have slowed. PMID: 27559293
    2. AQP0 modulates GJs in the presence of BF proteins to maintain lens transparency and homeostasis. PMID: 29196765
    3. disruption of the Hsf4 gene leads to cataracts via at least three pathways: down-regulation of gamma-crystallin, particularly gamma S-crystallin; decreased lens beaded filament expression; and loss of post-translational modification of alpha A-crystallin PMID: 19224648
  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
  • 蛋白家族：
    Intermediate filament family
  • 组织特异性：
    Detected in eye lens fiber cells (at protein level). Expressed in retinal lens epithelial cells (at protein level).
  • 数据库链接：

    KEGG: mmu:12075

    STRING: 10090.ENSMUSP00000028907

    UniGene: Mm.275937