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  4. Recombinant Mouse Follistatin-related protein 3 (Fstl3)

Recombinant Mouse Follistatin-related protein 3 (Fstl3)

  • 中文名称：
    小鼠Fstl3重组蛋白
  • 货号：
    CSB-YP880629MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Fstl3重组蛋白
  • 货号：
    CSB-EP880629MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Fstl3重组蛋白
  • 货号：
    CSB-EP880629MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Fstl3重组蛋白
  • 货号：
    CSB-BP880629MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Fstl3重组蛋白
  • 货号：
    CSB-MP880629MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fstl3
  • Uniprot No.：
  • 别名：
    Fstl3; Flrg; Follistatin-related protein 3; Follistatin-like protein 3; Follistatin-related gene protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-256
  • 氨基酸序列
    VMGSEDS VPGGVCWLQQ GREATCSLVL KTRVSREECC ASGNINTAWS NFTHPGNKIS LLGFLGLVHC LPCKDSCDGV ECGPGKACRM LGGRPHCECV PNCEGLPAGF QVCGSDGATY RDECELRTAR CRGHPDLRVM YRGRCQKSCA QVVCPRPQSC LVDQTGSAHC VVCRAAPCPV PSNPGQELCG NNNVTYISSC HLRQATCFLG RSIGVRHPGI CTGGPKVPAE EEENFV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiation. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. The nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.
  • 基因功能参考文献：
    1. FSTL3 KO lead to increased activin signaling, enhancing alpha- to beta-cell transdifferentiation in mouse islets. PMID: 26727106
    2. FSTL3 is a critical mediator of exercise-dependent bone formation PMID: 25937185
    3. Data indicate that deletion of activin antagonists follistatin-like-3 (FSTL3) results in hepatic steatosis PMID: 23533219
    4. Suggest FSTL3 has a role in paracrine communication between cardiomyocytes and fibroblasts. PMID: 22915069
    5. crucial roles for FSTL3 in limiting testis organ size and promoting age-related testicular regression PMID: 23407452
    6. These findings link FSTL3 and TGFbeta ligand signaling and a novel subset of the synexpression group of genes to organ/tissue-specific regulatory pathways. PMID: 23022195
    7. These results demonstrate that body composition and glucose homeostasis are differentially regulated by FST and FSTL3 and that their combined loss is associated with increased fat mass and insulin resistance despite elevated insulin production. PMID: 21546932
    8. Fstl3 as a stress-induced regulator of hypertrophy that controls myocyte size via regulation of Smad signaling. PMID: 21245136
    9. genomic organization and promoter analysis PMID: 12039070
    10. regulation and expression patterns of follistatin and FLRG differ; FLRG is distributed in spermatogenic cells of the testis, renal tubules, epithelial cells of the lung, and myocardium PMID: 15451561
    11. review with emphasis on s' works on paracrine and autocrine regulation in activities of Fst and Fstl3, regulation of gonadal development, and structural elements necessary for biological activities PMID: 15451564
    12. Our study indicates that the FLRG protein may contribute to bone formation by inhibiting osteoclast differentiation. PMID: 15574124
    13. FSTL3 regulation of activin and myostatin is critical for normal adult metabolic homeostasis PMID: 17229845
    14. In situ hybridization and immunohistochemical analysis revealed that FLRG is expressed in smooth muscle of the aorta and pulmonary artery, valve leaflets of mitral and tricuspid valves, and cardiac muscles in the ventricle of embryonic heart. PMID: 17878677
    15. expression of follistatin-like 3 can be modulated in adipose tissue and skeletal muscle by chronic obesity PMID: 18334608
    16. Fstl3 is induced in heart by myocardial stress PMID: 19805648

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  • 亚细胞定位：
    Secreted. Nucleus.
  • 组织特异性：
    Abundantly expressed in heart, lung, kidney and testis. Continuously expressed in embryonic heart.
  • 数据库链接：

    KEGG: mmu:83554

    STRING: 10090.ENSMUSP00000020575

    UniGene: Mm.251710