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  4. Recombinant Mouse Forkhead box protein C2 (Foxc2)

Recombinant Mouse Forkhead box protein C2 (Foxc2)

  • 货号：
    CSB-YP733799MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP733799MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP733799MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP733799MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP733799MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Foxc2
  • Uniprot No.：
  • 别名：
    Foxc2; Fkh14; Fkhl14; Mfh1; Forkhead box protein C2; Brain factor 3; BF-3; Forkhead-related protein FKHL14; Mesenchyme fork head protein 1; MFH-1 protein; Transcription factor FKH-14
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-494
  • 氨基酸序列
    MQARYSVSDP NALGVVPYLS EQNYYRAAGS YGGMASPMGV YSGHPEQYGA GMGRSYAPYH HQPAAPKDLV KPPYSYIALI TMAIQNAPEK KITLNGIYQF IMDRFPFYRE NKQGWQNSIR HNLSLNECFV KVPRDDKKPG KGSYWTLDPD SYNMFENGSF LRRRRRFKKK DVPKDKEERA HLKEPPSTTA KGAPTGTPVA DGPKEAEKKV VVKSEAASPA LPVITKVETL SPEGALQASP RSASSTPAGS PDGSLPEHHA AAPNGLPGFS VETIMTLRTS PPGGDLSPAA ARAGLVVPPL ALPYAAAPPA AYTQPCAQGL EAAGSAGYQC SMRAMSLYTG AERPAHVCVP PALDEALSDH PSGPGSPLGA LNLAAGQEGA LGASGHHHQH HGHLHPQAPP PAPQPPPAPQ PATQATSWYL NHGGDLSHLP GHTFATQQQT FPNVREMFNS HRLGLDNSSL GESQVSNASC QLPYRATPSL YRHAAPYSYD CTKY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator. Might be involved in the formation of special mesenchymal tissues.
  • 基因功能参考文献：
    1. Foxc2 influences alveolar epithelial cell differentiation during lung development PMID: 28675425
    2. FOXC1 and FOXC2 are essential regulators of lymphangiogenesis and may have roles in lymphatic-associated diseases PMID: 27214551
    3. Compound, NC-specific Foxc1; Foxc2 homozygous mutant mice have more severe defects in structures of the ocular surface, such as the cornea and eyelids, accompanied by significant declines in the expression of another key developmental factor, Pitx2, and its downstream effector Dkk2, which antagonizes canonical Wnt signaling. PMID: 28253399
    4. Foxc1 and Foxc2 maintain glomerular podocyte integrity by regulating the gene expression. Foxc2 plays a more critical role than Foxc1. PMID: 28223138
    5. Foxc1 and Foxc2 have a role in kidney and axial skeleton development. PMID: 27193493
    6. Our results are consistent with previous reports of Foxc2 expression during early embryogenesis and the Foxc2(CreERT2) mouse provides a tool to investigate spatiotemporal roles of Foxc2 and contributions of Foxc2(+) expressing cells during mouse embryogenesis. PMID: 27783871
    7. Conditional knockout of Foxc2 gene in kidney has been generated using conditional alleles of single-exon gene by double-selection system. PMID: 26542959
    8. Data show that segregation of Foxc2 and NFATc1 transcription factor is closely associated with the highly polarized expression of connexins Cx37, Cx43, and Cx47. PMID: 26953188
    9. deletion of Foxc1 and Foxc2 specifically in Pax3-positive cells affects cell fate choices in the dermomyotome of somites at forelimb level, promoting the myogenic cell fate at the expense of endothelial cells that migrate to the limb PMID: 26839363
    10. Foxc2 in pharyngeal arch mesenchyme is important for aortic arch artery remodelling and ventricular septum formation PMID: 26299482
    11. Foxc2 enhances proliferation of preadipocytes and inhibits apoptosis of preadipocytes by activating the Akt/mTORC1 and ERK/mTORC1 signaling pathways PMID: 26113535
    12. In murine models, inducible deletion of Foxc2 within the lymphatic vasculature led to cell-cell junction defects, regression of valves, and focal vascular lumen collapse, which triggered generalized lymphatic vascular dysfunction and lethality. PMID: 26389677
    13. Foxc2 and Cx37 are elements in a common molecular pathway directing lymphangiogenesis. PMID: 26079578
    14. Foxc2 induces Wnt4 and Bmp4 expression during muscle regeneration and osteogenesis. PMID: 23645207
    15. Results indicate that Foxc2 plays an important role in osteoblastogenesis by promoting osteoblast proliferation, survival and differentiation through up-regulation of integrin beta1 in response to stimuli which induce bone formation. PMID: 21640215
    16. Dysmorphogenesis of lymph nodes in Foxc2 haploinsufficient mice PMID: 21614587
    17. these findings demonstrate that haplodeficiency of Foxc2 results in impaired formation of tumor blood vessels as well as reduced tumor growth and thereby provide evidence that Foxc2 is critical for tumor development and angiogenesis. PMID: 20060810
    18. Foxc2 may have regulatory functions independent of its nuclear transcriptional activity. PMID: 19935708
    19. FoxC2 and Ang2 are novel targets of Prox1 in mouse embryonic-stem-cell-derived endothelial cells. PMID: 19825936
    20. Shows reciprocal inhibition between Pax3 and Foxc2 in the mouse embryo; using both genetic approaches and manipulation of external signals in somite explants, demonstrated that the Pax3:Foxc2 ratio modulates myogenic versus vascular cell fates. PMID: 20059958
    21. insulin and TNF alpha regulate the expression of Foxc2 via a PI3K- and ERK 1/2-dependent pathway in 3T3-L1 adipocytes PMID: 11923482
    22. Mechanisms of FOXC2- and FOXD1-mediated regulation of the RI alpha subunit of cAMP-dependent protein kinase include release of transcriptional repression and activation by protein kinase B alpha and cAMP. PMID: 11943768
    23. FoxC2 blocks adipogenesis by inhibiting the capacity of PPARgamma to promote the expression of a subset of adipogenic genes PMID: 15277530
    24. Foxc2 is expressed in developing lymphatic vessels PMID: 15465483
    25. Results demonstrate that Foxc1 and 2 transcription factors are novel regulators of arterial cell specification upstream of Notch signaling and lymphatic sprouting during embryonic development. PMID: 16678147
    26. Fox2c is required for the development of the second heart field where the outflow tract, right ventricle, and part of the atrium and inflow tract are derived from a second cell lineage encompassing the secondary heart field. PMID: 16839542
    27. Foxc2 plays a key role in metastasis and is associated with aggressive basal-like breast tumors. PMID: 17537911
    28. These results provide novel evidence that Foxc transcription factors are important regulators of the chemotactic motility of endothelial cells through the induction of CXCR4 expression. PMID: 18187037
    29. Foxc2 directly induces Itgb3 expression and regulates angiogenesis by Itgb3-mediated endothelial cell adhesion and migration. PMID: 18579532
    30. the FOXC2-Ang-2 signaling system is crucial for controlling adipose vascular function, which is part of an adaptation to increased adipose tissue metabolism PMID: 18621714
    31. FOXC2 and NFATc1 are potential targets for therapeutic intervention and damage may be a major cause of lymphatic dysfunction. PMID: 19398761
    32. Foxc2 stimulated osteoblast differentiation of mesenchymal cells and preosteoblasts. PMID: 19540201

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: mmu:14234

    STRING: 10090.ENSMUSP00000055290

    UniGene: Mm.14092