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  4. Recombinant Mouse Forkhead box protein D1 (Foxd1)

Recombinant Mouse Forkhead box protein D1 (Foxd1)

  • 货号：
    CSB-YP713970MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP713970MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP713970MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP713970MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP713970MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Foxd1
  • Uniprot No.：
  • 别名：
    Foxd1; Fkhl8; Freac4; Hfhbf2Forkhead box protein D1; Brain factor 2; BF-2; Forkhead-related protein FKHL8; Forkhead-related transcription factor 4; FREAC-4; HFH-BF-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-456
  • 氨基酸序列
    MTLSTEMSDA SGLAEETDID VVGEGEDDEE EEDDDDEGGG GRGGGGSRLP SSAQRRRRSY AGEDDLEDLE EEDDDDLLLA SRPAASPAPP GPAPAPGTGS GGCSGAGAGG GAGGGTGAGT GGGAKNPLVK PPYSYIALIT MAILQSPKKR LTLSEICEFI SSRFPYYREK FPAWQNSIRH NLSLNDCFVK IPREPGNPGK GNYWTLDPES ADMFDNGSFL RRRKRFKRQP LLAPHAAAEA LLLRGAGPAA GAGDPGAALF PPPPPPPACG YGAYGCAYGL QLPPCAPPSA LFAAAAAAAA AAFHPHSPPP PPPPPPPPPG AAAELARTAF GYRSHALAAA LPGPLQAAAV KAGGPGAAAL ARSPFSIESL IGRTRGPAAA GAHVSSGAAS GTAPGPGGGG CAVQAAAGPA VALTRSLVVA AAAAASSVSS SAALGTLHQG TALSSVENFT ARISNC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor involved in regulation of gene expression in a variety of processes including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells. Involved in transcriptional activation of PGF and C3 genes.
  • 基因功能参考文献：
    1. FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation PMID: 30158529
    2. Foxd1 is an upstream positive regulator of renin angiotensin system during early metanephric development and propose that the cross-talk between Foxd1 and RAS is essential in ureter bud-branching morphogenesis. PMID: 28665931
    3. Results showed that FOXD1 is a major actor in mammalian reproduction as sequence variants generated recurrent spontaneous abortion (RSA) and embryonic resorption (ER). PMID: 27805902
    4. mediator and indicator of successful progression of cell reprogramming PMID: 24496101
    5. In this review, we focus on the role of four specific FOX factors (FOXD1, FOXL2, FOXO1 and FOXP3) in gonadotropin hormone production PMID: 24099863
    6. Glomeruli displayed striking abnormalities, in Rbpj knockout mice including a failure of FOXD1-descendent cells to populate the glomerulus PMID: 24226518
    7. In a study to map mice Foxd1-expressing embryonic progenitors cells after bleomycin-induced lung injury, it was found they enter lung buds by 13.5 days post-conception. Collagen-I(alpha)1-expressing mesenchymal cells are also found in adult lung. PMID: 23924232
    8. The studies suggest that Foxd1 is indirectly required for normal Lhb expression and cartilage formation. PMID: 23284914
    9. in the mouse, Foxd1 imprints temporal features in the retina such as axonal ipsilaterality and rostral targeting in collicular areas PMID: 21490208
    10. inducible expression of BF-2, combined with microarray analysis, to identify Placental Growth Factor (PlGF), a Vascular Endothelial Growth Factor (VEGF) family member previously implicated in angiogenesis, as a downstream target of BF-2 PMID: 13678594
    11. even though the ipsilateral program is lost in the retina, a larger than normal uncrossed component develops in Foxd1 deficient embryos PMID: 15509772
    12. Foxd1-null embryo phenotypes are caused by a failure in the correct formation of the renal capsule PMID: 15634693

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Predominantly expressed in the CNS and temporal half of the retina. Also expressed in the condensed head mesenchyme, metanephric blastema of the developing kidney, cortex of the adrenal gland, condensed mesenchyme at the base of the follicles of vibrassae
  • 数据库链接：

    KEGG: mmu:15229

    STRING: 10090.ENSMUSP00000100725

    UniGene: Mm.347441