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  4. Recombinant Mouse Forkhead box protein F1 (Foxf1)

Recombinant Mouse Forkhead box protein F1 (Foxf1)

  • 货号：
    CSB-YP733769MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP733769MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP733769MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP733769MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP733769MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Foxf1
  • Uniprot No.：
  • 别名：
    Foxf1; Fkhl5; Foxf1a; Freac1; Hfh8Forkhead box protein F1; Forkhead-related protein FKHL5; Forkhead-related transcription factor 1; FREAC-1; Hepatocyte nuclear factor 3 forkhead homolog 8; HFH-8
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-378
  • 氨基酸序列
    MSAPDKQQPP HGGGTGGGGG AGGQAMDPAA AGPTKAKKTN AGVRRPEKPP YSYIALIVMA IQSSPSKRLT LSEIYQFLQA RFPFFRGAYQ GWKNSVRHNL SLNECFIKLP KGLGRPGKGH YWTIDPASEF MFEEGSFRRR PRGFRRKCQA LKPVYSMVNG LGFNHLPDTY GFQGSGGLSC APNSLALEGG LGMMNGHLAG NVDGMALPSH SVPHLPSNGG HSYMGGCGGS AAGEYPHHDS SVPASPLLPA GAGGVMEPHA VYSSSAAAWP PAASAALNSG ASYIKQQPLS PCNPAANPLS GSISTHSLEQ PYLHQNSHNG PAELQGIPRY HSQSPSMCDR KEFVFSFNAM ASSSMHTTGG GSYYHQQVTY QDIKPCVM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable transcription activator for a number of lung-specific genes.
  • 基因功能参考文献：
    1. FOXF1 promotes prostate tumor growth and progression by activating ERK5 signaling PMID: 27165781
    2. The Gli increased the activity of one of these long-range enhancers, which was specific to distal blood vessel, suggesting that Shh regulates Foxf1 transcription in pulmonary distal blood vessel formation. PMID: 27166834
    3. Targeted Resequencing of 29 Candidate Genes and Mouse Expression Studies Implicate ZIC3 and FOXF1 in Human VATER/VACTERL Association PMID: 26294094
    4. findings suggest that Foxf1 may serve as a target gene to disrupt progression of liver fibrosis and DBTC might provide a potentially feasible and effective tool for HSC-specific delivery of therapeutic RNA PMID: 25619889
    5. Data indicate FOXF1 transcription factor is required for the formation of embryonic vasculature by regulating endothelial genes critical for vascular development and vascular endothelial growth factor signaling. PMID: 25091710
    6. Endodermal Shh and mesenchymal Foxf1 genes expression were preserved around the hindgut cystic malformation. PMID: 23975021
    7. Foxf1 also directly binds to serum response factor (SRF) and myocardin-related transcription factors (MRTFs). PMID: 23946491
    8. Observations suggest that hedgehog-dependent FoxF1 is a clinically relevant lung CAF-inducing factor, and support experimentally the general concept that CAF properties can be induced by activation of developmentally important transcription factors. PMID: 20233876
    9. Haploinsufficiency of the mouse Forkhead Box f1 gene causes defects in gall bladder development PMID: 11809759
    10. Foxf1 +/- mice exhibited abnormal liver repair, diminished activation of hepatic stellate cells, and increased pericentral hepatic apoptosis following CCl(4) injury. PMID: 12500195
    11. Foxf1 haploinsufficiency disrupted pulmonary expression of genes in the Notch-2-signaling pathway and resulted in abnormal development of lung microvasculature. PMID: 14607778
    12. The developmental expression of forkhead box f1 (Foxf1) in mice is reported. PMID: 16144835
    13. Itgbeta3 is a direct transcriptional target of Foxf1 protein. Foxf1 plays an essential role in mesenchyme migration by transcriptionally regulating Itgbeta3. PMID: 17261592
    14. Sonic hedgehog (Shh) and Fork head box F1 (Foxf1) genes encode regulatory molecules that play a pivotal role in gut and lung morphogenesis. PMID: 17962963
    15. Foxf1 haploinsufficiency caused pulmonary mastocytosis and enhanced pulmonary inflammation after chemically induced or allergen-mediated lung injury, indicating an important role for Foxf1 in the pathogenesis of pulmonary inflammatory responses. PMID: 18421012
    16. study suggests that Foxf1 expression is characteristically up-regulated in tumors with a constitutively activated Hedgehog signaling pathway thereby defining a key role for Foxf1 in Hedgehog-associated tumorigenesis PMID: 19020777
    17. Foxf1a transcript levels decreased during the development of pulmonary hypertension and fibrosis in mice. PMID: 17496152

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed primarily in lung in alveolar type II pneumocyte cells, and to a lesser extent in placenta, stomach, intestine and colon.
  • 数据库链接：

    KEGG: mmu:15227

    STRING: 10090.ENSMUSP00000057481

    UniGene: Mm.33897