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  4. Recombinant Mouse GS homeobox 2 (Gsx2)

Recombinant Mouse GS homeobox 2 (Gsx2)

  • 中文名称：
    小鼠Gsx2重组蛋白
  • 货号：
    CSB-YP009996MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gsx2重组蛋白
  • 货号：
    CSB-EP009996MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gsx2重组蛋白
  • 货号：
    CSB-EP009996MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gsx2重组蛋白
  • 货号：
    CSB-BP009996MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gsx2重组蛋白
  • 货号：
    CSB-MP009996MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gsx2
  • Uniprot No.：
  • 别名：
    Gsx2; Gsh-2; Gsh2; GS homeobox 2; Genetic-screened homeobox 2; Homeobox protein GSH-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-305
  • 氨基酸序列
    MSRSFYVDSL IIKDSSRPAP SLPESHPGPD FFIPLGMPSP LVMSVSGPGC PSRKSGAFCV CPLCVTSHLH SSRPPAGAGG GATGTAGAAV AGGGVAGGTG ALPLLKSQFS PAPGDAQFCP RVSHAHHHHH PPQHHHHHHQ PQQPGSAAAA AAAAAAAAAA AAALGHPQHH APVCAATTYN MSDPRRFHCL SMGGSDTSQV PNGKRMRTAF TSTQLLELER EFSSNMYLSR LRRIEIATYL NLSEKQVKIW FQNRRVKHKK EGKGASRNNH TSCKCVGSQA HYARSEDEDS LSPASANEDK EISPL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that binds 5'-CNAATTAG-3' DNA sequence and regulates the expression of numerous genes including genes important for brain development. During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons.
  • 基因功能参考文献：
    1. Gsx2 is required in septal progenitors for the correct expansion of subventricular zone progenitors specified toward the calretinin(+) subtype PMID: 28814342
    2. we generated a transgenic mouse line driving Cre and EGFP expression with two putative cis-regulatory modules upstream of the homeobox gene Gsx2 , a critical gene for establishing lateral ganglionic eminence (LGE) identity. PMID: 27618396
    3. homeodomain transcription factor Gsx2 plays a crucial role in the region-specific control of adult neural stem cells in both persistent and injury-induced neurogenesis PMID: 23723414
    4. high levels of Gsx2 suppress dendrocyte precursor cells specification in lateral ganglionic eminence progenitors; its downregulation is required for the transition from neurogenesis to oligodendrogenesis PMID: 23637331
    5. Required for retinoid production in the embryonic mouse telencephalon. PMID: 15269172
    6. repression of Ngn1 by Gsh2 promotes the differentiation of dI3 interneurons PMID: 15930101
    7. By analysis of Gsh2 in mutant mice, it can be demonstrated that Gsh2 along with Pax6 are directly required for major aspects of pallial-subpallial boundary progenitor cell specification. PMID: 18701439

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family
  • 数据库链接：

    KEGG: mmu:14843

    STRING: 10090.ENSMUSP00000036625

    UniGene: Mm.218752