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  4. Recombinant Mouse GTP-binding protein REM 2 (Rem2)

Recombinant Mouse GTP-binding protein REM 2 (Rem2)

  • 货号：
    CSB-YP845018MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP845018MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP845018MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP845018MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP845018MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rem2
  • Uniprot No.：
  • 别名：
    Rem2; GTP-binding protein REM 2; Rad and Gem-like GTP-binding protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-341
  • 氨基酸序列
    MHTDLDTDMD MDTETVALCS SSSRQASPLG TPTPEADTTL LKQKPEKLLA ELDLSGPPPA PGVPRRRGSM PVPYKHQLRR AQAVDELDWP PQASPSGSSD SLGSGEAALT QKDGVFKVML VGESGVGKST LAGTFGGLQG DHAHEMENSE DTYERRIMVD KEEVTLIVYD IWEQGDAGGW LQDHCLQTGD AFLIVFSVTD RRGFSKVPET LLRLRAGRPH HDLPVILVGN KSDLARSREV SLEEGRHLAG TLSCKHIETS AALHHNTREL FEGAVRQIRL RRGRGHAGGQ RPEPSSPDGP APPTRRESLT KKAKRFLANL VPRNAKFFKQ RSRSCHDLSV L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.
  • 基因功能参考文献：
    1. Our results highlight Rem2 as a unique molecule that transduces changes in neuronal activity detected at the cell membrane to morphologically relevant changes in gene expression in the nucleus PMID: 29066292
    2. Study have shown that Rem2 is expressed in a variety of nervous system tissues, but is enriched in the basal ganglia. The function of Rem2 in the basal ganglia is unknown, but may be important for neuronal maturation during development, and/or neuroplasticity in adulthood. PMID: 27118437
    3. Nuclear localization of RGK proteins (Rad, Rem, and Rem2) contributes to the suppression of RGK-mediated cell shape remodeling. PMID: 17605760
    4. Voltage dependant calcium channels blockade by Rem2 is likely to be controlled by both the localized concentration of membrane phosphorylated phosphatidylinositide lipids and direct 14-3-3 binding to the Rem2 C-terminus. PMID: 18068949
  • 亚细胞定位：
    Cell membrane.
  • 蛋白家族：
    Small GTPase superfamily, RGK family
  • 数据库链接：

    KEGG: mmu:140743

    STRING: 10090.ENSMUSP00000127199

    UniGene: Mm.274727