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  4. Recombinant Mouse GTPase ERas (Eras)

Recombinant Mouse GTPase ERas (Eras)

  • 货号：
    CSB-YP749250MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP749250MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP749250MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP749250MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP749250MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Eras
  • Uniprot No.：
  • 别名：
    Eras; GTPase ERas; E-Ras; Embryonic stem cell-expressed Ras
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-224
  • 氨基酸序列
    MALPTKSSIL DLSSGTPCTR SPEESHEAWA QCKDAGRQLP EYKAVVVGAS GVGKSALTIQ MTHQCFVKDH DPTIQDSYWK EVARDNGGYI LNVLDTSGQD IHRALRDQCL ASGDGVLGVF ALDDPSSLDQ LQQIWSTWTP HHKQPLVLVG NKCDLVTTAG DAHAAAALLA HKLGAPLVKT SAKTRQGVEE AFALLVHEIQ RAQEAVAESS KKTRHQKAVC SCGC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells.
  • 基因功能参考文献：
    1. ERAS may also play important roles in cell lineage specification during mouse early embryonic development. PMID: 26269429
    2. Collectively, these results unravel the significance of the ERas-Akt-FoxO1 signaling axis in iPSC generation, suggesting a possibly shared molecular basis for both somatic reprogramming and cancer initiation PMID: 23765875
    3. transforming oncogene ERas is important in the tumour-like growth properties of embryonic stem cells PMID: 12774123
    4. ERas and Rheb are two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway; ERas is localized at the plasma membrane, while Rheb is on endomembranes. PMID: 16046393
    5. rasH2 may have a role in susceptibility to chemically-induced tongue and esophageal neoplasms PMID: 18174262
    6. galectin-1 increased DNA synthesis in mouse ES cells via Src, caveolin-1 Akt, and mTOR signaling pathways PMID: 19266163

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 组织特异性：
    Expressed in several undifferentiated mouse embryonic stem cell lines.
  • 数据库链接：

    KEGG: mmu:353283

    STRING: 10090.ENSMUSP00000033500

    UniGene: Mm.250895