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  4. Recombinant Mouse Gamma-aminobutyric acid receptor subunit beta-3 (Gabrb3), partial

Recombinant Mouse Gamma-aminobutyric acid receptor subunit beta-3 (Gabrb3), partial

  • 货号：
    CSB-YP009148MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP009148MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP009148MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP009148MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP009148MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gabrb3
  • Uniprot No.：
  • 别名：
    Gabrb3; Gabrb-3Gamma-aminobutyric acid receptor subunit beta-3; GABA(A) receptor subunit beta-3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA- gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta3/gamma2 receptor exhibits synatogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity. Functions also as histamine receptor and mediates cellular responses to histamine. Plays an important role in somatosensation and in the production of antinociception.
  • 基因功能参考文献：
    1. These results suggest that impairment in GABRB3 downregulates OCA2 and indirectly causes ocular hypopigmentation and visual defects in Angelman syndrome (AS) and Prader-Willi syndrome PMID: 28009282
    2. In Gabrb3 mutant cerebellar nuclei cells, inhibitory postsynaptic current kinetics were unchanged, but mutant males, unlike females, showed enlarged glutamine receptor 1/5 responses and accelerated spontaneous firing. PMID: 27077953
    3. a mouse model demonstrates that alterations in phosphorylation and/or activity of beta3-containing GABAARs may directly contribute to the pathophysiology of autism spectrum disorders PMID: 26627235
    4. The data presented here support the hypothesis that alpha5beta3-GABAARs underlie tonic inhibition in hippocampal CA1 pyramidal cells PMID: 25680234
    5. It was show nthat activation of L-type voltage-gated Ca2+ channels leads to Ca2+/calmodulin-dependent protein kinase II phosphorylation of S383 within the beta3 subunit of the GABAA receptor. PMID: 22531784
    6. GABA A receptor subunit beta3-deficient mice have enhanced risk preference in a probabilistic selection task that requires mice to choose between a small certain reward and a larger uncertain reward. PMID: 22114279
    7. Suggest that forebrain Gabrb3 contributes to hippocampal-dependent memory suppression by isoflurane, but not etomidate. PMID: 21813630
    8. Mice heterozygous for Gabrb3 exhibited an increase in seizure susceptibility and sensitivity to touch and heat. PMID: 20699105
    9. This study demonstrated that beta(3) subunits to slow GABAergic inhibition onto pyramidal neurons and support different roles for these slow inhibitory synapses in the generation and coordination of hippocampal network rhythms. PMID: 19846622
    10. morphologic alterations in the spiral ganglion and Scarpa's ganglion from gamma-aminobutyric acid A (GABA(A)) receptor beta(3) subunit null mutant mice PMID: 12117532
    11. During non-REM sleep, substantial differences in EEG spectral power between genotypes implicate the beta 3 subunit of the GABA-A receptor in regulation of the cortical level expression of sleep states. PMID: 12419540
    12. expression of gene is required for normal palate development PMID: 12606284
    13. Binding to Gaba(A) brain receptors is overall lower in Gabrb3-/- knockout mice than in wild-type, especially in the hippocampus and cerebral cortex where Gabrb3-/- mice have two-thirds the binding of Gabrb3+/+ animals in an Angelman syndrome model. PMID: 12672542
    14. Reduced expression of GABRB3 is associated with autism PMID: 15615769
    15. The maternally-derived male heterozygote may carry a developmental modification resulting in less beta3 protein, which may reflect partial genomic imprinting of the gabrb3 gene in mice. PMID: 15878204
    16. Mice deficient in the gabrb3 gene exhibit a wide assortment of neurochemical, electrophysiological and behavior abnormalities similar to traits observed in autism PMID: 16512358
    17. a gradual increase in GABA-evoked currents in these PRIP deficient neurons correlated with a gradual increase in phosphorylation of GABA(A) receptor beta3 subunit in response to BDNF PMID: 16754670
    18. The gabrb3 gene contributes to LC noradrenergic dendrite development with the disruption of this gene in mice resulting in an enlarged plexus of LC dendrites with a concurrent reduction in muscle tone and marble burying behavior. PMID: 17156762
    19. Modulation of presynaptic Garbrb3 limits the immobilizing actions of GABAergic anesthetics. PMID: 17584992
    20. Conditional inactivation of the beta3 gene revealed novel insight into the function of this GABAA-R subunit in development, behavior, body weight regulation. PMID: 17927825
    21. Gabrb3(-/-) mice displayed significant hypoplasia of the cerebellar vermis, deficits in sociability, social novelty and nesting, and reductions in the frequency and duration of rearing episodes. PMID: 17983671
    22. Our results support the idea that GABAergic anesthetics such as propofol exert their effects, at least in part, by modulating hypothalamic sleep pathways. PMID: 19228970

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  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRB3 sub-subfamily
  • 数据库链接：

    KEGG: mmu:14402

    STRING: 10090.ENSMUSP00000038051

    UniGene: Mm.8004