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  4. Recombinant Mouse General receptor for phosphoinositides 1-associated scaffold protein (Grasp)

Recombinant Mouse General receptor for phosphoinositides 1-associated scaffold protein (Grasp)

  • 中文名称：
    小鼠Grasp重组蛋白
  • 货号：
    CSB-YP888322MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Grasp重组蛋白
  • 货号：
    CSB-EP888322MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Grasp重组蛋白
  • 货号：
    CSB-EP888322MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Grasp重组蛋白
  • 货号：
    CSB-BP888322MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Grasp重组蛋白
  • 货号：
    CSB-MP888322MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Grasp
  • Uniprot No.：
  • 别名：
    Grasp; MNCb-4428General receptor for phosphoinositides 1-associated scaffold protein; GRP1-associated scaffold protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-392
  • 氨基酸序列
    MTLRRLRKLQ QKEEATAAPD PAGRAPDSEA ARAAPLPSGP PAAAAPPGAP GEELYAALED YHPAELYRAL AVSGGTLPRR KGSGFRWKNF TQSPEQQRKV LTLEKGDNQT FGFEIQTYGL HHREEQRVEM VTFVCRVHES SPAQLAGLTP GDTIASVNGL NVEGIRHREI VDIIKASGNV LRLETLYGTS IRKAELEARL QYLKQTLYEK WGEYRSLMVQ EQRLVHGLVV KDPSIYDTLE SVRSCLYGAG LLPGSLPFGP LLAAPGSARG GARRAKGDTD DAVYHTCFFG GAEPQALPPP PPPARALGPS SAETPASVLF PAPRSTLSRS ASVRCAGPGG GGGAPGALWT EAREQALCGA GLRKTKYRSF RRRLLKFIPG LNRSLEEEES QL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses.
  • 基因功能参考文献：
    1. Study results indicate a potential role of Grasp in the p53-mediated response of skin to UVB exposure PMID: 24407555
    2. An upregulation of scaffold protein tamalin is found selectively in the hippocampus of animals subjected to electroconvulsive shock. PMID: 22396401
    3. Caspase cleavage of GRASP-1 occurs in specific brain regions in a time-dependent manner during development and ischemia. PMID: 12207967
    4. tamalin is a novel signaling molecule that possesses a PDZ domain and a PDZ binding motif and mediates Syk signaling in an ITAM-based fashion PMID: 15173175
    5. plays a role in metabotropic glutamate receptor transport and forms its autoinhibitory state.[review] PMID: 18575228

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  • 亚细胞定位：
    Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane.
  • 组织特异性：
    Highly expressed in brain, heart and lung, and to a lower extent in embryo, kidney and ovary.
  • 数据库链接：

    KEGG: mmu:56149

    STRING: 10090.ENSMUSP00000000543

    UniGene: Mm.276573