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  4. Recombinant Mouse Geranylgeranyl pyrophosphate synthase (Ggps1)

Recombinant Mouse Geranylgeranyl pyrophosphate synthase (Ggps1)

  • 中文名称：
    小鼠Ggps1重组蛋白
  • 货号：
    CSB-YP894810MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ggps1重组蛋白
  • 货号：
    CSB-EP894810MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ggps1重组蛋白
  • 货号：
    CSB-EP894810MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ggps1重组蛋白
  • 货号：
    CSB-BP894810MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ggps1重组蛋白
  • 货号：
    CSB-MP894810MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ggps1
  • Uniprot No.：
  • 别名：
    Ggps1Geranylgeranyl pyrophosphate synthase; GGPP synthase; GGPPSase; EC 2.5.1.-,; 2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; EC 2.5.1.1; Farnesyl diphosphate synthase; Farnesyltranstransferase; EC 2.5.1.29; Geranylgeranyl diphosphate synthase; Geranyltranstransferase; EC 2.5.1.10
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-300
  • 氨基酸序列
    MEKTKEKAER ILLEPYRYLL QLPGKQVRSK LSQAFNHWLK VPEDKLQIII EVTEMLHNAS LLIDDIEDSS KLRRGFPVAH SIYGVPSVIN SANYVYFLGL EKVLTLDHPD AVKLFTRQLL ELHQGQGLDI YWRDTYTCPT EEEYKAMVLQ KTGGLFGLAV GLMQLFSDYK EDLKPLLDTL GLFFQIRDDY ANLHSKEYSE NKSFCEDLTE GKFSFPTIHA IWSRPESTQV QNILRQRTEN IDIKKYCVQY LEDVGSFAYT RHTLRELEAK AYKQIEACGG NPSLVALVKH LSKMFTEENK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
  • 基因功能参考文献：
    1. Ggpps deletion enhanced Rheb farnesylation, which subsequently activated mTORC1 and facilitated spermatogonial differentiation PMID: 27374985
    2. the specific deletion of Ggps1, using the Collagen 2-CreER(T2) mice, will accelerate the fracture healing process by activating the Bmp2/Smad-dependent Runx2 pathway. PMID: 28357594
    3. Depletion of GGPP in mouse oocytes impaired the proliferation of granulosa cells, primary-secondary follicle transition and female fertility. GGPP depletion inhibited Rho GTPase geranylgeranylation and its GTPase activity. PMID: 28072828
    4. our data suggest that GGPPS is essential for maintaining fetal lung branching morphogenesis, which is possibly through regulating K-Ras prenylation. PMID: 27106761
    5. GGPPS-controlled protein geranylgeranylation, which regulates formation of the insulin granule docked pool, is critical for beta cell function and insulin release during the development of type 2 diabetes mellitus PMID: 26434932
    6. findings imply that GGPPS deletion induces hepatocyte apoptosis, which makes the liver vulnerable to hepatotoxicity. PMID: 25819439
    7. Data suggest that farnesyltransferase might constitute a target in the management of severe acute pancreatitis (AP). PMID: 24622074
    8. the impact of deleting one copy of FT or GGT on the development of amyloid-beta (Abeta)-associated neuropathology and learning/memory impairments in APPPS1 double transgenic mice. PMID: 24136196
    9. GGPP is critical for the cell-to-cell contact-induced differentiation, in which the down-regulation of GGPPS might be involved. PMID: 16978613

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    FPP/GGPP synthase family
  • 数据库链接：

    KEGG: mmu:14593

    STRING: 10090.ENSMUSP00000126603

    UniGene: Mm.148039