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  4. Recombinant Mouse Glomulin (Glmn)

Recombinant Mouse Glomulin (Glmn)

  • 货号：
    CSB-YP804892MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP804892MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP804892MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP804892MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP804892MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Glmn
  • Uniprot No.：
  • 别名：
    Glmn; Fap48Glomulin; FK506-binding protein-associated protein; FAP; FKBP-associated protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-596
  • 氨基酸序列
    AVEELQSII KRCQILEEHD FKEEDFGLFQ LAGQRCIEDG YINQLLEIIQ DEKNKTIIKS MGWNLVGPVV RCLLRGREED KREECFLIFD LLVKLCNPKE LLLGLLELIE EPSGKQISQI ILLLLQPLQT VIQKLPNNKA YSVGLALSTL WSQLSLLPVP HSEEQIQADD YGLCQCCKAL IEFTKPFVEE VISDKENKEN AKLKDELLKF CFKGLKCPLL TAQFLEQSED VGNDPFRCFA SEIIGFLSKI GHPVPQIILN HGRKKRTWDY LEFEEEEDKQ LAESVASLTY LVFVQGIGID QLPMVLSPSY LLQLNMEHIE VFLQRTEQSI YSKGLELLET SLLRLEDNSL CYQYLEIKSF LAVPQGLVKV MTLCPIETLR KKGLSMLQLF IDKLDSQGKY TLFRCLLNTS NHSGVEAFVI QNIKNQIDLS FKKTYNKWFA GAQLISLLDL VLSLPEGAET DLLQNSDRIM ASLNLLRYLV IKDNEDDNQT GLWTELGKIE NNFLKPLHIG LNMSKAHYEA EIKNSQQNNQ VASMCKGVCS VTVGGEEIPS MPPEMQLKVL HSALFTFDLI ESVLARVEEL IEIKSKSTSE ENVGIK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes. Inhibits E3 ubiquitin ligase activity by binding to the RING domain of RBX1 and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34. Inhibits RBX1-mediated neddylation of CUL1. Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels. Essential for normal development of the vasculature. Contributes to the regulation of RPS6KB1 phosphorylation.
  • 基因功能参考文献：
    1. Results indicate a bacterial adaptation that hijacks inflammasome activation via interactions between IpaH7.8 E3 ubiquitin ligase and glomulin (GLMN). PMID: 25246571
    2. The glomulin expression during murine development (E9.5 days post-coitum until adulthood) by non-radioactive in situ hybridization was studied. PMID: 15053987
  • 组织特异性：
    Ubiquitous. Detected in embryonic vasculature and embryonic perichondrium, and in adult eye, brain, heart, testis, kidney, smooth muscle and skeletal muscle.
  • 数据库链接：

    KEGG: mmu:170823

    STRING: 10090.ENSMUSP00000077168

    UniGene: Mm.41417