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  4. Recombinant Mouse Glucokinase regulatory protein (Gckr)

Recombinant Mouse Glucokinase regulatory protein (Gckr)

  • 中文名称：
    小鼠Gckr重组蛋白
  • 货号：
    CSB-YP852791MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gckr重组蛋白
  • 货号：
    CSB-EP852791MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gckr重组蛋白
  • 货号：
    CSB-EP852791MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gckr重组蛋白
  • 货号：
    CSB-BP852791MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gckr重组蛋白
  • 货号：
    CSB-MP852791MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gckr
  • Uniprot No.：
  • 别名：
    GckrGlucokinase regulatory protein; GKRP; Glucokinase regulator
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-587
  • 氨基酸序列
    MPSTKRYQHV IETPEPGEWE LSGYEAAVPI TEKSNPLTRN LDKADAEKIV QLLGQCDAEI FQEEGQIMPT YQRLYSESVL TTMLQVAGKV QEVLKEPDGG LVVLSGGGTS GRMAFLMSVS FNQLMKGLGQ KPLYTYLIAG GDRSVVASRE RTEDSALHGI EELKKVAAGK KRVVVIGISV GLSAPFVAGQ MDYCMDNTAV FLPVLVGFNP VSMARNDPIE DWRSTFRQVA ERMQKMQEKQ EAFVLNPAIG PEGLSGSSRM KGGSATKILL ETLLLAAHKT VDQGVVSSQR CLLEILRTFE RAHQVTYSQS SKIATLTKQV GISLEKKGHV HLVGWQTLGI IAIMDGVECI HTFGADFRDI RGFLIGDHND MFNQKDELSN QGPQFTFSQD DFLTSVLPSL TEIDTVVFIF TLDDNLAEVQ ALAERVREKS WNIQALVHST VGQSLPAPLK KLFPSLISIT WPLLFFDYEG SYVQKFQREL STKWVLNTRF SGQSKARCIE SLLQVIHFPQ PLSNDVRAAP ISCHVQVAHE KEKVIPTALL SLLLRCSITE AKERLAAASS VCEVVRSALS GPGQKRSIQA FGDPVVP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulates glucokinase (GCK) by forming an inactive complex with this enzyme. Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity.
  • 基因功能参考文献：
    1. This study showed that Sirt2-dependent GKRP deacetylation improves impaired HGU and suggest that it may be a therapeutic target for type 2 diabetes. PMID: 29296001
  • 亚细胞定位：
    Cytoplasm. Nucleus. Mitochondrion.
  • 蛋白家族：
    GCKR family
  • 数据库链接：

    KEGG: mmu:231103

    STRING: 10090.ENSMUSP00000072084

    UniGene: Mm.100043