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  4. Recombinant Mouse Glutathione S-transferase A4 (Gsta4)

Recombinant Mouse Glutathione S-transferase A4 (Gsta4)

  • 中文名称：
    小鼠Gsta4重组蛋白
  • 货号：
    CSB-YP009973MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gsta4重组蛋白
  • 货号：
    CSB-EP009973MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gsta4重组蛋白
  • 货号：
    CSB-EP009973MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gsta4重组蛋白
  • 货号：
    CSB-BP009973MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gsta4重组蛋白
  • 货号：
    CSB-MP009973MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gsta4
  • Uniprot No.：
  • 别名：
    Gsta4; GstaGlutathione S-transferase A4; EC 2.5.1.18; GST A4-4; GSTA4-4; GST class-alpha member 4; Glutathione S-transferase 5.7; GST 5.7
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-222
  • 氨基酸序列
    MAAKPKLYYF NGRGRMESIR WLLAAAGVEF EEEFLETREQ YEKMQKDGHL LFGQVPLVEI DGMMLTQTRA ILSYLAAKYN LYGKDLKERV RIDMYADGTQ DLMMMIAVAP FKTPKEKEES YDLILSRAKT RYFPVFEKIL KDHGEAFLVG NQLSWADIQL LEAILMVEEL SAPVLSDFPL LQAFKTRISN IPTIKKFLQP GSQRKPPPDG PYVEVVRTVL KF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
  • 基因功能参考文献：
    1. Data define a role for GSTA4-4 in buffering hepatic oxidative stress associated with chronic alcohol consumption and that this GST isoform plays an important role in protecting against carbonylation of mitochondrial proteins. PMID: 26654979
    2. although loss of GSTA4-4 led to enhanced susceptibility of cardiac mitochondria to radiation-induced loss of morphology, cardiac function was preserved in Gsta4-null mice PMID: 26010708
    3. These results indicate that 4-HNE significantly contributes to the mechanisms of tubule injury and fibrosis and that these effects can be inhibited by the enhanced expression of GSTA4-4. PMID: 22711583
    4. In the absence of GSTA4-4 to modulate both physiological and pathological 4-hydroxynonenal (HNE) levels, the adaptive NRF-E2-related (Nrf)2 factor pathway may be primed to contribute to a preconditioned cardiac phenotype in the Gsta4-null mouse. PMID: 23690225
    5. The naturally occurring variation in Gsta4 expression in rats affects neurodegeneration after TBI. Further studies are needed to explore if genetic variability in Gsta4 can be associated to outcome also in human TBI. PMID: 22881716
    6. 2-APB treatment restrained nasal lavage fluid LTC4, ECP, ovalbumin-specific IgE, and IL-4 and their corresponding mRNAs in the previously mentioned tissues of treated mice in comparison with those of control ones. PMID: 20832906
    7. Gsta4/GSTA4 is a novel susceptibility gene for NMSC that affects risk in both mice and humans. PMID: 20966433
    8. Results indicate that downregulation of GSTA4 in adipose tissue leads to increased protein carbonylation, ROS production, and mitochondrial dysfunction and may contribute to the development of insulin resistance and type 2 diabetes. PMID: 20150287
    9. mGsta4-null mice, in which 4-HNE detoxification is impaired, have an extended life span. PMID: 19880816
    10. mitochondrial Gsta4 is induced under oxidative stress PMID: 12020353
    11. demonstrated for the first time that protein kinase A and protein kinase C modulate the cytoplasmic and mitochondrial pools GATA4-4 PMID: 12646569
    12. The Gsta4 gene was represented by two EST clones with similar levels of downregulation. PMID: 15629866
    13. mGSTA4 is strongly increased during oxidative stress via JNK activation. PMID: 16223495
    14. Excessive malonyl-CoA synthesized by the more abundant and/or allosterically activated ACC in mGsta4 null mice leads to fat accumulation by the well-known mechanisms of promoting fatty acid synthesis and inhibiting fatty acid beta-oxidation. PMID: 18311940
    15. 4-HNE is involved in p53-mediated signaling in in vitro cell cultures as well as in vivo that can be regulated by glutathione transferase PMID: 18930016
    16. Compensatory induced GSTA4 plays a protective role against oxidative stress in young SOD1 KO mouse kidneys. PMID: 19482077

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    GST superfamily, Alpha family
  • 数据库链接：

    KEGG: mmu:14860

    STRING: 10090.ENSMUSP00000034903

    UniGene: Mm.2662