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  4. Recombinant Mouse Glutathione peroxidase 2 (Gpx2)

Recombinant Mouse Glutathione peroxidase 2 (Gpx2)

  • 中文名称：
    小鼠Gpx2重组蛋白
  • 货号：
    CSB-YP872823MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gpx2重组蛋白
  • 货号：
    CSB-EP872823MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gpx2重组蛋白
  • 货号：
    CSB-EP872823MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gpx2重组蛋白
  • 货号：
    CSB-BP872823MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gpx2重组蛋白
  • 货号：
    CSB-MP872823MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Gpx2Glutathione peroxidase 2; GPx-2; GSHPx-2; EC 1.11.1.9; Glutathione peroxidase-gastrointestinal; GPx-GI; GSHPx-GI
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-190
  • 氨基酸序列
    MAYIAKSFYD LSAIGLDGEK IDFNTFRGRA VLIENVASLU GTTTRDYNQL NELQCRFPRR LVVLGFPCNQ FGHQENCQNE EILNSLKYVR PGGGYQPTFS LTQKCDVNGQ NEHPVFAYLK DKLPYPYDDP FSLMTDPKLI IWSPVRRSDV SWNFEKFLIG PEGEPFRRYS RSFQTINIEP DIKRLLKVAI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. High glutathione peroxidase 2 expression is associated with radiation induced lung disease. PMID: 25150064
    2. we propose that ileocolitis in the GPx1/2-double-knockout mice is caused by Nox1, which is induced by TNF PMID: 24374371
    3. GPx2 is up-regulated in dysplastic colonic crypts, where it appears to act inhibit apoptosis and, thus, supports tumor development. PMID: 23977205
    4. it is concluded that GPx2, although supporting tumor growth, inhibits inflammation-mediated tumorigenesis, but the protective effect of selenium does not strictly depend on GPx2 expression PMID: 22180572
    5. study indicates GI-GPx is spatiotemporally expressed in embryonic organs during organogenesis and may also perform a mutual compensatory role with cGPx in protecting embryos and extraembryonic tissues against reactive oxygen species PMID: 21323725
    6. Loss of Gpx2 is associated with diet induced severe colitis. PMID: 20848490
    7. Genes encoding the antioxidants GPX2 and GSTO 1-1 are common inflammatory genes expressed upon induction of allergic airway inflammation, and independently of allergic susceptibility. PMID: 19897562
    8. A trace amount of Gpx2 is protective against ileocolitis, and selenium and Gpx2 deficient mice will develop pathology similar to normal mice. PMID: 15795427
    9. Glutathione peroxidase 2 (GPX2) is the major oxidative stress-inducible cellular GPX isoform in the lungs, and its basal as well as inducible expression is dependent on Nrf2. PMID: 16794261
    10. GPX2 activity is confined to the mucosal epithelium of the GI tract. Activity is detected all along the crypt-villus axis with concentration in the crypts. GPX1 activity is found in all layers of the gut and all parts of the mucosal epithelium. PMID: 9685647
    11. Mice homozygous for combined targeted mutations of the Gpx1 and Gpx2 genes develop colitis at 11 days of age and ileitis by 21 days of age. This suggests that glutathione peroxidases function to prevent inflammation in the GI tract. PMID: 11518697
    12. In the presence of normal microflora, mice deficient in Gpx1 and Gpx2 by targeted mutation develop ileocolitis at weaning. In the germfree state the mice display no GI tract pathology. PMID: 12751789

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Glutathione peroxidase family
  • 数据库链接：

    KEGG: mmu:14776

    STRING: 10090.ENSMUSP00000081012

    UniGene: Mm.441856