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  4. Recombinant Mouse Glycine receptor subunit beta (Glrb), partial

Recombinant Mouse Glycine receptor subunit beta (Glrb), partial

  • 中文名称：
    小鼠Glrb重组蛋白
  • 货号：
    CSB-YP009520MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Glrb重组蛋白
  • 货号：
    CSB-EP009520MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Glrb重组蛋白
  • 货号：
    CSB-EP009520MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Glrb重组蛋白
  • 货号：
    CSB-BP009520MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Glrb重组蛋白
  • 货号：
    CSB-MP009520MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Glrb
  • Uniprot No.：
  • 别名：
    GlrbGlycine receptor subunit beta; Glycine receptor 58 kDa subunit
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents.
  • 基因功能参考文献：
    1. A species-specific thymine-to-guanine sequence variation in the Glrb gene has been identified which gives rise to species-specific splice donor sites in the Glrb genes of mouse and bushbaby. PMID: 25955356
    2. The SdpI-binding site was mapped to a proline-rich sequence of 22 amino acids within the intracellular loop of GlyRbeta. PMID: 24509844
    3. A retroelement modifies pre-mRNA splicing: the murine Glrb(spa) allele is a splicing signal polymorphism amplified by long interspersed nuclear element insertion. PMID: 22782896
    4. The distinct developmental regulation of GlyRbeta in the murine cochlea advocates a contribution of these chloride channels to efferent olivocochlear innervation. PMID: 21850450
    5. expressed within the germ cells of seminiferous tubules PMID: 12056449
    6. Transcripts are detected in cerebral cortex, liver, and heart. Lack of exon 7 results in a profoundly altered prediction of transmembrane topology. PMID: 17145751
    7. Visual stimulation regulates maturation of retinal ganglion cell synaptic activity and connectivity primarily through glycine receptor-mediated synaptic transmission. PMID: 18425804

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  • 相关疾病：
    Defects in Glrb cause the spastic condition which is characterized by muscle rigidity, tremors, myoclonic jerks, pronounced startle reaction, abnormal gait and impaired righting ability (PubMed:7920630). Neurons from the ventral horn of the spinal cord display reduced inhibitory postsynaptic currents (PubMed:12809985). Likewise, hypoglossal neurons display a dramatic reduction in the frequency and amplitude of postsynaptic inhibitory currents (PubMed:16672662).
  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell junction, synapse. Cell projection, dendrite. Cell membrane; Multi-pass membrane protein. Cytoplasm.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Glycine receptor (TC 1.A.9.3) subfamily, GLRB sub-subfamily
  • 组织特异性：
    Detected in spinal cord, brain and brain stem, especially in the periolivary region, spinal nuclei, trigeminal nucleus, medulla oblongata, pons and midbrain. Detected in the inner plexiform layer of the retina (at protein level). High levels of expression
  • 数据库链接：

    KEGG: mmu:14658

    STRING: 10090.ENSMUSP00000029654

    UniGene: Mm.275639