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  4. Recombinant Mouse Golgi reassembly-stacking protein 2 (Gorasp2)

Recombinant Mouse Golgi reassembly-stacking protein 2 (Gorasp2)

  • 中文名称：
    小鼠Gorasp2重组蛋白
  • 货号：
    CSB-YP858745MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gorasp2重组蛋白
  • 货号：
    CSB-EP858745MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gorasp2重组蛋白
  • 货号：
    CSB-EP858745MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gorasp2重组蛋白
  • 货号：
    CSB-BP858745MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gorasp2重组蛋白
  • 货号：
    CSB-MP858745MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gorasp2
  • Uniprot No.：
  • 别名：
    Gorasp2; Golgi reassembly-stacking protein 2; GRS2; Golgi reassembly-stacking protein of 55 kDa; GRASP55
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-451
  • 氨基酸序列
    GSSQSVEIP GGGTEGYHVL RVQENSPGHR AGLEPFFDFI VSINGSRLNK DNDTLKDLLK ANVEKPVKML IYSSKTLELR EASVTPSNLW GGQGLLGVSI RFCSFDGANE NVWHVLEVES NSPAALAGLR PHSDYIIGAD TVMNESEDLF SLIETHEAKP LKLYVYNTDT DNCREVIITP NSAWGGEGSL GCGIGYGYLH RIPTRPFEEG KKISLPGQMT GTPITPLKDG FTEVQLSSVS PPSLSPPGTT GVEQSLSGLS ISSAPPAVSN VLSTGVPTVP LLPPQVNQSL ASMPPMNPAT TLPSLMPLSA GLPSLPNLPS LSNFNLPAPH IMPGVGLPEL GSPGLPPLPS LPPRNLPGIA PLPMLSDFLP SFPLVPEGSS AASAGEPLSS LPAMGPPSDP VMTTAKADAS SLTVDVTSPA SKVPTTVEDR VSDCTPAVEK PVSDADASEP S
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA. Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells. Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane.
  • 基因功能参考文献：
    1. GOLPH2 promotes the progression of pancreatic ductal adenocarcinoma. PMID: 29344673
    2. Gorasp2-/- mice suffered from spermatogenesis defects. Golgi morphology of spermatocytes was disturbed in Gorasp2-/- mice. GRASP55 interacted via PDZ-mediated interactions with JAMs. PMID: 28617811
    3. GRASP55 responds to inflammasome stimulation,controls autophagy initiation and important for secretion of IL-1b and IL-18 PMID: 22068051
  • 亚细胞定位：
    Golgi apparatus membrane; Lipid-anchor. Endoplasmic reticulum membrane. Golgi apparatus.
  • 蛋白家族：
    GORASP family
  • 组织特异性：
    Detected in lung, heart and testis. Colocalized in a polarized fashion in the acrosome region with JAM3 in round spermatids (at protein level).
  • 数据库链接：

    KEGG: mmu:70231

    STRING: 10090.ENSMUSP00000028509

    UniGene: Mm.271950