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  4. Recombinant Mouse Grainyhead-like protein 1 homolog (Grhl1)

Recombinant Mouse Grainyhead-like protein 1 homolog (Grhl1)

  • 中文名称：
    小鼠Grhl1重组蛋白
  • 货号：
    CSB-YP852842MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Grhl1重组蛋白
  • 货号：
    CSB-EP852842MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Grhl1重组蛋白
  • 货号：
    CSB-EP852842MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Grhl1重组蛋白
  • 货号：
    CSB-BP852842MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Grhl1重组蛋白
  • 货号：
    CSB-MP852842MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Grhl1
  • Uniprot No.：
  • 别名：
    Grhl1; Mgr; Tcfcp2l2; Grainyhead-like protein 1 homolog; Transcription factor CP2-like 2; Transcription factor LBP-32
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-618
  • 氨基酸序列
    MTQEYDNKRP VLVLQNEALY PQRRSYTSED EAWKSFLENP LTAATKAMMS INGDEDSAAA LGLLYDYYKV PRERRSSAVK PEGEHPEPEH SKRNSIPNVT EQPLISAGEN RVQVLKNVPF NIVLPHSNQL GIDKRGHLTA PDTTVTVSIA TMPTHSIKTE IQPHGFAVGI PPAVYHSEPT ERVVVFDRSL STDQFSSGTQ PPNAQRRTPD STFSETFKEG VQEVFFPSEL SLRMPGMNSE DYVFDNVSGN NFEYTLEASK SLRQKQGDST MTYLNKGQFY PVTLKEGSSN EGIHHPISKV RSVIMVVFAE DKSREDQLRH WKYWHSRQHT AKQRCIDIAD YKESFNTISN IEEIAYNAIS FTWDINDEAK VFISVNCLST DFSSQKGVKG LPLNIQIDTY SYNNRSNKPV HRAYCQIKVF CDKGAERKIR DEERKQSKRK VSDVKVQLLP SHKRTDITVF KPFLDLDTQP VLFIPDVHFT NLQRGSHVLS LPSEELEGEG SVLKRGPFGT EDDFGVPPPA KLTRTEEPKR VLLYVRKESE EVFDALMLKT PSLKGLMEAI SDKYDVPHDK IGKIFKKCKK GILVNMDDNI VKHYSNEDTF QLQIEEAGGS YKLTLTEI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3 no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development.
  • 基因功能参考文献：
    1. Significant changes in blood pressure were observed in mice lacking the GRHl1 gene following high and low sodium diet. PMID: 27782736
    2. No involvement of Grhl1 in blood pressure regulation, but Grhl1 expression influences the regulation of heart rate. PMID: 25901299
    3. Loss of Grainy head-like 1 is associated with disruption of the epidermal barrier and squamous cell carcinoma of the skin. PMID: 24586629
    4. Grainyhead like 1 is a transcriptional regulator that may perform important functions in epithelial tissues of mammals and is epidermally expressed PMID: 12666198
    5. Grhl genes are highly expressed in the developing epidermis. PMID: 16831572
    6. Important regulator of the desmoglein 1 genes in the context of hair anchorage and epidermal differentiation. PMID: 18288204

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Grh/CP2 family, Grainyhead subfamily
  • 组织特异性：
    Isoform 1 is highly expressed in brain, pancreas, tonsil, placenta and kidney. Isoform 2 is highly expressed in brain and liver. Expression in the skin is confined to the suprabasal layers of the epidermis and to the hair follicles.
  • 数据库链接：

    KEGG: mmu:195733

    STRING: 10090.ENSMUSP00000082689

    UniGene: Mm.263068