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  4. Recombinant Mouse HORMA domain-containing protein 1 (Hormad1)

Recombinant Mouse HORMA domain-containing protein 1 (Hormad1)

  • 中文名称：
    小鼠Hormad1重组蛋白
  • 货号：
    CSB-YP863520MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hormad1重组蛋白
  • 货号：
    CSB-EP863520MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hormad1重组蛋白
  • 货号：
    CSB-EP863520MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hormad1重组蛋白
  • 货号：
    CSB-BP863520MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hormad1重组蛋白
  • 货号：
    CSB-MP863520MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hormad1
  • Uniprot No.：
  • 别名：
    Hormad1; Nohma; HORMA domain-containing protein 1; Newborn ovary HORMA protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-392
  • 氨基酸序列
    MATMQLQRTA SLSALVFPNK ISTEHQSLMF VKRLLAVSVS CITYLRGIFP ERAYGTRYLD DLCVKILKED KNCPGSSQLV KWMLGCYDAL QKKYLRMIIL AVYTNPGDPQ TISECYQFKF KYTKNGPIMD FISKNQNNKS STTSADTKKA SILLIRKIYV LMQNLGPLPN DVCLTMKLFY YDEVTPPDYQ PPGFKDGDCE GVIFDGDPTY LNVGEVPTPF HTFRLKVTTE KERMENIDST ILKPKESKTQ FEKILMDKDD VEDENHNNFD IKTKMNEQNE NSGASEIKEP NLDCKEEETM QFKKSQSPSI SHCQVEQLVS KTSELDVSES KTRSGKIFQS KMVNGNNQQG QTSKENRKRS LRQFRKTVLH VLESSQESVL KKRRVSEPKE HT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes.
  • 基因功能参考文献：
    1. Exogenous DSBs recruit the meiosis-specific homologous recombination repair machinery, are translocated to the axial elements, contribute to homology recognition, and that their repair is modulated by HORMAD1. PMID: 29414051
    2. that HORMAD1-IHO1 interaction provides a mechanism for the selective promotion of DNA double-strand break formation along unsynapsed chromosome axes PMID: 27723721
    3. These results indicate that Hormad1 deficiency promotes DMC1-independent double-strand break repairs, which in turn helps asynaptic Hormad1(-/-) oocytes resist perinatal loss. PMID: 23759310
    4. By the analysis of Hormad1/Spo11 double mutants, the Hormad1 deficiency was found to abrogate the massive oocyte loss in the Spo11-deficient ovary. The Hormad1 deficiency also causes the eventual loss of pseudo sex body in the Spo11-deficient ovary and testis. PMID: 22530760
    5. propose that the synaptonemal complex and HORMAD1 are key components of a negative feedback loop that coordinates meiotic progression with homologue alignment: HORMAD1 promotes homologue alignment and synaptonemal-complex formation PMID: 21478856
    6. HORMAD1 is a critical component of the synaptonemal complex that affects synapsis, recombination, and meiotic sex chromosome inactivation and transcriptional silencing. PMID: 21079677
    7. HORMAD1 and HORMAD2 are depleted from synapsed chromosome axes with the help of TRIP13. PMID: 19851446
    8. Results suggest that also mammalian cells use a HORMA domain-containing protein (HORMAD1) as part of a surveillance system that monitors chromosomal synapsis or other interactions between homologs. PMID: 19686734
    9. The expression pattern of Nohma suggests that it may be a critical regulatory protein in germ cell meiosis. PMID: 15567723

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  • 亚细胞定位：
    [Isoform 1]: Nucleus. Chromosome.; [Isoform 2]: Cytoplasm.
  • 组织特异性：
    Specifically expressed in meiotic germ cells.
  • 数据库链接：

    KEGG: mmu:67981

    STRING: 10090.ENSMUSP00000088303

    UniGene: Mm.179050