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  4. Recombinant Mouse Haptoglobin (Hp)

Recombinant Mouse Haptoglobin (Hp)

  • 货号：
    CSB-YP010691MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP010691MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP010691MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP010691MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    HpHaptoglobin [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    19-347
  • 氨基酸序列
    VE LGNDAMDFED DSCPKPPEIA NGYVEHLVRY RCRQFYRLRA EGDGVYTLND EKQWVNTVAG EKLPECEAVC GKPKHPVDQV QRIIGGSMDA KGSFPWQAKM ISRHGLTTGA TLISDQWLLT TAKNLFLNHS ETASAKDITP TLTLYVGKNQ LVEIEKVVLH PNHSVVDIGL IKLKQRVLVT ERVMPICLPS KDYIAPGRVG YVSGWGRNAN FRFTDRLKYV MLPVADQDKC VVHYENSTVP EKKNLTSPVG VQPILNEHTF CAGLTKYQED TCYGDAGSAF AIHDMEEDTW YAAGILSFDK SCAVAEYGVY VRATDLKDWV QETMAKN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
  • 基因功能参考文献：
    1. Both immunoblot analyses and enzymelinked immunosorbent assays confirmed the increased concentration of haptoglobin in crude mdx4cv serum. This suggests that haptoglobin, in conjunction with other altered serum proteins, represents a novel diagnostic, prognostic and/or therapymonitoring biomarker candidate to evaluate the inflammatory response in the mdx4cv animal model of dystrophinopathy. PMID: 28440464
    2. Data show that zonulin-dependent small intestinal barrier impairment is an early step leading to the break of tolerance with subsequent development of chronic inflammatory diseases (CIDs). PMID: 28423466
    3. the interaction between haptoglobin genotype and vitamin E affects atherosclerotic plaque progression and stability PMID: 25618031
    4. Suggest haptoglobin is an enhancer of inflammation after cardiac transplantation, contributing to graft rejection. PMID: 25801896
    5. Zonulin facilitates development of acute lung injury (ALI) both by enhancing albumin leak and complement activation as well as increased buildup of neutrophils and cytokines during development of ALI. PMID: 23564505
    6. Haptoglobin deficiency is associated with leakage-prone vessels via isolated VEGFA induction and/or suppressed Ang-1 expression, resulting in unbalanced VEGFalpha/Ang-1 transcription. PMID: 23274064
    7. Hp generated by the B-cell compartment, rather than by the liver, is functionally contributing to a normal immune response. PMID: 23548836
    8. the Hp2-2 protein is involved in aneurysm formation and that the Hp genotype may be a useful biomarker in predicting aneurysm progression PMID: 23096414
    9. Experimental models of colitis showed that haptoglobin has a protective role in inflammatory colitis PMID: 21708824
    10. these studies provide direct evidence that the increased oxidative stress in Hp 2-2 atherosclerotic plaques is due to hemoglobin derived iron. PMID: 19775690
    11. Synthetic PPAR gamma ligands selectively activate PPAR gamma bound to the haptoglobin gene promoter to arrest haptoglobin gene transcription. PMID: 19952271
    12. Hp may be regarded as a regulator of the Th1/Th2 balance in both human and murine immune systems. PMID: 11865978
    13. Hp plays a pivotal role in reducing renal oxidative damage during haemolysis. PMID: 11865980
    14. Haptoglobin gene expression regulation PMID: 11865981
    15. haptoglobin and hemopexin together are essential for protection from splenomegaly and liver fibrosis resulting from intravascular hemolysis PMID: 12393471
    16. the haptoglobin gene expression in adipocytes is stimulated by inflammatory cytokines, glucocorticoids, and the sympathetic system PMID: 14697247
    17. haptoglobin-mediated heme-iron recovery may contribute significantly to iron loading in hemochromatosis PMID: 15613548
    18. a direct linkage between diabetic vascular disease and the Hp genotype. PMID: 15852445
    19. Increased prevalence of diabetic retinopathy in individuals with the haptoglobin 2 genotype. PMID: 16742000
    20. Increased iron, lipid peroxidation and macrophage accumulation in ApoE-/- Hp 2-2 plaques suggests that the haptoglobin genotype plays a critical role in the oxidative and inflammatory response to intraplaque hemorrhage. PMID: 17068284
    21. The reduction in reverse cholesterol transport associated with diabetes mellitus was significantly greater in Hp2-2 mice as compared with Hp1-1 mice PMID: 17082477
    22. results suggest that correct processing of haptoglobin may be sensitive to ER stress & that, in absence of GRP78-mediated assistance, Hp is degraded; data show that iron regulates haptoglobin synthesis & suggest possible link with iron-induced ER stress PMID: 17644369
    23. Suggest that haptoglobin, by controlling plasma levels of hemoglobin, participates in the regulation of ferroportin expression, thus contributing to the regulation of iron transfer from duodenal mucosa to plasma. PMID: 17919498
    24. the Hp 2-2 genotype is critical for the development of severe vasospasm, which typically occurs 24 hours after SAH in mice PMID: 17962599
    25. The phenotype of Hp-deficient mice suggests a major regulatory activity for Hp in supporting proliferation and functional differentiation of B and T cells as part of homeostasis and in response to antigen stimulation. PMID: 18436583
    26. Pharmacogenomic effect of vitamin E on kidney structure and function in transgenic mice with the haptoglobin 2-2 genotype and diabetes mellitus. PMID: 19176700
    27. HDL can become proinflammatory via the hemoglobin x Hp pathway in mice and humans PMID: 19433579
    28. In diabetic mice the Hp 2-2 genotype is associated with increased mortality and more severe cardiac remodeling 30 days after myocardial infarct. PMID: 19490627
    29. Results suggest that HP plays a modulatory and protective role on autoimmune inflammation of the CNS. PMID: 19795414

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase S1 family
  • 组织特异性：
    Expressed by the liver and secreted in plasma.
  • 数据库链接：

    KEGG: mmu:15439

    STRING: 10090.ENSMUSP00000074436

    UniGene: Mm.26730