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  4. Recombinant Mouse Hematological and neurological expressed 1 protein (Hn1)

Recombinant Mouse Hematological and neurological expressed 1 protein (Hn1)

  • 中文名称：
    小鼠JPT1重组蛋白
  • 货号：
    CSB-YP010589MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠JPT1重组蛋白
  • 货号：
    CSB-EP010589MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠JPT1重组蛋白
  • 货号：
    CSB-EP010589MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠JPT1重组蛋白
  • 货号：
    CSB-BP010589MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠JPT1重组蛋白
  • 货号：
    CSB-MP010589MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    JPT1
  • Uniprot No.：
  • 别名：
    Jpt1; Hn1; Jupiter microtubule associated homolog 1; Hematological and neurological expressed 1 protein) [Cleaved into: Jupiter microtubule associated homolog 1; N-terminally processed]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-154
  • 氨基酸序列
    MTTTTTFKGV DPNSRNSSRV LRPPGGGSNF SLGFDEPAEQ PVRKNKMASN IFGTPEENPP SWAKSAGSKS SGGREDSESP GTQRSNSSEA SSGDFLDLKG EGDMHENVDT DFQANLAQME EKPVPAAPVP SPVAPAPVPS RRNPPGGKSS LVLG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation.
  • 基因功能参考文献：
    1. These data suggest a role for Hn1 in the biology of malignant brain tumors. PMID: 19145478
    2. Hn1 mRNA was upregulated in injured facial motoneurons in both rats and mice.These findings identify Hn1 as a gene associated with nervous system development and nerve regeneration. PMID: 16267826
    3. Hn1 depletion in B16.F10 melanoma cells promotes a differentiated phenotype that includes increased melanogenesis and cell cycle arrest. PMID: 19427096
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    JUPITER family
  • 组织特异性：
    Expressed in yolk sac, fetal brain, brain, spleen and bone marrow.
  • 数据库链接：

    KEGG: mmu:15374

    STRING: 10090.ENSMUSP00000021083

    UniGene: Mm.1775