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  4. Recombinant Mouse Hematopoietically-expressed homeobox protein Hhex (Hhex)

Recombinant Mouse Hematopoietically-expressed homeobox protein Hhex (Hhex)

  • 中文名称：
    小鼠Hhex重组蛋白
  • 货号：
    CSB-YP010335MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hhex重组蛋白
  • 货号：
    CSB-EP010335MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hhex重组蛋白
  • 货号：
    CSB-EP010335MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hhex重组蛋白
  • 货号：
    CSB-BP010335MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hhex重组蛋白
  • 货号：
    CSB-MP010335MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hhex
  • Uniprot No.：
  • 别名：
    Hhex; Prh; PrhxHematopoietically-expressed homeobox protein Hhex; Homeobox protein HEX; mHex; Homeobox protein PRH
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-271
  • 氨基酸序列
    MQFPHPGPAA APAVGVPLYA PTPLLQPAHP TPFYIDDILG RGPAAPTPTP TLPSPNSSFT SLVSSYRTPV YEPTPVHPAF SHHPAAALAA AYGPSGFGGP LYPFPRTVND YTHALLRHDP LGKPLLWSPF LQRPLHKRKG GQVRFSNDQT VELEKKFETQ KYLSPPERKR LAKMLQLSER QVKTWFQNRR AKWRRLKQEN PQSNKKDALD SLDTSCEQGQ DLPSEQNKGA SLDRSQCSPS PASQEDPDSE ISEDSDQEVD IEGDKGYFNA G
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. Activator of WNT-mediated transcription in conjunction with CTNNB1. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL. May play a role in hematopoietic differentiation.
  • 基因功能参考文献：
    1. The Hhex evolutionarily conserved non-coding region appears to be a core node for the convergence of the transcription factor network that governs the emergence of Hematopoietic stem cells. PMID: 28189604
    2. Hhex(-/-) mESCs fail to differentiate from definitive endoderm to hepatic endoderm. PMID: 26784346
    3. results implicate Hhex in the maintenance of LT-HSCs and in lineage allocation from multipotent progenitors especially in stress hematopoiesis. PMID: 25968920
    4. Data suggest that Hhex is a novel regulator of c-Myc function that limits c-Myc activity in transformed cells. PMID: 25220416
    5. Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice. PMID: 25283843
    6. Hhex is a key regulator of early lymphoid development, functioning, at least in part, via regulation of the cell cycle. PMID: 25472970
    7. Hhex as the first transcriptional regulator specifically required for islet delta cells and suggest compromised paracrine control as a contributor to T2DM PMID: 24736842
    8. Hex expression and subcellular localization are associated with chondrocyte maturation PMID: 21454303
    9. Loss of Hhex is associated with reduction in hematopoietic maturation accompanied by reduced proliferation. PMID: 20472829
    10. the interaction between Hhex and SOX13 may contribute to control Wnt/TCF1 signaling in the early embryo. PMID: 20028982
    11. identified and characterized a bone morphogenetic protein-responsive element (BRE) within the mouse Hex gene promoter PMID: 12270938
    12. necessary for B cell development and function and its absence results in a dramatic increase in B220(-)CD19(+) cells PMID: 12522149
    13. Hex is a novel regulator of hemangioblast differentiation to hematopoietic and endothelial cells. PMID: 12791650
    14. Hex can act as a T lineage oncogene when misexpressed in hematopoietic precursor cells PMID: 14555989
    15. Controls production of a diffusible heart-inducing factor. PMID: 15687261
    16. Hex functions at multiple stages of development within differentiating embryoid bodies and acts as a negative regulator of the hemangioblast and the endothelial lineage PMID: 15728128
    17. Hex promotes endoderm organogenesis by promoting the transition to a pseudostratified epithelium, which in turn allows hepatoblasts to emerge into the stromal environment and continue differentiating. PMID: 16364283
    18. Hhex-mediated repression of ESM-1 is critical for the normal function of the vascular endothelium and for tumor vasculogenesis. PMID: 16764824
    19. Deletion of Hhex in the hepatic diverticulum (Foxa3-Cre;Hhex(d2,3/-)) led to embryonic lethality and resulted in a small and cystic liver with loss of Hnf4alpha and Hnf6 expression in early hepatoblasts. PMID: 17580084
    20. HEX/Hex is a novel bile acid-induced FXR/Fxr target gene during adaptation of hepatocytes to chronic bile acid exposure. PMID: 19072826

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: mmu:15242

    STRING: 10090.ENSMUSP00000025944

    UniGene: Mm.33896