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Recombinant Mouse Hepatoma-derived growth factor (Hdgf)

  • 中文名称：
    小鼠Hdgf重组蛋白
  • 货号：
    CSB-YP010249MO
  • 规格：
    ￥1836
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP010249MO could indicate that this peptide derived from Yeast-expressed Mus musculus (Mouse) Hdgf.
    • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP010249MO could indicate that this peptide derived from Yeast-expressed Mus musculus (Mouse) Hdgf.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    Hdgf
  • Uniprot No.：
  • 别名：
    Hdgf; Tdrm1; Hepatoma-derived growth factor; HDGF
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length
  • 来源：
    Yeast
  • 分子量：
    30.3kDa
  • 表达区域：
    1-237aa
  • 氨基酸序列
    MSRSNRQKEYKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANKYQVFFFGTHETAFLGPKDLFPYEESKEKFGKPNKRKGFSEGLWEIENNPTVKASGYQSSQKKSCAAEPEVEPEAHEGDGDKKGSAEGSSDEEGKLVIDEPAKEKNEKGTLKRRAGDVLEDSPKRPKESGDHEEEDKEIAALEGERPLPVEVEKNSTPSEPDSGQGPPAEEEEGEEEAAKEEAEAQGVRDHESL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional repressor. Has mitogenic activity for fibroblasts. Heparin-binding protein.
  • 基因功能参考文献：
    1. liver cancer cell-derived HDGF can induce Foxp3(+) T cells; the latter has immune suppressor functions on CD8(+) T cell activities PMID: 25569374
    2. Up-regulation of hepatoma-derived growth factor facilities tumor progression in malignant melanoma. PMID: 23536873
    3. HDGF promotes tumor progression after secondary upregulation and may represent another protein fitting into the concept of non-oncogene addiction of tumor tissue. PMID: 22014102
    4. HDGF exploits the innate properties of both cell surface heparan sulfates and membrane receptor via the HATH domain to affect related cell signalling processes PMID: 20964630
    5. HDGF plays a pro-fibrogenic role during liver fibrosis in mice through activation of TGF-beta pathway. PMID: 19913322
    6. Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus PMID: 11751870
    7. Hepatoma-derived growth factor helps regulate the hepatocyte proliferation in liver development. PMID: 12447878
    8. Increased HDGF expression is correlated with disease progression of hepatocellular carcinoma and represent a specific prognostic factor in patient with liver cancer. PMID: 14508832
    9. we investigated the role of HDGF in tumorigenesis and elucidated the mechanism of action. PMID: 14662017
    10. HDGF is a novel type of neurotrophic factor harbored in the nucleus and it functions in an autocrine manner. PMID: 15140875
    11. hepatoma-derived growth factor has roles in development and intestinal neoplasms PMID: 15604097
    12. HDGF is a novel trophic factor for motor neurons and it might play a protective role against motor neuron degeneration. PMID: 16987236
    13. The lack of obvious biochemical and morphological phenotypes in HDGF-deficient mice demonstrates that in vivo HDGF is dispensable for normal development in mice. PMID: 18570251

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Secreted, extracellular exosome.
  • 蛋白家族：
    HDGF family
  • 组织特异性：
    Expressed predominantly in testis and skeletal muscle, to intermediate extents in heart, brain, lung, liver, and kidney, and to a minimal extent in spleen.
  • 数据库链接：

    KEGG: mmu:15191

    STRING: 10090.ENSMUSP00000005017

    UniGene: Mm.292208