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  4. Recombinant Mouse Heterogeneous nuclear ribonucleoprotein L-like (Hnrpll)

Recombinant Mouse Heterogeneous nuclear ribonucleoprotein L-like (Hnrpll)

  • 货号：
    CSB-YP010630MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP010630MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP010630MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP010630MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP010630MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hnrnpll
  • Uniprot No.：
  • 别名：
    Hnrnpll; HnrpllHeterogeneous nuclear ribonucleoprotein L-like
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-591
  • 氨基酸序列
    MSSSSSSSPK EETYEEDREF ESQAKRLKTE EGEIVYSAEE SENRQEATPQ AGSDSDSGGG DGGDGDGGSG GGGDGEEGEG GEEGDEGDGD EGGSGGDEGG SGGGPRSMPL STEGGGSHHK VSVSPVVHVR GLCESVVEAD LVEALEKFGT ICYVMMMPFK RQALVEFENI DSAKECVTFA ADVPVYIAGQ QAFFNYSTSK RITRPGNTDD PSGGNKVLLL SIQNPLYPIT VDVLYTVCNP VGKVQRIVIF KRNGIQAMVE FESVLCAQKA KAALNGADIY AGCCTLKIEY ARPTRLNVIR NDNDSWDYTK PYLGRRDRGK GRQRQAILGD HPSSFRHDGY GSHGPLLPLP SRYRMGSRDT PELVAYPLPQ ASSSYMHGGS PSGSVVMVSG LHQLKMNCSR VFNLFCLYGN IEKVKFMKTI PGTALVEMGD EYAVERAVTH LNNVKLFGKR LNVCVSKQHS VVPSQIFELE DGTSSYKDFA MSKNNRFTSA GQASKNIIQP PSCVLHYYNV PLCVTEETFT KLCNDHEVLP FIKYKVFDAK ASAKTLSGLL EWKCKTDAVE ALTALNHYQI RVPNGSNPYT LKLCFSTSSH L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.
  • 基因功能参考文献：
    1. HNRNPLL is a novel metastasis suppressor of colorectal cancer, and modulates alternative splicing of CD44 during epithelial-mesenchymal transition. PMID: 28360095
    2. Data suggest that hnRNPLL specifically associates with cytoplasmic PABPC1 in both T-lymphocytes and plasma cells; PABPC1 promotes binding of hnRNPLL to immunoglobulin H (IgH, heavy chain) mRNA and regulates switching from mIgH (membrane isoform) to sIgH (secreted isoform) in plasma cells. (hnRNPLL = heterogeneous nuclear ribonucleoprotein L-like protein; PABPC1 = cytoplasmic poly[A]-binding protein 1) PMID: 28611064
    3. We identify similar patterns of hnRNPLL-induced differential intron retention flanking alternative exons in 14 other genes, representing novel elements of the hnRNPLL-induced splicing program in T cells. PMID: 24476532
    4. Data indicate that the RNA-binding protein hnRNPLL has a critical role in tuning transcriptomes of terminally differentiating B lymphocytes. PMID: 25825742
    5. The splicing factor hnRNPLL and the transcription elongation factor ELL2 modulate the ratio of secred versus membrane-encoding Ighg2b transcripts at the expense of the secreted isoform. PMID: 22991471
    6. results highlight both overlapping and divergent roles for hnRNPLL between conventional T cells and NKT cells PMID: 22073166
    7. In T cells with no CD45 protein, hnRNPLL mutation diminishes peripheral T cell accumulation and demonstrates that hnRNPLL regulates T cell longevity independently from its effects on CD45 splicing. PMID: 20505149
    8. A single substitution in a memory-induced RNA-binding protein, hnRNPLL, destabilized an RNA-recognition domain that bound with micromolar affinity to RNA containing the Ptprc exon-silencing sequence. PMID: 19100700

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  • 数据库链接：

    KEGG: mmu:72692

    STRING: 10090.ENSMUSP00000058308

    UniGene: Mm.64579