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  4. Recombinant Mouse Histamine H1 receptor (Hrh1), partial

Recombinant Mouse Histamine H1 receptor (Hrh1), partial

  • 货号：
    CSB-YP010737MO1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP010737MO1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP010737MO1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP010737MO1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP010737MO1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Hrh1; Bphs; Histamine H1 receptor; H1R; HH1R
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Involved in circadian rhythm of locomotor activity and exploratory behavior. Also involved in responsiveness to pertussis toxin through its control of susceptibility to histamine hypersensitivity and enhancement of antigen-specific delayed-type hypersensitivity responses.
  • 基因功能参考文献：
    1. Data (including data from studies in knockout mice) suggest that sleep-promoting effect of dietary supplement rice bran is dependent on Hrh1 antagonism; rice bran fully inhibits Hrh1 agonist-induced increase in action potential frequency in tuberomammillary nucleus neurons. PMID: 28722302
    2. Study showed that the sleep-wake cycle in H1-/- mice was affected both quantitatively and qualitatively: long-term abolition of histamine impairs cortical EEG, affects sleep-wake qualities and causes sleepiness facing behavioral challenges PMID: 26723880
    3. this study shows that the histamine 1 receptor might be useful therapeutic target for treatment of metal allergy PMID: 27035718
    4. Sympathetic tone changed in H1R-, but not H2R- or H3R-null mice. PMID: 25680462
    5. The results of this study suggest that H1R deficiency in mice is associated with pronounced deficits in hippocampus-dependent spatial learning and memory. PMID: 24862254
    6. These results reveal a crucial role for H1- and H4-receptors for Th2 migration and cytokine secretion in a Th2-driven model of skin inflammation. PMID: 24503582
    7. histamine receptor H1 and histamine receptor H2 reciprocally regulate inflammation in the ligation-induced arteriosclerosis PMID: 24200155
    8. Histamine demonstrably inhibited ACh-induced sweating in both mice and humans via H1R-mediated signaling. PMID: 23900020
    9. Histamine H1 receptors (but not H2) mediate emotional memory consolidation impairment. PMID: 22986235
    10. Histamine H1 receptors in the amygdala are not involved in anxiety-like behavior but are involved in emotional memory. PMID: 22772356
    11. This study provides a potential mechanism of H1R-mediated signaling and NF-kB pathway crosstalk in allergic inflammationptor PMID: 23075496
    12. Neuronal damage is significantly increased in H1R knock-out mice following status epilepticus. PMID: 22348791
    13. Histamine H1 Receptor expression by CD11B(+) cells is not required for susceptibility to experimental allergic encephalomyelitis. PMID: 23121973
    14. An increase in regulatory T cells was observed, yet these cells were incapable of controlling myocarditis in H(1)R(-/-) mice. an increase in regulatory T cells was observed, yet these cells were incapable of controlling myocarditis in H(1)R(-/-) mice. PMID: 22078271
    15. histamine signaling through the H1R on dendritic cells is an important early event conditioning the quality of the skin effector immune response. PMID: 21269673
    16. These data suggest that histamine H1 and H2 receptor signaling may regulate glucose and lipid metabolism and development of hyperlipidemia-induced nonalcoholic steatohepatitis. PMID: 20566747
    17. endothelial H(1)R expression reduces BBB permeability, suggesting that endothelial H(1)R signaling may be important in the maintenance of cerebrovascular integrity PMID: 20956310
    18. The study suggest that H1 receptors play a pivotal role in the regulation of seizure intensity and duration as well as seizure-induced neuronal damage in the immature P9 mice. PMID: 20359868
    19. Regulation of sleep/wake states is completely achieved by OX(2)R-expressing neurones without involving H(1)R-mediated pathways. Maintenance of basal physiological sleep/wake states is fully achieved without both H(1) and OX(1) receptors. PMID: 19694625
    20. H1 receptors have a role in the circadian variation in V(E) through control of acid-base status and metabolism in mice. PMID: 20217356
    21. Histamine H1 receptor activation drives the formation of atherosclerotic lesions through an increased vascular permeability for LDL, which is associated with an enhanced secondary aortic and systemic inflammation. PMID: 20203300
    22. H1R-/- mice were not protected against K/BxN serum-induced arthritis. PMID: 19762454
    23. Histamine H1 receptors play an important role in nasal allergy symptoms induced by histamine in a study comparing histamine H1 receptor-deficient mice with wild-type. PMID: 12095164
    24. congenic mapping links Bphs to the histamine H1 receptor gene(Hrh1); natural alleles of Hrh1 control both the autoimmune T cell and vascular responses regulated by histamine after Bordetella pertussis toxin sensitization PMID: 12142541
    25. Bphs/Hrh1 plays a role in the genetic control of responsiveness to pertussis toxin. PMID: 12595443
    26. histamine H(1)-R signaling pathway may be independent or downstream of the POMC/MC-4R signaling. PMID: 12746338
    27. presence of histamine h1 receptor but not histamine h2 receptor was found in undifferentiated embryonic stem cells PMID: 12755409
    28. Histaminergic mechanisms through H1 receptors play a crucial role not only in amygdaloid kindled seizures but also in the development of amygdaloid kindling. PMID: 15030492
    29. histamine H(1)-Rs are crucial for the regulation of feeding rhythm and in mediating the effects of leptin PMID: 15331534
    30. Histaminergic neurons protect the developing hippocampus from KA-induced neuronal damage, with regulation of neuronal survival being at least partly mediated through H1 receptors. PMID: 16436594
    31. Central histamine contributes via the H1 receptor to changes in metabolic rate during hypoxia to increasehypoxic ventilatory decline in conscious mice. PMID: 16540381
    32. Data establish a role for histamine and histamine type 1 receptors in promoting the migration of Th2 cells into sites of allergen exposure. PMID: 16680192
    33. role of histamine H1 receptors in airway allergic inflammation; findings show that histamine plays an important role via H1 receptors in the development of T helper type 2 responses to enhance airway inflammation PMID: 16685135
    34. Histamine effect was mediated by activation of histamine H1 and H2 receptors that induced inward currents and depolarization. PMID: 16738217
    35. histamine modulates ventilation by affecting metabolism and arousal state via H1 receptors PMID: 16875510
    36. The results of this study demonstrates that both H1 is involved in learning and memory processes for which the frontal cortex, amygdala and hippocampus interact. PMID: 17145090
    37. Histamine H1 receptors are upregulated during bone marrow regeneration in mice. PMID: 17420012
    38. Cytokine-induced endothelial intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expressionwas inhibited by tecastemazole in a manner independent of H1 receptor antagonism. PMID: 17517105
    39. Data suggest that histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal interferon-gamma production in mice. PMID: 17965772
    40. The motivational effects of novelty are diminished in histamine H1-receptor knock- out mice, possibly due to a dysfunctional brain reward system. PMID: 18331338
    41. Results describe the roles of histamine H1 receptors on cognition PMID: 18345498
    42. Initial increases in ventilation were augmented during dark periods. H1 receptors had no major relationship with circadian variation, but affected the declined phase. PMID: 18358081
    43. data are the first to demonstrate that structural polymorphisms influencing cell surface expression of a G protein-coupled receptor in T cells regulates immune functions and autoimmune disease susceptibility PMID: 18490747
    44. ELM and long-term PM are impaired in the homozygous H1R-KO mice. Neurochemical assays revealed that the H1R-KO mice had significantly lower levels of AChE activity in the hippocampus and dopamine turnover in the cerebellum. PMID: 18926883
    45. HR1 immunoreactivity was observed on dopaminergic amacrine cells, calretinin-positive ganglion cells and axon bundles in the ganglion cell layer. PMID: 19015005
    46. Genetic inactivation of the H1 receptor in the mouse leads to spatial working and reference memory impairments, while having no significant effect on emotional behaviour in the light-dark test. PMID: 19413573
    47. Bone marrow-derived mast cell-elaborated histamine inhibits CD4positiveCD25positive regulatory T cell suppressor function by signaling through the histamine H1 receptor. PMID: 19667094

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    KEGG: mmu:15465

    STRING: 10090.ENSMUSP00000086383

    UniGene: Mm.333327