Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse Histone H4 transcription factor (Hinfp)

Recombinant Mouse Histone H4 transcription factor (Hinfp)

  • 货号：
    CSB-YP010361MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP010361MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP010361MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP010361MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP010361MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hinfp
  • Uniprot No.：
  • 别名：
    Hinfp; Mizf; Histone H4 transcription factor; Histone nuclear factor P; HiNF-P; MBD2-interacting zinc finger protein; Methyl-CpG-binding protein 2-interacting zinc finger protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-503
  • 氨基酸序列
    MSPPGKVPRK ENLGLQCEWG SCSFVCSAME EFFDHVTQHL QQHMHGSKEE EEEDPLEEEF SCLWQECGFC SLDSSADLIR HVYFHCYHTK LKQWGLQALQ SQADLSPCIL DFQSRNVIPD TPDHFLCLWE HCESVFDNPE WFYRHVDAHS LCCEYQAVSK DNHVVQCGWK GCTCTFKDRC KLREHLRSHT QEKVVACPTC GGMFANNTKF LDHIRRQTSL DQQRFQCSHC SKRFATERLL RDHMRNHVNH YKCPLCDMTC PLPSSLRNHM RFRHSEDRPY KCDCCDYSCK NLIDLRKHLD THSKESAYRC DFENCNFSAR SLSSVKSHHR KVHEGDSEPR YKCHVCDKCF TRGNNLTVHL RKKHQFKWPS GHPRFRYKEH EDGYMRLQLV RYESVELTQQ LLQQLQEGSD PGLALNESSL QGIVLETVLG GPGPEEETEE EGRVVEGTAL SASQDNPSSA IHMVSQTDTQ GQRDIVYCVL SEGPGEPPPV SETLKRDGKA RGT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.
  • 基因功能参考文献：
    1. Induction of Hinfp begins at the 4-cell stage. Maternally encoded Hinfp sustains development of pre-implantation stage embryos. Hinfp loss delays growth of blastocyst stage embryos that later fail to implant. Hinfp ablation severely reduces histone H4 mRNA and causes DNA damage. Transmission of maternal Hinfp transcripts and zygotic activation of the Hinfp gene together are neeeded to control early H4 gene expression. PMID: 27609454
    2. simultaneous loss of both Hinfp and the p53 checkpoint is detrimental to normal cell growth and may predispose to cellular transformation. PMID: 26030398
    3. Data show that conditional ablation of HINFP compromises cell proliferation, impairs DNA synthesis, alters nucleosome spacing and increases double-stranded DNA damage. PMID: 24797072
    4. The dependence of HiNF-P gene transcription on cyclin E/CDK2/p220NPAT signaling defines a novel feed-forward loop that may sustain HiNF-P expression in proliferating cells to support the cell cycle regulated synthesis of histone H4 proteins. PMID: 17826007
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: mmu:102423

    STRING: 10090.ENSMUSP00000034629

    UniGene: Mm.24570