Recombinant Mouse Histone deacetylase 1 (Hdac1)

1. Hdac1 and Hdac2 as regulators of microglia activation, proliferation, and phagocytosis that define microglia features during the specific conditions of prenatal development and AD-associated neurodegeneration. In contrast, we found that deficiency of Hdac1 and Hdac2 in neuroectodermal cells was not able to modulate amyloid plaque formation. PMID: 29548672
2. HDAC1 depletion caused early beating of cardiomyocytes compared with those of the wild-type (wt) counterpart. PMID: 30115891
3. these data demonstrate the preclinical efficacy of targeting the downstream HDAC1/2-Gli1 acetylation in the treatment of SHH Medulloblastoma. PMID: 28276480
4. p75NTR intracellular domain as a retrograde degenerative signal and reveal p150(Glued) deacetylation as a unique mechanism regulating axonal transport PMID: 30086304
5. the present study demonstrates that lovastatin inhibits the expression of pro-inflammatory mediators, including iNOS and TNF-alpha, through the suppression of HDAC1 expression, PI3K/Akt phosphorylation and NF-kappaB translocation in LPS-stimulated RAW264.7 macrophage cells. PMID: 29207042
6. results show that Hdac1 and Hdac2 function redundantly within the neural crest to regulate proliferation and the development of the pharyngeal arches by means of repression of cyclin-dependent kinase inhibitors. PMID: 28791750
7. the epigenetic regulators HDAC1 and HDAC2 control nephrogenesis via interactions with the transcriptional programs of nephron progenitors and renal vesicles. PMID: 29712641
8. These data suggest that HDAC1-related H3K9ac plays a key role in Hcy-mediated lipid metabolism disorders, and that miR-34a may be a novel therapeutic target in Hcy-related atherosclerosis. PMID: 28485501
9. Early life stress (ELS)-induced schizophrenia-like phenotypes correlate with a widespread increase of Hdac1 expression that is linked to altered DNA methylation. Hdac1 overexpression in neurons of the medial prefrontal cortex, but not in the dorsal or ventral hippocampus, mimics schizophrenia-like phenotypes induced by ELS. PMID: 28533418
10. e results showed mTet1 modified mGSCs had better self-renewal and proliferation ability than wild-type mGSCs, mTet1 could also up-regulate JMJD3 to decrease H3K27me3, which also showed to suppress the MEK-ERK pathway. Furthermore, Co-IP analysis demonstrated that TET1 interact with PCNA and HDAC1 by forming protein complexes to comprehensively regulate dairy goat mGSCs and spermatogenesis. PMID: 27857213
11. reduced HDAC1 levels at promotors of distinct plasticity-associated genes predispose animals exposed to early life stress to enhanced expression of these genes upon cognitive challenge PMID: 27260837
12. HDAC1 SUMOylation functions as an endogenous defense mechanism protecting against Abeta-toxicity. Stimuli such as BDNF, IGF-1 and CRF that increase the level of HDAC1 SUMOylation without altering the HDAC1 expression level PMID: 28186506
13. Mechanical stimulation orchestrates the osteogenic differentiation of human bone marrow stromal cells by regulating HDAC1. PMID: 27171263
14. Co-regulation of H3K9ac by HDAC1 and HDAC3 is important to both embryonic brain development and neuro-differentiation. PMID: 28300292
15. Treatment of the haplotype Npr1(+/-) mice with histone deacetylase inhibitors significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC1/2, NF-kappaB (p65), and STAT1. PMID: 28566502
16. Here, we use transgenic lines to define the in vivo relevance of HDAC1 and identify calcineurin-dependent serine dephosphorylation as the signal modulating the neurotoxic role of HDAC1 in response to neurotoxic stimuli. PMID: 28663197
17. provide new insight into the upstream regulation of Sap90/Psd95-associated protein 3 and establish the essential role of striatal Hdac1, Hdac2 and MeCP2 for suppression of repetitive behaviors PMID: 27668390
18. Taken together, Fam60a is an essential core subunit of a variant Sin3a-Hdac complex in embryonic stem cells that is required to promote rapid proliferation and prevent unscheduled differentiation. PMID: 28554894
19. HDAC1 may be an essential epigenetic regulator of the transition from progenitor cells to terminally differentiated photoreceptors PMID: 28028172
20. Knockdown of HDAC1 recovered Bdnf and Pvalb gene transcription and also prevented the decrease of inhibitory synapses accompanying whisker deprivation PMID: 27534825
21. HDAC1 binds PAX6 and protein-protein interaction leads to transcriptional repression of PAX6 target genes during mouse retinal development PMID: 27871855
22. TGF-beta1-induced inhibition of PPARgamma transcription depends on formation of a functional transcriptional regulatory complex that includes Smad3, mSin3A and HDAC1 at the PPARgamma promoter. PMID: 27941310
23. Data suggest that pathological cardiac hypertrophy involved class I histone deacetylases HDAC1 and HdAC2, tuberous sclerosis complex 2 (TSC2), and mTOR srine-threonine kinases (mTOR). PMID: 27048565
24. Expression of sperm HDAC1 could be considered as a possible predictor of embryo development in mice with high ovarian response. PMID: 25868580
25. Data suggest beta-adrenergic activation of brown adipocytes leads to dissociation of Hdac1 from promoters of Ucp1/Pgc1a, to up-regulation of histone H3 acetylation, to dissociation of polycomb repressive complexes, and to up-regulation of thermogenesis. PMID: 26733201
26. Study shows evidence implicating HDAC1 as an important regulator of tissue damage in rheumatoid arthritis (RA). Its inhibition in RA synovial fibroblasts results in attenuation of the autoaggressive phenotype as reduced proliferation and migration. PMID: 26152200
27. an agomir of miR-874-3p induced osteoblast differentiation and mineralization. These actions were mediated through the inhibition of Hdac1 expression and enhanced Runx2 transcriptional activation. PMID: 26663087
28. HDAC activity down regulates macrophage plasticity favoring the pro-inflammatory phenotype PMID: 26196676
29. Intestinal epithelial cell (IEC) determination and intestinal homeostasis are highly dependent on Hdac1 and Hdac2 activity levels, and changes in the IEC acetylome may alter the mucosal environment. PMID: 26174178
30. HDAC1 deficiency in mESCs partially phenocopies the inhibition of histone deacetylation in vitro, and displays reduced incorporation into neural tissues in vivo. Nodal, which is repressed by histone deacetylation, is a direct target of HDAC1. PMID: 25904100
31. The data of this study demonstrated pronounced and distinctively different changes in the expression of class I HDAC in subfields of the hippocampus after an acute status epilepticus, during epileptogenesis and in chronic TLE. PMID: 26238735
32. results demonstrate that combined HDAC1 and HDAC2 ablation promotes survival of axotomized retinal ganglion cells; HDAC1/2 ablation inhibited the apoptotic pathway by impairing acetylation status of p53 and reducing PUMA expression, thereby contributing to the ensuing enhanced neuroprotection due to HDAC1/2 depletion PMID: 26129908
33. Results showed that the expression levels of HDAC1 and 3 are decreased gradually during embryonic stem cells (ESCs) mesodermal differentiation and interact physically with Bry protein, which is critical for mesodermal lineage commitment. PMID: 25412078
34. Findings demonstrate that honokiol has anti-leukemia activity through inhibiting histone deacetylases (HDACs). PMID: 25187418
35. suppresses glucocorticoid receptor-potentiated preadipocyte differentiation by decreasing CCAAT/enhancer-binding protein alpha and Ppargamma expression levels at the onset of differentiation PMID: 25203139
36. Hdac1 and Hdac2 are crucial for kidney development, regulating Wnt and p53 pathways in the ureteric bud epithelium. PMID: 25758227
37. Report role of myocardial mSin3A/HDAC1/2 complex in mediating the beneficial effects of exercise in diabetic cardiomyopathy. PMID: 23835259
38. cooperation with C/EBP essential for termination of liver regeneration PMID: 25043739
39. The expressions of DNA methlytransferases-1 and histone deacetylases 1 in testes irradiated with 2 Gy were significantly decreased compared with the sham group. PMID: 24027299
40. 5-FU acutely induces the severe myelin degeneration in adolescence and disruption of TCF7L2/HDAC1/HDAC2 complex is at least partially involved in 5-FU-induced demyelination. PMID: 25178657
41. GCN5 and HDAC1 are the crucial enzymes that regulating epigenetic reprogramming; we observed dynamic changes in the expression levels of GCN5 and HDAC1 during embryo development PMID: 23888963
42. In the early stages of cell hypoxia, HDAC-1 binds to HIF-1alpha and results in neprilysin upregulation. PMID: 24947680
43. Excessive HDAC1 activity, is associated with behavioral alterations and dysregulated expression of MHC II and other gene transcripts in the PFC. PMID: 23664640
44. Class I HDAC activity is required for renal protection and regeneration after acute kidney injury. PMID: 24808536
45. HDAC1, HDAC2, and HDAC3 bind at RAREs in the Hoxa1 and Cyp26a1 gene regulatory regions PMID: 24821725
46. data indicate that HDAC1/2 have essential and pleiotropic roles in cellular proliferation and regulate stem cell self-renewal by maintaining expression of key pluripotent transcription factors PMID: 24958871
47. controls differentiation and lineage commitment of CD4 and CD8-positive T-lymphocytes PMID: 24681565
48. Findings suggest that epithelial histone deacetylases HDAC1 and HDAC2 restrain the intestinal inflammatory response, and regulate intestinal epithelial cell proliferation and differentiation. PMID: 24040068
49. by controlling the expression of Pax3 and the concerted action of Pax3 and Sox10 on their target genes, HDAC1/2 direct the specification of neural crest cells into peripheral glia. PMID: 24760871
50. Hdac1 and Hdac2 are essential intestinal epithelial cell homeostasis regulators. PMID: 24525021

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KEGG: mmu:433759

STRING: 10090.ENSMUSP00000099657

UniGene: Mm.202504