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  4. Recombinant Mouse Histone deacetylase 11 (Hdac11)

Recombinant Mouse Histone deacetylase 11 (Hdac11)

  • 货号：
    CSB-YP010237MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP010237MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP010237MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP010237MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP010237MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hdac11
  • Uniprot No.：
  • 别名：
    Hdac11; Histone deacetylase 11; HD11; EC 3.5.1.98
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-347
  • 氨基酸序列
    MPHATQLYQH VPEKRWPIVY SPRYNITFMG LEKLHPFDAG KWGKVINFLK EEKLLSDGML VEAREASEED LLVVHTRRYL NELKWSFVVA TITEIPPVIF LPNFLVQRKV LRPLRTQTGG TIMAGKLAVE RGWAINVGGG FHHCSSDRGG GFCAYADITL AIKFLFERVE GISRATIIDL DAHQGNGHER DFMGDKRVYI MDVYNRHIYP GDRFAKEAIR RKVELEWGTE DEEYLEKVER NVRRSLQEHL PDVVVYNAGT DVLEGDRLGG LSISPAGIVK RDEVVFRVVR AHDIPILMVT SGGYQKRTAR IIADSILNLH DLGLIGPEFP CVSAQNSGIP LLSCAVP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
  • 基因功能参考文献：
    1. HDAC11-suppression suppresses oxidative stress to reduce apoptosis and inflammation in Fructose-treated primary cardiomyocytes. PMID: 29655790
    2. Results demonstrate that HDAC11 is an important metabolic regulator. Mice that lack HDAC11 are protected from diet-induced obesity and fatty liver. PMID: 29958910
    3. our results indicate that HDAC11 would suppress myoblast differentiation via regulation of MyoD-dependent transcription. These findings suggest that HDAC11 is a novel critical target for controlling myoblast differentiation. PMID: 28927261
    4. we have been able to demonstrate a lineage-restricted overexpression of HDAC11 in neutrophils and committed neutrophil precursors and it appears to associate with the transcription machinery, possibly regulating the expression of inflammatory and migratory genes in neutrophils. Our results highlight a unique and novel role for HDAC11 PMID: 28550123
    5. our results indicate that the alcohol-induced responsiveness of Kupffer cells to gut-derived endotoxin, in part, is governed by miR-155 and HDAC11 PMID: 28584078
    6. HDAC11-knockout T cells displayed enhanced proliferation, proinflammatory cytokine production, and effector molecule expression of Eomes and TBX21 transcription factors previously shown to regulate inflammatory cytokine and effector molecule production. PMID: 28550044
    7. HDAC11 appears to function as a negative regulator of myeloid-derived suppressor cells expansion/function in vivo. PMID: 25155994
    8. HDAC6, primarily a cytoplasmic protein, associates with HDAC11 and modulates the expression of IL-10 as a transcriptional activator. PMID: 24747960
    9. The HDAC11 transcript is a PDGF target; the HDAC11 mRNA abundance correlates inversely with proliferative status. PMID: 24047695
    10. Male gender and male hormones accelerate kidney ischemia reperfusion-induced decreases in expression and binding of HDAC11, resulting in an increase in PAI-1 expression. PMID: 23657855
    11. Role for HDAC11 in central nervous system histone deacetylation and the development of oligodendrocytes and neurons during postnatal development. PMID: 17893925
    12. HDAC11 negatively regulated expression of the gene encoding interleukin 10 in antigen-presenting cells. PMID: 19011628

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Histone deacetylase family
  • 数据库链接：

    KEGG: mmu:232232

    STRING: 10090.ENSMUSP00000043828

    UniGene: Mm.206218