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  4. Recombinant Mouse Homeobox protein DBX1 (Dbx1)

Recombinant Mouse Homeobox protein DBX1 (Dbx1)

  • 中文名称：
    Recombinant Mouse Homeobox protein DBX1(Dbx1),Yeast
  • 货号：
    CSB-YP006531MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Homeobox protein DBX1(Dbx1),Yeast
  • 货号：
    CSB-EP006531MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Homeobox protein DBX1(Dbx1),Yeast
  • 货号：
    CSB-EP006531MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Homeobox protein DBX1(Dbx1),Yeast
  • 货号：
    CSB-BP006531MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Homeobox protein DBX1(Dbx1),Yeast
  • 货号：
    CSB-MP006531MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dbx1
  • Uniprot No.：
  • 别名：
    Dbx1; DbxHomeobox protein DBX1; Developing brain homeobox protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-335
  • 氨基酸序列
    MMFPGLLAPP AGYPSLLRPT PTLTLPQSLQ SAFSGHSSFL VEDLIRISRP PTYLSRSIPA ASLSPPSQEA PAALADSGTS DLGSPGSGSR RGSSPQTALS PASEPTFLKF GVNAILSSAP RRETSPALLQ SPPPKTFAFP YFEGSFQPFI RSSYFPASSS VVPIPGTFSW PLAARGKPRR GMLRRAVFSD VQRKALEKTF QKQKYISKPD RKKLASKLGL KDSQVKIWFQ NRRMKWRNSK ERELLSSGGC REQTLPTKLN PHPDLSDVGQ KGPGDEEEDN PGARLAYHAP ADPRHLLEGP LPASPAHSSS PGKPSDFSDS DEDEEGEEDE EITVS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons.
  • 基因功能参考文献：
    1. Here, the s show that the telencephalic preoptic area is comprised of distinct progenitor pools complementarily marked by the transcription factors Dbx1 and Foxp2. As determined by molecular and electrophysiological criteria this embryonic parcellation predicts postnatal medial subnucleus of the amygdala inhibitory neuronal subtype identity. PMID: 28244870
    2. Study defines a fate map of the hypothalamus with respect to Developing Brain Homeobox 1 (Dbx1) expression in hypothalamic progenitor zones. In a temporally regulated manner, Dbx1-derived neurons contribute to molecularly distinct neuronal populations in the hypothalamus that have been implicated in a variety of hypothalamic-driven behaviors PMID: 27209204
    3. En1 and Dbx1 microdomains distinguish midbrain dopamine and hypothalamic neurons PMID: 28174244
    4. preinspiratory Dbx1 neurons are rhythmogenic, inspiratory Dbx1+ and SST+ neurons primarily act to pattern respiratory motor output, and SST+-neuron-mediated pathways and postsynaptic inhibition modulate breathing pattern. I PMID: 27497222
    5. The present data emphasize that synaptic properties of excitatory interneurons of the respiratory rhythmogenic kernel, derived from Dbx1-expressing precursors, may provide the core logic underlying the rhythm for breathing. PMID: 26290237
    6. activity of a single developmentally regulated gene, Dbx1, is a shared requirement for the specification of hypothalamic nuclei governing a subset of innate behaviors. PMID: 25864637
    7. Dbx1 deficiency via laser ablation of neurons in the pre-Botzinger complex stops inspiratory rhythm and impairs output in neonatal mice. PMID: 25027440
    8. These data define Dbx1 as a direct SOX3 target gene. PMID: 24751947
    9. a single transcription factor, Dbx1, has an essential function in assigning midline-crossing identity, thereby contributing crucially to the establishment of the wiring laterality in the developing nervous system PMID: 24553291
    10. dbx1-expressing cells have a unique function during head development, notably by controlling cell survival in a non cell-autonomous manner PMID: 21552538
    11. Loss of septum Dbx1-derived Cajal-Retzius (CR) cells in the rostromedial pallium between E10.5 and E11.5 results in the redistribution of CR subtypes. PMID: 20668538
    12. two spatially distinct and early-specified telencephalic progenitor pools marked by the homeodomain transcription factor Dbx1 are major sources of neuronal cell diversity in the mature mouse amygdala PMID: 19136974

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    H2.0 homeobox family
  • 数据库链接：

    KEGG: mmu:13172

    STRING: 10090.ENSMUSP00000032717

    UniGene: Mm.307176