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  4. Recombinant Mouse Homeobox protein GBX-2 (Gbx2)

Recombinant Mouse Homeobox protein GBX-2 (Gbx2)

  • 中文名称：
    小鼠Gbx2重组蛋白
  • 货号：
    CSB-YP009305MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gbx2重组蛋白
  • 货号：
    CSB-EP009305MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gbx2重组蛋白
  • 货号：
    CSB-EP009305MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gbx2重组蛋白
  • 货号：
    CSB-BP009305MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gbx2重组蛋白
  • 货号：
    CSB-MP009305MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gbx2
  • Uniprot No.：
  • 别名：
    Gbx2; Mmoxa; Stra7; Homeobox protein GBX-2; Gastrulation and brain-specific homeobox protein 2; Stimulated by retinoic acid gene 7 protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-348
  • 氨基酸序列
    MSAAFPPSLM MMQRPLGSST AFSIDSLIGS PPQPSPGHFV YTGYPMFMPY RPVVLPPPPP PPPALPQAAL QPALPPAHPH HQIPSLPTGF CSSLAQGMAL TSTLMATLPG GFSASPQHQE AAAARKFAPQ PLPGGGNFDK AEALQADAED GKAFLAKEGS LLAFSAAEAV QASLVGAVRG QGKDESKVED DPKGKEESFS LESDVDYSSD DNLPGQTAHK EEDPGHALEE TPQSGGAAGS TTSTGKNRRR RTAFTSEQLL ELEKEFHCKK YLSLTERSQI AHALKLSEVQ VKIWFQNRRA KWKRVKAGNA NSKTGEPSRN PKIVVPIPVH VSRFAIRSQH QQLEQARP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May act as a transcription factor for cell pluripotency and differentiation in the embryo.
  • 基因功能参考文献：
    1. Functional studies indicated that Klf4 mediates the self-renewal-promoting effects of Gbx2, because knockdown of Klf4 expression abrogated the ability of Gbx2 to maintain the undifferentiated state of mESCs. PMID: 28848051
    2. Gbx2 is essential for the acquisition of the thalamic neuronal identity by repressing habenular identity through a feedback signaling from postmitotic neurons to progenitors PMID: 26297811
    3. Results reveal a novel function of Gbx2 in mESC reprogramming and LIF/Stat3-mediated self-renewal. PMID: 23345404
    4. Results indicate that the dynamic expression of Gbx2 may act as an important determinant in coupling with other developmental programs to generate distinct thalamic nuclei. PMID: 23056596
    5. Gbx2 regulates thalamocortical axon guidance by modifying the LIM and Robo codes. PMID: 23136391
    6. the Gbx2 homeodomain recognizes the target TAATTA in the FM enhancer, and Gbx2 associates with the FM enhancer in the hindbrain PMID: 22566684
    7. long-term lineage analysis reveals that the presence and timing of Gbx2 expression in interneuron progenitors results in the differential contribution to subtypes of terminally differentiated interneurons in the adult spinal cord PMID: 21698205
    8. gbx2/Gbx2 has an evolutionarily conserved role in anterior hindbrain development. PMID: 21360792
    9. Gbx2 is required for the development of striatal cholinergic interneurons, perhaps by regulating tangential migration of the striatal cholinergic precursors. PMID: 21048141
    10. Data suggest that the juxtaposition of the expression domains of Gbx2 and Otx2 within the mes/r1 area is essential for the maintenance of Fgf8 expression. PMID: 19603509
    11. gbx-2 expression in zebrafish embryo PMID: 11900984
    12. Gbx2 is required after embryonic day 9 (E9) to repress Otx2 in the cerebellar anlage and position the midbrain/hindbrain organizer PMID: 12367504
    13. Sef and Sproutys function synergistically to regulate Gbx2 expression in the anterior hindbrain. PMID: 15729686
    14. Gbx2 is required for development of rhombomeres 1-3, and also for normal gene expression in rhombomeres 4-6. PMID: 15790971
    15. Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling. PMID: 15829521
    16. Loss of Gbx2 results in neural crest cell patterning and pharyngeal arch artery defects in the mouse embryo. PMID: 15996652
    17. Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors PMID: 17060451
    18. differential expression of Gbx2 may be involved in the specific segregation of thalamic neurons, leading to partition of the thalamus into different nuclei PMID: 19279136
    19. Data show that pharyngeal arch artery (PAA) formation requires the pharyngeal surface ectoderm as a signalling centre from which Gbx2, in response to Tbx1, triggers directional cues to the adjacent cardiac neural crest cells en route to the caudal PAAs. PMID: 19700621

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in adult brain, spleen and female genital tract. No expression in heart, liver, lung, kidney, or testis.
  • 数据库链接：

    KEGG: mmu:14472

    STRING: 10090.ENSMUSP00000048508

    UniGene: Mm.204730