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  4. Recombinant Mouse Homeobox protein HMX1 (Hmx1)

Recombinant Mouse Homeobox protein HMX1 (Hmx1)

  • 中文名称：
    小鼠Hmx1重组蛋白
  • 货号：
    CSB-YP010586MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hmx1重组蛋白
  • 货号：
    CSB-EP010586MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hmx1重组蛋白
  • 货号：
    CSB-EP010586MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hmx1重组蛋白
  • 货号：
    CSB-BP010586MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hmx1重组蛋白
  • 货号：
    CSB-MP010586MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hmx1
  • Uniprot No.：
  • 别名：
    Hmx1; H6; Homeobox protein HMX1; Homeobox protein H6
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-332
  • 氨基酸序列
    MPDELTEPGR ATPARASSFL IENLLAAEAK GAGRSTQGDG VREEEEEDDD DPEDEDPEQA RRRLQRRRQQ RAGSGPGGEA RARALGLGPR PPPGPGPPFA LGCGGTTRWY PRVHGGYGGG LSPDTSDRDS PETGEEMGRA ESAWPRCPGP GTVPREVTTQ GPATGGEEAA ELAEAPAVAA AATGEARGGR RKKTRTVFSR SQVFQLESTF DLKRYLSSAE RAGLAASLQL TETQVKIWFQ NRRNKWKRQL AAELEAASLS PPGAQRLVRV PVLYHESPPA AAGPALPFPL APPAPAPPPP LLGFSGALAY PLAAFPAAAS VPFLRAQMPG LV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development of craniofacial structures such as the eye and ear.
  • 基因功能参考文献：
    1. Hoxa2, Meis and Pbx proteins act cooperatively on the ECR, via a core 32 bp sequence, to regulate Hmx1 expression. PMID: 27287804
    2. The Hmx1-miR-204/miR-211 signaling axis contributes to immune suppression in candidemia-induced kidney dysfunction. PMID: 24641951
    3. Gene expression analysis between wild-type and dmbo mice allowed us to develop a predictive promoter model that identified the first target genes of Hmx1. PMID: 23946633
    4. The homeobox transcription factor HMX1 represses Tlx3 and Ret, induces TrkA and maintains tyrosine hydroxylase (Th) expression in precursors, thus driving segregation of the noradrenergic sympathetic fate. PMID: 23591430
    5. Loss of Hmx1 expression results in marked defects in the geniculate (VII) ganglion PMID: 22586713
    6. The mutant Hmx1 alleles represent the first mouse models of a recently-discovered Oculo-Auricular syndrome caused by mutation of the orthologous human gene. PMID: 19379485

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    HMX homeobox family
  • 组织特异性：
    Expressed in neural crest-derived tissues, including, nerve ganglia and cranial mesenchyme.
  • 数据库链接：

    KEGG: mmu:15371

    STRING: 10090.ENSMUSP00000084958

    UniGene: Mm.358606