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  4. Recombinant Mouse Homeobox protein Hox-A10 (Hoxa10)

Recombinant Mouse Homeobox protein Hox-A10 (Hoxa10)

  • 中文名称：
    小鼠Hoxa10重组蛋白
  • 货号：
    CSB-YP010648MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hoxa10重组蛋白
  • 货号：
    CSB-EP010648MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hoxa10重组蛋白
  • 货号：
    CSB-EP010648MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hoxa10重组蛋白
  • 货号：
    CSB-BP010648MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hoxa10重组蛋白
  • 货号：
    CSB-MP010648MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hoxa10
  • Uniprot No.：
  • 别名：
    Hoxa10; Hox-1.8; Hoxa-10Homeobox protein Hox-A10; Homeobox protein Hox-1.8
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-416
  • 氨基酸序列
    MSARKGYLLP SPNYPTTMSC SESPAANSFL VDSLISSGRG EAGVGGGSAG GGGGGYYAHG GVYLPPASDL PYGLQSCGLF PALGSKRNEA PSPGGGGGGG SGGLGPGTHG YAPAPLDLWL DAPRSCRMEP PDGPPPPQPQ PQQQQQQPPP PPPQPPQPQP QATSCSFAQN IKEESSYCLY DAADKCPKGS AAADLAPFPR GPPPDGCALG ASSGVPVPGY FRLSQAYGTA KGFGSGGGGT QQLASPFPAQ PPGRGFDPPP ALASGSTEAA GKERVLDSTP PPTLVCTGGG GSQGDEEAHA SSSAAEELSP APSENSKASP EKDSLGSSKG ENAANWLTAK SGRKKRCPYT KHQTLELEKE FLFNMYLTRE RRLEISRSVH LTDRQVKIWF QNRRMKLKKM NRENRIRELT ANFNFS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.
  • 基因功能参考文献：
    1. Gene-environment interactions driven by early life xenoestrogen exposure likely contributes to increased risk of estrogen-related disease in adults.- PMID: 27312807
    2. Hmgn5 might act downstream of Hoxa10 to regulate the expression of Cox-2, Vegf and Mmp2. PMID: 27579887
    3. Our results suggest that NA10HD increases the number of gamma-globin-transduced HSCs that engraft, leading to an elevated number of fetal hemoglobin-containing red cells. PMID: 28190779
    4. these studies demonstrate a previously undescribed role for HoxA10 in terminating emergency granulopoiesis, suggesting an important contribution by Hox proteins to the innate immune response. PMID: 25895533
    5. Hoxa10 cooperates with Nkx2-5 to regulate the timing of cardiac mesoderm differentiation. PMID: 23477547
    6. results show that reduced APC activity is sufficient to induce formation of epithelial inclusion cysts and support ovarian endometrioid adenocarcinoma development and suggest that induced HOXA10 expression and loss of PTEN are key mechanisms driving endometrioid histotype differentiation and progression PMID: 23276799
    7. Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10. PMID: 22566606
    8. Results suggest that maternal obesity impairs fetal skeletal development through down-regulation of the HoxA10 gene, which may lead to an increase in the prevalence of low bone mass in the offspring later in life. PMID: 22131269
    9. Data show that the extra-embryonic function of Hoxa10, -11, and -13 genes stems from their specific expression in the allantois, an extra-embryonic hallmark of amniote vertebrates. PMID: 22219351
    10. PBX1 plays a central role in attenuating the activity of HOXA10 as an activator of osteoblast-related genes. PMID: 21597276
    11. HoxA10 influences protein ubiquitination by activating transcription of ARIH2, the gene encoding Triad1 PMID: 21454682
    12. Data show that NUP98-HOXA10HD, a novel, canonical NUP98-Hox fusion, significantly enhances the self-renewal capacity of hematopoietic stem cells. PMID: 21130494
    13. extrinsic niche-dependent factors are also involved in the host-dependent outgrowth of leukemias after withdrawal of HOXA10 overexpression event that initiates the leukemia. PMID: 21116281
    14. autocrine stimulation of myeloid progenitors by Tgfbeta2 as one mechanism by which HoxA10 expands this population. PMID: 21087928
    15. HOXA10 differentially regulates endometrial TDO (tryptophan 2,3-dioxygenase) expression in endometrial epithelial and stromal cells. Embryo quality was impaired after treatment with HOXA10 antisense. PMID: 20959529
    16. Chromatin-associated Pbx1 and Hoxa10 were present at osteoblast-related gene promoters preceding gene expression, but only Hoxa10 was associated with these promoters during transcription. PMID: 20439491
    17. Targeted deletion of Hoxa-10 in mice shows severe decidualization defects, primarily due to the reduced stromal cell responsiveness to progesterone. PMID: 19921737
    18. HOXA10 expression leads to production of a less progestin-responsive GABA receptor subtype pi PMID: 20103740
    19. HoxA10 regulates SHP1 and has a role in myeloid differentiation PMID: 12145285
    20. The organization and distribution of lumbar motor neurons was examined in the spinal cords of Hoxa10/Hoxd10 double mutant animals. Double mutant mice have decreased numbers of lumbar motor neurons in both the medial and lateral motor columns. PMID: 12918017
    21. Results suggest that Hoxa10 may activate distinct developmental pathways leading to endometrial differentiation. PMID: 14648870
    22. Msx-1 and Wnt4 signaling during implantation becomes abberant in mice with deleted Hoxa-10. PMID: 14976223
    23. expression of Cyclin G1 and cyclin G2 genes is aberrantly up-regulated in homeo box A-10 mutant uteri, suggesting that cyclin G1 and cyclin G2 genes act as downstream targets of homeobox A-10 and negatively impact uterine cell proliferation PMID: 15661853
    24. Hoxa10-1 directly activated the smooth muscle-specific telokin promoter but did not activate the SM22alpha, smooth muscle alpha-actin, or smooth muscle myosin heavy chain promoters PMID: 15886193
    25. Methoxyhclor disrupts uterine function is by suppressing Hoxa10 expression. PMID: 15890768
    26. cytokine-stimulated pathways regulate HoxA10-mediated repression of the CYBB and NCF2 genes in differentiating myeloid cells and in mature phagocytes during the inflammatory response. PMID: 16210632
    27. Hoxa-10 influences a host of genes and cell functions necessary for propagating normal decidual development during the post-implantation period. PMID: 16337623
    28. The three paralogous genes, Hoxa10, Hoxc10, and Hoxd10, are all expressed in the lumbar spinal cord and have distinct expression patterns. PMID: 16495162
    29. Lif null and Hoxa10 null mice, in which implantation is impaired, have a similar number of endometrial pinopodes compared to fertile ICR mice, therefore pinopodes are not a good indicator of receptivity in mice. PMID: 17313947
    30. HOXA10 subsequently supports bone formation by direct regulation of osteoblast phenotypic genes PMID: 17325044
    31. HoxA10 is a bifunctional protein that is involved in dynamic regulation of multiple aspects of phagocyte phenotype and function PMID: 17439948
    32. Macaca radiata HOXA10 is differentially expressed in endometrial functionalis and basalis zones and is modulated by progesterone and preimplantation embryo. In presence of embryo, it is decreased in luminal epithelium but increased in stroma and glands. PMID: 17709569

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Abd-B homeobox family
  • 组织特异性：
    Expressed in the developing limb bud where it is restricted to the mesenchyme along the proximal-distal axis. Also found in developing gut and urogenital tract. In adult tissue, both forms found in kidney but only isoform 1 is expressed in skeletal muscle
  • 数据库链接：

    KEGG: mmu:15395

    STRING: 10090.ENSMUSP00000120276

    UniGene: Mm.5