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  4. Recombinant Mouse Homeobox protein Hox-B13 (Hoxb13)

Recombinant Mouse Homeobox protein Hox-B13 (Hoxb13)

  • 中文名称：
    小鼠Hoxb13重组蛋白
  • 货号：
    CSB-YP010661MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hoxb13重组蛋白
  • 货号：
    CSB-EP010661MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hoxb13重组蛋白
  • 货号：
    CSB-EP010661MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hoxb13重组蛋白
  • 货号：
    CSB-BP010661MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hoxb13重组蛋白
  • 货号：
    CSB-MP010661MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hoxb13
  • Uniprot No.：
  • 别名：
    Hoxb13; Homeobox protein Hox-B13
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-286
  • 氨基酸序列
    MEPGNYATLD GAKDIEGLLG AGGGRNLVSH SSPLASHPAA PTLMPTVNYA PLDLPGSAEP PKQCHPCPGV PQGASPAPVP YGYFGGGYYS CRVSRSSLKP CAQTAALATY PSETPAPGEE YPSRPTEFAF YPGYPGPYQP MASYLDVSVV QTLGAPGEPR HDSLLPVDSY QPWALAGGWN SQMCCQGEQN PPGPFWKAAF AEPSVQHPPP DGCAFRRGRK KRIPYSKGQL RELEREYAAN KFITKDKRRK ISAATSLSER QITIWFQNRR VKEKKVLAKV KTSTTP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA.
  • 基因功能参考文献：
    1. Cdx and Wnt mutations and premature Hox13 expression also cause similar neural dysmorphology PMID: 21752936
    2. Hoxb13 has a negative effect on skin wound repair PMID: 19759546
    3. results suggest a specific role for Hoxb13 in a differentiation pathway that gives the ventral prostate epithelium a unique identity, as well as a more general role in ventral prostate morphogenesis that is redundant with other Hox13 paralogs PMID: 12668621
    4. Hoxb13 knockout mice exhibit enhanced cutaneous wound healing. PMID: 12759339
    5. Epidermal HOXB13 signal was detected over the entire body surface, but surprisingly, essentially all of the signal was cytoplasmic in developing skin PMID: 12761847
    6. An increase of the Ala repeat above a certain length (22 Ala)in the Hoxd13 sequence, resulting in synpolydactyly, is associated with a shift in the localization of Hox13 from nuclear to cytoplasmic and aggregation. PMID: 15333588
    7. Hoxb13 cis-regulatory elements provide a powerful tool to achieve androgen-independent transgene expression in the prostate and distal colon-specific expression in the gastrointestinal tract PMID: 19191217

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Abd-B homeobox family
  • 组织特异性：
    Exhibits both spatial and temporal colinearity within the main body axis. At E12.5, is detected in hindgut, urogenital tract, spinal chord and tailbud. Not detected in secondary axes such as the limb and the genital tubercule.
  • 数据库链接：

    KEGG: mmu:15408

    STRING: 10090.ENSMUSP00000056315

    UniGene: Mm.57221